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s CDC Vaccine Committee Overhaul for the Pharmaceutical Industry June 10, 2025 By Christopher Cole News Article The dismissal of all 17 members of the Advisory Committee on Immunization Practices has far-reaching impacts for the industry and beyond.
Opioid prescriptions for high dosages and quantities, including prescriptions that individually or in combination, provide patients with daily dosages of greater than or equal to 300 Morphine Milligram Equivalents (MMEs). 81, 89, 251.
Visually Impaired-Friendly Medicine Label Initiative In 2023, Malaysia Ministry of Health has introduced the Visually Impaired-Friendly Medicine Label Initiative (as an extension of the Know Your Medicines Programme) to help visually impaired patients in taking medicines. drug dosage) and the indications of medication (e.g.
In the autumn of 2023, the FDA’s Nonprescription Drug Advisory Committee convened to assess the status of oral phenylephrine under the ‘Generally Recognised as Safe and Effective’ (GRASE) category for nasal decongestion. Theresa Michele, M.D.,
AMH Aged Care Companion - Contains information on managing more than 70 common conditions in the elderly, with a focus on issues relevant to older people using medicines. Beyond these official sources, various healthcare societies and associations also contribute by publishing practical guides relevant to their specific disciplines.
It provides quick information on indications, dosage, availability and prescribing category. For drugs that are not available in the MOHMF , a separate drug list with detailed indication and dosage information should be created. These self-driven initiatives are infrequently updated and offer little additional value.
As environmental concerns continue to intensify, the pressure on the pharmaceutical industry to reduce its overall environmental impact, particularly in final dosage forms, is growing proportionately. In March 2024, Lonza hosted its first digital Responsible Supplier Event which brought together more than 1,100 participants.
This phase 1b clinical trial, conducted between September 2023 and November 2024, was designed to build on promising preclinical data that demonstrated improved efficacy and tolerability with continuous SC lenalidomide delivery in murine MM models. It will be interesting to see what dosage form these data prompt the future development of.
Other PrEP regimens on the market require daily oral dosages or shots every few months, but the latest version is only administered twice a year. Of the 13 antibiotics OK’d for the market between mid-2017 and 2023, only two belonged to a new class of drugs, the WHO reported last year.
Results American Oncology Network (AON) Pharmacy collected data on waste and cost avoidance from February 2023 to September 2023. If a discrepancy is found, the pharmacy nurses will hold the shipment, and a clinical intervention will be communicated to the provider. During this time frame, the pharmacy documented 152 interventions.
Additionally, ANDA submissions should extrapolate the RLD safety and effectiveness data for drugs with the same active ingredients, dosage forms, strengths, routes, and labeling. From 2003 to 2023, 943 drugs were approved through the 505(b)(2) pathway. However, 505(b)(2) drugs have been available since the 1980s.
Animal studies reveal dose-dependent hepatic responses to CBD, supporting the need for cautious monitoring even at consumer-relevant dosages. Pharmacists should review patient medication profiles, advise on appropriate dosage adjustments, and monitor for cumulative toxicity. of healthy adults, necessitating liver function monitoring.
This single-center, retrospective, observational study included data from electronic health records and specialty pharmacies from January 1, 2023, to June 1, 2024, with specialty pharmacy dispensing data specifically used to identify patients who had received Humira and a biosimilar during the study period.
Generics are exact chemical copies of small-molecule drugs, with identical active ingredients, strengths, dosage forms, and routes of administration. 7 In 2023, biosimilars contributed to nearly 500 million additional treatment days, improving access to essential therapies for patients who might otherwise go without.
2 Guiding prescribers and patients through initiation of lumatperone, adjusting dosage amounts, and switching from other antipsychotics, emphasizing its favorable relapse reduction profile is key in preventing relapse.
HME in drug manufacturing typically employs corotated twin extruders and uses heat and pressure to create solid dosage forms, dispersing the active pharmaceutical ingredient within a molten polymer matrix, and forming a solid solution or amorphous solid dispersion. It has been used frequently for manufacturing poorly soluble compounds.
