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In an era when huge price hikes for prescription drugs are almost guaranteed to draw criticism, is there any circumstance when a 486% increase for a medicine might appear to be justified? STAT asks. A small company called Harrow argues that it can make the case for an injectable eye treatment that has been used to combat several serious conditions. Company executives maintain the medication, which has been largely out of stock for the past few years, requires substantial investment in order to restore a steady supply and, moreover, was substantially underpriced. But some industry experts say a successful relaunch will largely depend on reactions among eye specialists.

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Novartis plans to cut up to 680 jobs in its product development organization, Reuters notes. Around 440 jobs will go in Switzerland and up to 240 in the U.S. over the next two to three years. The job eliminations are separate from a restructuring program that could lead to 8,000 of its 78,000 global workforce being cut. Novartis currently employs around 12,500 in development, which includes handling drug regulations, analytics, and support functions like quality assurance. Meanwhile, the company said it would add roles over the next two to three years, meaning there will be a net reduction overall of 1%-2% at a global level.

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