Wed.Apr 24, 2024

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Opinion: Balancing hope and reality: The promise and peril of blood-based colorectal cancer screening

STAT

As a gastroenterologist and cancer researcher, my mission is to help my patients live longer, healthier, and cancer-free lives. A rise in the number of younger Americans diagnosed with colorectal cancer worries me — early-age onset colorectal cancer is expected to surge by more than 140% by 2030. But because colorectal cancer is preventable with early screening and detection, it’s possible to reduce the number of Americans diagnosed with this disease in the prime of their lives.

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AbbVie and Regenxbio’s ‘multibillion-dollar opportunity’ in vision loss gene therapy

PharmaVoice

After a successful mid-stage study, the companies aim to upend traditional wet AMD treatments with a one-time gene therapy.

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Massive amounts of H5N1 vaccine would be needed if there’s a bird flu pandemic. Can we make enough?

STAT

The unsettling reality of H5N1 bird flu circulating in dairy cow herds in multiple parts of the United States is raising anxiety levels about whether this dangerous virus, which has haunted the sleep of people who worry about influenza pandemics for more than 20 years, could be on a path to acquiring the ability to easily infect people. To be clear, there is no evidence that this is currently the case — the sole confirmed human case reported in Texas three weeks ago was in a farm worker w

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NICE backs Novartis duo for NHS use in young glioma patients

pharmaphorum

An oral therapy that can allow children and adolescents with an aggressive form of brain cancer to be treated at home rather than in hospital has been recommended for use by the NHS in England and Wales.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Chocolate milk will stay on school lunch menus, as USDA reverses course

STAT

WASHINGTON – Chocolate milk in schools is here to stay. The Department of Agriculture announced Wednesday that it has abandoned a previous proposal to restrict the sale of flavored milk in elementary and middle schools. Instead, the USDA will enforce a limit on added sugars in flavored milk starting in the fall of 2025.

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Roche says it has shed 20% of NMEs from its pipeline

pharmaphorum

Roche chief executive Thomas Schinecker said today that one in five of the pharma division’s pipeline of new molecular entities (NMEs) has been culled in the last few months as part of a shift in focus on “high impact” projects.

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Enter Xaira, with $1bn for its AI in drug discovery platform

pharmaphorum

New biotech Xaira Therapeutics emerges with $1bn in funding for its plan to apply AI to drug discovery in ways hard to achieve with conventional technologies

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STAT+: Biosimilars haven’t always yielded lower out-of-pocket costs for patients, study finds

STAT

Two years after biosimilars became available in the U.S., a higher proportion of patients using brand-name biologics were paying out-of-pocket costs, which were also, on average, 12% higher than before, according to a recent study. In addition, patients who used biosimilars often did not pay lower out-of-pocket costs than those who were given brand-name biologic medicines.

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GSK’s Jemperli accepted for FDA review for endometrial cancer treatment

Pharmafile

GSK has announced that the US Food and Drug Administration (FDA) has accepted its supplemental Biologics License Application (sBLA) for Jemperli (dostarlimab) in combination with standard-of-care chemotherapy (carboplatin and paclitaxel) to expand its use to the treatment of adult patients with primary advanced or recurrent endometrial cancer. This will now include patients with mismatch repair proficient (MMRp)/microsatellite stable (MSS) tumours.

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STAT+: HCA to expand the use of AI tool to automate clinical documentation in ER

STAT

HCA Healthcare, the largest for-profit hospital chain in the United States, is planning to expand the use of an artificial intelligence tool to document doctor-patient interactions in its emergency rooms. The plans for a broader roll out of the AI tool across its network comes nearly a year after the 184-hospital health system started working with medical documentation company Augmedix to pilot its ambient scribe technology at a handful of ER departments within the HCA network.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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CureVac to cut costs in restructuring

BioPharma Dive

The mRNA vaccine maker, which has lost most of its value since early 2021, is undergoing an “organizational redesign” that will involve the elimination of 150 positions.

