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Researchers identify ‘molecular switch’ in lupus that could stymie harmful immune response

STAT

But new research asks the question: What if immune cells could be turned back into good guys, and actually help save tissue damaged by autoimmune disease?    Lupus is complicated because it wields the body’s own defenses against itself, generating a continuous immune misfire.   Read the rest…

Immunity 361
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STAT+: Vertex to buy Alpine Immune Sciences for $4.9 billion

STAT

Vertex Pharmaceuticals will buy Alpine Immune Sciences, a maker of protein-based medicines that harness the immune system, for $4.9 billion, the companies announced Wednesday. It is the largest acquisition in Vertex’s history.

Immunity 352
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STAT+: Borrowing an idea from cancer immunotherapy, scientists make old-mice immune systems youthful again

STAT

Researchers studying the ways these systems change with age refer to them collectively as “immunosenescence,” or, more poetically, the “ twilight of immunity. ” But even as scientific understanding of the phenomenon has grown over the past decade, the forces driving it remain murky.

Immunity 331
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Smoking impairs immune response, even after quitting, new study says

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The study , published Wednesday in Nature, underscores the importance of never lighting up that first cigarette, based on its conclusion that smoking has much longer harmful effects on immune responses than previously understood. Read the rest…

Immunity 356
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STAT+: Moderna says data show its combination Covid-flu vaccine generates a strong immune response

STAT

Moderna announced Monday that, in a Phase 3 clinical trial, its combination Covid-19 and influenza vaccine generated stronger immune responses in older adults than individual vaccines that target those viruses.

Immunity 360
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STAT+: Like a vampire, some cancer cells can suck the energy source from immune cells

STAT

As elite hunters of the immune system, T cells are constantly prowling our bodies for diseased cells to attack. New research shows that some cancer cells can fire a long nanotube projection into the T cell that, like a vampire’s fang, sucks energy-creating mitochondria from the immune cell, turning the predator into prey.

Immunity 363
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STAT+: AltruBio raises $225 million to develop ulcerative colitis drug and other immune checkpoint enhancers

STAT

Checkpoint inhibitors, drugs that unleash the immune system, have turned into blockbuster therapies that have transformed outcomes for some patients with deadly cancers.

Immunity 281