Pharmaceutical Technology

JANUARY 22, 2023

In 2022, the FDA approved only 37 new medicines, an underwhelming number compared to 98 in 2018. However, while only around 34% of the approvals in 2018 were for orphan drugs, 54% new approvals in 2022 were for drugs to treat rare diseases. The FDA will weigh the concerns and benefits of this drug before its PDUFA date in October.

Communication 126

Communication Dosage Drug Development 126

PharmD Live

MAY 30, 2024

Medication Non-Adherence Polypharmacy increases the likelihood of medication non-adherence due to the complexity and confusion of managing multiple medications.Patients often struggle with the regimen, missing doses, taking incorrect dosages, or discontinuing medications altogether, which can lead to suboptimal treatment results.

Clinical Pharmacology 119

Clinical Pharmacology Hospitals Long-Term Care Facilities Dosage 119

RX Note

JANUARY 21, 2023

Regardless, this post is solely created as a collection of recommended reference.

Compounding 40

Compounding Community Pharmacies Clinical Pharmacology Dosage 40

The Thyroid Pharmacist

AUGUST 11, 2023

Recommendations for Those on T4-Only Medications T4-only medication (such as Synthroid, Levoxyl, Tirosint, Eltroxin, and generic levothyroxine) has a five- to nine-day half-life, which means that once you have become stable on the current dosage, it can take up to nine days for 50 percent of the dose to clear the body.

Dosage 98

Dosage Compounding Diabetes 98

European Pharmaceutical Review

MARCH 6, 2023

At Eisai, we believe that the most important factors for successful clinical trials are the four R’s: Right Hypothesis, Right Population, Right Dosage and Right Endpoint. He joined Eisai in 2018 as Vice President, Clinical Research for the company’s Epilepsy and Sleep/Wake therapeutic areas.

Dosage 96

Dosage 96

The Thyroid Pharmacist

OCTOBER 1, 2022

However, in this article, I offer a brief overview of each, along with recommended products and dosages. Please note: All dosage recommendations in this article are intended for adults. Precautions: Thiamine is generally safe if taken in the recommended dosages. Recommended Supplement: Benfomax from Pure Encapsulations.

Adverse Reactions 98

Adverse Reactions Dosage Immunity Immunization 98

RX Note

JUNE 7, 2023

NOTE: The FDA recommends rosuvastatin dosage reductions in Asian patients to maximum 20 mg daily because pharmacokinetic studies have demonstrated an approximate two-fold increase in median exposure to rosuvastatin in Asian subjects when compared to Caucasian controls. Stopping Statins?

Dosage 52

Dosage 52

RX Note

OCTOBER 9, 2023

If the drug level is found to be below or above the range, it will serve as a guide for dosage adjustment. Objectives For simplistic purpose, there are 3 different occasions where we choose to do a TDM: To ensure the narrow therapeutic window drug level is within therapeutic range.

Dosage 52

Dosage Clinic Management 52

pharmaphorum

SEPTEMBER 16, 2022

The question now is how to tailor dosage even more closely to fit patients’ needs. “[L]ess Lebrikizumab would be the second biologic Almirall has launched to market, following tildrakizumab’s commercialisation in 2018 for the treatment of moderate to severe plaque psoriasis. About the interviewee. Dr. Thyssen, MD, Ph.D.

Medical Schools 100

Medical Schools Hospitals Dosage Labelling 100

FDA Law Blog: Biosimilars

SEPTEMBER 23, 2024

Hatch passed away in April 2022), but Eli Mazour’s Clause8 podcast from October 2018 already covered that ground: see Henry Waxman – The Hatch-Waxman Act and a Life In Congress. So what should we do here on the FDA Law Blog to celebrate the 40th anniversary of Hatch-Waxman? We thought about an interview with Rep. Waxman (sadly, Sen.

Dosage 59

Dosage Drug Pricing 59

RX Note

JULY 12, 2023

However, in patients who insist on it, the following criteria must be considered first: Patients' BP must not be higher than stage I (mild) hypertension with low global CV risk BP well-controlled for at least 1 year on the same medication at the same dosage Must agree to be followed up at least 3-6 monthly Must be motivated to adopt healthy living (..)

Adverse Reactions 52

Adverse Reactions Dosage Diabetes 52

RX Note

MAY 27, 2023

The question seemed simple enough: whether dosage adjustments were needed for metronidazole in obese patient. Introduction I can still recall a memorable incident during my provisional registered pharmacist year when I received a phone call from a doctor during an on-call shift.

Dosage 52

Dosage 52

RX Note

AUGUST 4, 2023

In terms of knowledge, I generally divide the preparations into 2 key parts: Familiar yourself with common oral medications that you probably encounter in a daily basic (including both indications and dosage).