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Watch: What we know about traces of H5N1 bird flu found in pasteurized milk

STAT

Genetic evidence of the H5N1 bird flu virus was  found in grocery store milk in the United States this week, according to the Food and Drug Administration. The news follows the discovery that the avian flu has been detected in dairy cows. But what do traces of virus in pasteurized milk mean for consumers? In this video, STAT explains what is known about the safety of milk on grocery shelves.

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RPS expands patient safety standards to all settings

The Pharmacist

The Royal Pharmaceutical Society (RPS) has published updated patient safety standards to reflect legislative, regulatory, and national developments since the standards’ previous iteration in 2016. The updated standards also seek to include ‘all roles and sectors within pharmacy’, beyond the predominantly community-pharmacy-focused scope of the previous standards, as well as providing consistency across the United […] The post RPS expands patient safety standards to all settings appeared fi

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STAT+: Biogen’s Alzheimer’s drug launch on ‘steady pace’ as logistical hurdles recede

STAT

Biogen on Wednesday reported first-quarter earnings that beat Wall Street expectations largely on reduced expenses. Total revenue was slightly weak overall, but sales were stronger for two newly launched medicines — Leqembi and Skyclarys — that matter most to the biotech’s turnaround effort. Shares rose 5% to $202 in early trading.

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FDA initiative puts AR/VR at heart of home health drive

pharmaphorum

A new FDA initiative is seeing how augmented reality and virtual reality (AR/VR) can make patients’ own homes an integral part of the healthcare system

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Decline in heart failure deaths has been undone, led by people under 45

STAT

Heart failure mortality rates are moving in the wrong direction, a new analysis reports, reversing a decline in deaths that means more people in the United States are dying of the condition today than 25 years ago. The concerning conclusion comes as newer medications are raising hopes for better outcomes in the years to come. A research letter published Wednesday in JAMA Cardiology tracked U.S. death certificate data from 1999 through 2021, revealing a steady drop in deaths until 2012, when rate

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Endeavor pulls in $132M to back cancer, lung disease drugs

BioPharma Dive

Led by the founder of a biotech Celgene acquired for $7 billion, the startup is developing two prospects that originated in the labs of other drugmakers.

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STAT+: A spending frenzy on obesity drugs

STAT

Want to stay on top of the science and politics driving biotech today?  Sign up  to get our biotech newsletter in your inbox. Good morning! Today we have some developments about Novo Nordisk’s insulin business, a side of the company that people don’t really talk about anymore, and some news about their GLP-1 business, a side that people can’t stop talking about.

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NICE recommends Novartis precision brain cancer treatment

European Pharmaceutical Review

in clinical trials [the combination treatment was shown] to halt tumour growth for low-grade gliomas for an average of more than two years” The National Institute for Health and Care Excellence (NICE) has recommended a new targeted drug combination treatment for young people with BRAF V600E mutation-positive glioma. Dabrafenib (Finlee) in combination with trametinib (Spexotras) is indicated for patients aged one and over, based on the agency’s proposal in its final draft guidance.

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She was too sick for a traditional transplant. So she received a pig kidney and a heart pump

STAT

NEW YORK — Doctors have transplanted a pig kidney into a New Jersey woman who was near death, part of a dramatic pair of surgeries that also stabilized her failing heart. Lisa Pisano’s combination of heart and kidney failure left her too sick to qualify for a traditional transplant, and out of options. Then doctors at NYU Langone Health devised a novel one-two punch: Implant a mechanical pump to keep her heart beating and days later transplant a kidney from a genetically modified p

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UCL study to assess link between navigation and AD using virtual reality

Pharma Times

The progressive neurodegenerative condition is the most common form of dementia

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Eli Lilly acquires new manufacturing facility from Nexus Pharmaceuticals

Pharmafile

Eli Lilly and Nexus Pharmaceuticals have announced that they have entered into a definitive agreement for Eli Lilly to acquire a manufacturing facility from Nexus. The post Eli Lilly acquires new manufacturing facility from Nexus Pharmaceuticals appeared first on Pharmafile.

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Pfizer and BioNTech commence legal action against Moderna in UK court

Pharmaceutical Technology

Pfizer and its Germany partner BioNTech have urged London’s High Court to invalidate competitor Moderna's patents over technology instrumental in the Covid-19 vaccines development as the latest phase of a global legal fight that started yesterday (23 April), reported Reuters.

