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SAEM Clinical Images Series: Not Your Average Eczema

ALiEM - Pharm Pearls

He is up to date on childhood immunizations and is not prescribed any oral medications. 2011 Feb;40(2):167-9. Mom had been applying Aquaphor and Vaseline several times a day. On the day of presentation, he woke up with a new rash over his face and hands which prompted the ED visit. Studdiford JS, Valko GP, Belin LJ, Stonehouse AR.

Immunity 161
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SAEM Clinical Images Series: Not Your Average Ear Infection

ALiEM - Pharm Pearls

A 5-year-old generally healthy fully immunized boy presented to the ED with worsening left ear redness, swelling, and tenderness that his family noticed the day before presentation. 2011 Jan;13(1):21-4. His family had also recently noticed an abrasion over that ear. Treat this condition with anti-pseudomonal antibiotics.

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Early cell therapy successes start to turn the tide in lupus

Pharmaceutical Technology

In August 2021, Saphnelo, a type 1 interferon receptor antibody, became the first lupus treatment to be approved since GSK’s Benlyta (belimumab) won a regulatory nod in 2011. In lupus, the body’s immune system starts to attack its own cells. As per AstraZeneca's recent Q3 earnings, Saphnelo has yielded $69 million to date this year.

Immunity 144
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Re-engineering proteins to develop novel immunotherapies

European Pharmaceutical Review

The field of immunotherapy is constantly evolving with the ultimate goal to develop new treatments that help the body’s immune system fight cancer. Immune cells, such as T cells and natural killer (NK) cells, have the inherent ability to combat diseases, including cancer, but are often inhibited by the body’s own suppressive mechanisms.

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Understanding the microbiome as an ‘overlooked critical organ’

pharmaphorum

PubMed cites 1,822 pieces of research relating to the microbiome in 2011, which grew to 25,153 published in 2021. As more research has been conducted, closer and unexpected links have been found between the microbiome of the gut, as one example, and other areas of the body, such as brain health and the immune system.

Immunity 115
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BMS’ Orencia gets FDA nod for GvHD thanks to real-world data

pharmaphorum

Orencia (abatacept) becomes the first drug to be approved to prevent GvHD , a condition in which donor immune cells attack tissues in the patient receiving an HSCT, commonly known as a bone marrow transplant. billion in the first nine months of the year.

Immunity 105
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Data hackathon analyses truth behind TB vaccine and COVID-19

pharmaphorum

This century-old vaccine came to prominence recently, when a number of early ecological studies (those which study population factors in epidemiology) seemed to show a strong correlation between receiving the vaccine and having immunity against COVID-19. how long does the immunity from BCG last after that vaccination? For example.

Vaccines 110