Hospitals 52

Hospitals Inpatient Community Pharmacies Dosage 52

RX Note

MARCH 10, 2023

Introduction In August 2018, I started a self-initiative drug database project, named "Rx". Uses and off-label use (with recommended dosage) Oral medication administration Advice to patients and Essential points, such as adverse drug reaction and role in therapy. The information is organised in following sequence (where appropriate).

Community Pharmacies 52

Community Pharmacies Hospitals Dosage Labelling 52

RX Note

JANUARY 11, 2024

The dosage of all products marketed for dry eye is largely dependent on the patient's need for lubrication, and is therefore given on an as-needed basis. External Links TFOS DEWS II Definition and Classification Report, 2017 Master the Maze of Artificial Tears, 2018 Artificial Tears: What Matters and Why, 2020

Diabetes 52

Diabetes Dosage Chemotherapy Community Pharmacies 52

The Thyroid Pharmacist

AUGUST 18, 2023

Research has shown plasma concentrations of curcumin as low as 50 ng/mL after administration of dosages as high as 12 g/day. The dosage I used when working to detox my body of arsenic was 500 mg, three times per day. Headaches and nausea have been noted in a small number of people at dosages over 450 mg. Published 2018 Feb 28.

Dosage 98

Dosage Compounding Labelling Diabetes 98

RX Note

FEBRUARY 26, 2023

Introduction Prefabricated transdermal patches are designed to deliver a constant and controlled dosage over extended periods for systemic therapy. They offer advantages over conventional oral dosage forms in that Drug administration through the skin avoids the pH variations seen with gastrointestinal transit.

Dosage 40

Dosage 40

European Pharmaceutical Review

MARCH 1, 2023

X-ray technology is also increasingly used in pharmaceutical R&D, particularly for examining solid dosage forms, an application for which this technology can be seamlessly adopted. X-ray Microtomography of Solid Dosage Forms. J Pharm Sci 2018; 107(11): 2810–22 [[link] 30005985] 7. Hancock BC, Mullarney MP.

Dosage 98

Dosage 98

Big Molecule Watch

SEPTEMBER 25, 2023

Last week, FDA released a draft guidance, “ Labeling for Biosimilar and Interchangeable Biosimilar Products ” (“2023 Draft Guidance”) that—when finalized—will revise and replace its July 2018 final guidance, “ Labeling for Biosimilar Products.”

Labelling 50

Labelling Biosimilars Adverse Reactions Dosage 50

Pharmacy Joe

JUNE 20, 2021

Drug interactions, lack of variety of dosage forms and decreased absorption threaten to expose patients to unintended monotherapy. Episode 619: Management of Antiretrovirals in Critically Ill Patients Subscribe on iTunes , Android , or Stitcher Management decisions regarding antiretroviral therapies in critically ill patients are complex.

Inpatient 40

Inpatient Dosage 40

RX Note

APRIL 20, 2023

Strong opioids, of which morphine is considered the gold standard, have no ceiling effect, and therefore increased dosage continues to give increased analgesia, but side effects often limit the effectiveness. If pain remains uncontrolled, then a weak opioid, such as tramadol, codeine or dihydrocodeine, may be helpful.

Diabetes 52

Diabetes Dosage Labelling 52

RX Note

MARCH 23, 2023

Contains specialized suspending system formulated to assist in extemporaneous preparation of oral liquid, non-soluble (suspended), aqueous dosage forms. X-Temp Oral Suspension System Orange flavoured, sweetened, sugar-free vehicle. Contains suitable preservatives: Methyl hydroxybenzoate, propyl hydroxybenzoate, potassium sorbate.

Compounding 52

Compounding Health and Personal Care Stores Hospitals Dosage 52

RX Note

APRIL 3, 2024

If response to a prostaglandin analogue is poor, switching to another one may be effective as drugs in this class are structurally different.

Dosage 52

Dosage Labelling Diabetes 52

RX Note

JUNE 21, 2023

External Links Clinical Pharmacy and Therapeutics, 2018 Clinical pharmacy services, pharmacy staffing, and hospital mortality rates, 2007 Patient counselling Assess and counsel patients on device techniques such as insulin or inhalers.

Hospitals 52

Hospitals Patient Counseling Inpatient Dosage 52

RX Note

JUNE 18, 2023

Dosage adjustment is required in renal impairment for alogliptin, sitagliptin, saxagliptin and vildagliptin. External Links Rang & Dale’s Pharmacology, 2019 Clinical Pharmacy and Therapeutics, 2018 Management of Type 2 Diabetes Mellitus, 2020 This in turn decreases blood glucose and increases insulin secretion.

Diabetes 52

Diabetes Dosage Hospitals 52

ID Stewardship

AUGUST 1, 2023

That is the driving force behind this series of articles which has been ongoing since 2018, bringing insights from Nigeria , India , Bangladesh , Uganda , Thailand , Japan , Costa Rica , Australia , New Zealand , Canada , Spain , and the United Kingdom. I graduated from Pharmacy in June 2014. and Enterobacterales in our hospitals.