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New heart disease calculator more accurately predicts patients’ risk of CVDs

Pharma Times

According to the World Health Organization, CVDs are responsible for an estimated 17.

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[Podcast] Partner for Progress: Strategies for Biotech Success

BioPharma Dive

In this three-part podcast series, hear from seasoned experts from Allucent as they discuss a range of topics, including how small and mid-sized companies can take a more strategic approach to pharmacovigilance, a regulatory & development roadmap for ADCs and RDCs, and pre-MAA/NDA inspection readiness.

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Why healthcare is an easy target for cyberattacks

pharmaphorum

Explore why healthcare organisations are often targeted by cyberattacks and learn about the common vulnerabilities that make them susceptible to security breaches in this informative article.

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Biogen sees ‘encouraging’ trends for postpartum depression drug

BioPharma Dive

First quarter sales of Zurzuvae doubled consensus estimates, though analysts are skeptical whether the better-than-expected launch will continue.

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Proposal for practice pharmacists to carry out childminder health checks

The Pharmacist

Pharmacists working in GP practices could be enabled to complete health declarations for prospective childminders under new government proposals. The Department for Education (DfE) said widening the range of healthcare professionals who can complete health checks could ‘speed up the process and in some cases remove the burden on GPs’. The proposal comes as part […] The post Proposal for practice pharmacists to carry out childminder health checks appeared first on The Pharmacist.

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Biogen to invest more in launch of Alzheimer’s drug Leqembi

BioPharma Dive

Growing demand has convinced Biogen that it's worth expanding the sales force around Leqembi by 30%.

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Stuart Williams joins Fuld & Company as Senior Vice President, Client Growth & Strategy

Fuld & Company Blog

Stuart Williams, Senior Vice President, Client Growth & Strategy BOSTON – April 24, 2024 – Fuld & Company, an expanding research, analytics, and advisory consultancy, is pleased to welcome Stuart Williams as the Senior Vice President of Client Growth & Strategy. In this role, Stuart will spearhead the company’s business development and client engagements within the technology (ICT), healthcare, banking, and manufacturing sectors in North America.

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On the Same Page for the Future

PharmExec

In this Pharmaceutical Executive video interview, Jon Hamrick, Partner, Curatio Scientia Advisors and Jon Rawlson, President & Founder, Armory Hill Advocates, speak about what kind of impact their survey's findings impact will be on the industry.

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London ICB trialling retention scheme for practice pharmacists

The Pharmacist

North East London Integrated Care Board (ICB) has piloted a retention scheme for clinical pharmacists that offers them portfolio roles across general practice and specialist or academic work. In an interview with our sister title Healthcare Leader the ICB's chief executive Zina Etheridge said the area had particular issues with retention due to the difference […] The post London ICB trialling retention scheme for practice pharmacists appeared first on The Pharmacist.

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FDA Grants Accelerated Approval to Day One’s Ojemda for Relapsed or Refractory Pediatric Low-Grade Glioma

PharmExec

Ojemda is the first systemic therapy approved by the FDA for the treatment of relapsed or refractory pediatric low-grade glioma harboring a BRAF fusion or rearrangement, or a BRAF V600 mutation.

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MacroGenics gets grant for patent granted for compounds targeting IL23a and BAFF

Pharmaceutical Technology

Discover how MacroGenics Inc's patent for compounds targeting IL23A and BAFF can suppress inflammatory responses in subjects in need. Learn about the unique polypeptide compositions and methods outlined in the patent.

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RLS Treatment – Clinical Practice Pearls

Med Ed 101

Restless Legs Syndrome (RLS) can be very debilitating for patients. It is a condition that often warrants pharmacotherapy. But which medications are most effective and how should we choose? I’ll lay out some of the most important RLS treatment clinical pearls in this blog post. Dopamine Agonists Or Gabapentinoids For RLS? I remember a time […] The post RLS Treatment – Clinical Practice Pearls appeared first on Med Ed 101.

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