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Asahi Kasei Pharma starts Phase III study of CIPN prevention therapy

Express Pharma

Asahi Kasei Pharma has started trial drug administration in a Phase III study of ART-123 in Japan (generic name: thrombomodulin alfa; marketed as Recomodulin Injection in Japan) for the prevention of chemotherapy-induced peripheral neuropathy (CIPN) related symptoms.

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Prevalence of Dosage Modifications and Impact on Response Milestone Among Patients With CML Treated With Imatinib Using RWD

Pharmacy Times

Eligible patients include adults (≥ 18 years) diagnosed with CML receiving imatinib as first-line therapy for more than 1 month between 2008 and 2023. Materials and Methods This retrospective observational study utilized the Carolina Data Warehouse for Health electronic health record (EHR) database.

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Cold Sore

RX Note

Patients on chemotherapy, oral corticosteroids or drugs for HIV May be susceptible to more severe infection. Cold sores located in the mouth or close to the eye Outside scope of community pharmacy. Lesions that spread away from the lips and onto the face Impetigo more likely.

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Treatment shows strong potential for ALK-driven neuroblastoma

European Pharmaceutical Review

In the Phase I New Approaches to Neuroblastoma Therapy (NANT) trial, researchers found that lorlatinib given alone or in combination with chemotherapy was safe and tolerable in patients with relapsed/refractory anaplastic lymphoma kinase (ALK)-driven neuroblastoma. In 2008, the ALK gene was found to hold a key role in the disease.

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Targeting ovarian cancer with a novel antibody therapeutic

European Pharmaceutical Review

This authorisation of the antibody drug conjugate Elahere provides a much needed clinically meaningful option for women living with this type of ovarian cancer, whose disease returns because they develop resistance to platinum-based chemotherapy regimens. 2008; 28(6A):35673572. Int J Gynecol Cancer. 2022; 32(6). Anticancer Res.

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Country focus: China & APAC’s growing medical needs bring opportunities and challenges

pharmaphorum

Chemotherapy still accounted for 72.6% Chemotherapy still plays a significant role in oncology treatment, accounting for 72.6% While all of the top ten best-selling oncology drugs in the US in 2019 were innovative therapies, four out of the top ten best-selling oncology drugs in China were for conventional chemotherapy. “In

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Takeda farms out cancer drug alisertib to Puma Biotech

pharmaphorum

billion buyout of Millennium Pharma way back in 2008 – but those were dashed in 2015 when the drug failed to move the needle in a trial involving patients with peripheral T-cell lymphoma (PTCL). Takeda is also in line for just over $287 million in potential milestone payments, plus royalties on net sales if it reaches the market.