Hospitals 98

Hospitals Community Pharmacies Dosage Communication 98

pharmaphorum

JUNE 1, 2021

According to the Alliance for Safe Online Pharmacies, 100% of online searches to buy medicine return links for illegal pharmacies, and in 2018 the US Food and Drug Administration estimated that only 3% of online pharmacies complied with US pharmacy laws and practice standards. About the author . appeared first on.

Online Pharmacies 52

Online Pharmacies Dosage Packaging Pharmaceutical Companies 52

Pharmaceutical Technology

JANUARY 6, 2023

Last week, Novartis announced plans to pay $245 million to end a pay-for-delay legal battle that started in 2018. At the centre of the case was Gilenya’s ‘405 patent, which details methods for treating relapsing multiple sclerosis with a specific dosage of the drug.

Documentation 97

Documentation Hospitals Dosage Drug Pricing 97

European Pharmaceutical Review

DECEMBER 5, 2024

Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice (2nd ed.). About the author Caterina Funaro is IMA Active Competence Center Manager and Coating Expert. References 1. Aulton, M E, Taylor, K M G. Aulton’s Pharmaceutics: The Design and Manufacture of Medicines (5th ed.). Lachman L, Lieberman H A, Kanig J L.

Packaging 52

Packaging Dosage Compounding 52

RX Note

MARCH 22, 2024

May allow a reduction in levodopa dosage. Apomorphine (intermittent SC injection or continuous infusion with a portable pump) Useful in people severely disabled by motor fluctuations refractory to conventional treatment. Is highly emetogenic and requires pre-treatment with domperidone to reduce nausea.

Dosage 40

Dosage Communication 40

European Pharmaceutical Review

DECEMBER 15, 2022

COMP360 capsules are an immediate‑release solid dosage form for oral administration, administered with psychological support. 2018 [Cited 2022Nov]. The study of 233 participants reported that almost 30 percent of patients who received a single 25mg dose of COMP360 psilocybin therapy were in remission by Week 3. 2014;11(101):20140873.

Dosage 69

Dosage Communication 69

RX Note

AUGUST 25, 2024

A quick question: Do you know the common dosage of St. 2018 Understanding complementary medicines, 2024 Herbs at a Glance Medline Plus - Herb Memorial Sloan Kettering Cancer Center - Herb University of Rochester Medical Center - Herb John's Wort or its typical uses? In university, we often highlighted St.

Diabetes 52

Diabetes Community Pharmacies Dosage Documentation 52

RX Note

JUNE 16, 2023

Water-soluble beta-blockers are excreted by the kidneys and dosage reduction is often necessary in renal impairment. Summary External Links Rang & Dale’s Pharmacology, 2019 Clinical Pharmacy and Therapeutics, 2018 GlobalRPH - ACE inhibitors med equivalent GlobalRPH - Angiotensin II Receptor Blocker med equivalent

Dosage 52

Dosage Diabetes 52

The Thyroid Pharmacist

NOVEMBER 4, 2022

For example, having people take therapeutic dosages of two nutrients, selenium and myo-inositol , in addition to working to balance their blood sugar, can work wonders at reducing their anxiety and OCD symptoms, as well as reducing their thyroid antibodies and thyroid symptoms. Recommended dosage and precautions. Hum Psychopharmacol.

Diabetes 98

Diabetes Dosage Compounding Immunity 98

The Thyroid Pharmacist

SEPTEMBER 20, 2024

One 2018 study found that among 80 people with IBS, 19 percent had undiagnosed thyroid dysfunction. [11] Be sure to work with your doctor or practitioner to determine the right supplements and dosages for you. Published 2018 Nov 28. Published 2018 Nov 5. Published 2016 Jun 27. doi:10.1038/nmicrobiol.2016.93 Freece.com.;

Health and Personal Care Stores 84

Health and Personal Care Stores Diabetes Chemotherapy Medication Therapy Management (MTM) 84

Quality Matters

MAY 17, 2023

and increased complexity of the manufacturing process Traditional medicines have been evolving into more complex, sophisticated drug products, dosage forms, and advanced therapies. In parallel, manufacturing technologies (including adoption of artificial intelligence, advanced computing, etc.)

Drug Development 52

Drug Development Dosage Pharmaceutical Manufacturing 52

Proxsys Rx

MARCH 23, 2023

Additionally , MedServRx enables patients to search for prescription discounts by dosage quantity (or volume) and by method of delivery (IE: capsules vs. liquid). The cost of prescription non-adherence to the community at large — which ultimately pays for uncompensated care (particularly for hospital readmissions) — is staggering.

Drug Pricing 52

Drug Pricing Hospitals Prescription Filling Dosage 52