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Belgian drugmaker Argenx said Tuesday that its antibody medicine failed to achieve the goals of a late-stage study for a platelet-destroying autoimmune disorder — a setback in the company’s efforts to expand the drug’s use.

Argenx shares were down 12% in early trading.

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The negative study, called ADVANCE-SC, was the second of two clinical trials involving the Argenx drug, called efgartigimod, in patients with primary immune thrombocytopenia (ITP), a debilitating condition that destroys blood-clotting platelets. When severe and uncontrolled, ITP can force patients to have their spleen removed.

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