A group of experts will present an encore abstract titled " Prevalence of Dosage Modifications and Impact on Response Milestone Among Patients With CML Treated With Imatinib Using Real-World Data " at the 2025 Oncology Pharmacists Connect (OPC) meeting in Austin, Texas, from June 19 to 20.
& Immunother. link] fimmu.2024.1427573 2024.1427573 4. and Shi, D. Targeted Nanoscale Drug Delivery Systems For Melanoma Therapy. & Tech. 86, 104724. link] org/10.1016/j.jddst.2023.104724
6 Chimeric antigen receptor (CAR) cell therapies ranked 10th with 795 candidates, holding steady from 2023. The approval of the first CRISPR-Cas9-based therapy in 2023 has accelerated efforts toward allogeneic, off-the-shelf CAR T products. 6 CAR T-cell therapies continue to dominate the genetically modified space. 2024;45(5):406-418.
1 "[Meloxicam injection] demonstrates our commitment to improving patient care by providing an alternate dosage form for pain management," Ron Scarboro, chief executive officer at Azurity Pharmaceuticals, said in a press release.
Ongoing partnership and past supply challenges AstraZeneca has been working hand-in-hand with Sanofi on the production front since its launch in 2023. As of now, supply for this coming season matches last year’s total dosage, with production expected to continue. over those aforementioned RSV seasons.
Around late 2023, a friend was diagnosed with metastatic colorectal cancer at 46 years old. I recently had the opportunity to blend my own science and philosophy at the Hematology/Oncology Pharmacy Association (HOPA) 2025 Annual Conference in Portland, Oregon, presenting on psychedelic medicines in oncology and palliative care.
Limitations included open-label design and dosage constraints, but the multicountry approach enhanced generalizability and external validity. All patients underwent a 20-week correction period for dosage titration and Hb correction, which was followed by an 8-week evaluation for efficacy assessments. Updated December 22, 2023.
By observing the microscopic effects of potential treatments, students will be able to gain insight into toxicity, dosage response, and disease progression. link] collaboration-between-indus- try-and-academia-in-drug-de- velopment/ Singh, N., Tsaioun, K., & Villoutreix, B. Frontiers in Drug Discovery, 3, Article 1201419. Zhang, H.,
In addition, the dosage [of 2000 IU per day] used in the research is far below the target dose for correcting vitamin D deficiency, which is usually 50,000 IU per week,” Carvalho-Pessoa said in a news release. 1,2 “Even with a small sample of participants, it was possible to observe a significant difference in the response to chemotherapy.
Selection of an appropriate OTC analgesic should take into consideration various patient factors, including the patient’s overall health status, current medical conditions, and medication profile, as well as patient preferences, which are often influenced by dosage form, required dosing intervals, and cost of OTC medication. November 6, 2023.
billion in 2023. Pfizer’s lower-dose version of tafamidis, sold under the brand Vyndamax, has a recommended dosage of 61 milligrams taken once daily as a single capsule. billion in 2023. It affects more than 120,000 US adults, according to non-profit researcher Institute for Clinical and Economic Review.
2023 39 (2), 102-116. Insights into Ocular Therapeutics: A Comprehensive Review of Anatomy, Barriers, Diseases, and Nanoscale Formulations for Targeted Drug Delivery. link] Gautam, M.; Intracameral Drug Delivery: A Review of Agents, Indications, and Outcomes. DOI:10.1089/jop.2022.0144 2022.0144 Natarajan, J.V.;
Steqeyma provides a new dosage form and strength, enhancing treatment flexibility for young patients with chronic inflammatory conditions. The biosimilar demonstrated comparable efficacy and safety to Stelara in a phase 3 clinical trial, supporting its FDA approval.
2,3 LIMBER is a phase 1, open-label, dose escalation study evaluating INCB057643 as a monotherapy at a dose escalation of 4 to 12 mg daily (part 1) or in combination with ruxolitinib at a dosage of 4 mg once daily and escalating to the maximum tolerated dose in part 1 (part 2). November 6, 2023. Wang ZQ, Zhang ZC, Wu YY, et al.
The investigators assessed a total of 90 patients who received talquetamab at a dosage of 0.8 mg/kg once every 2 weeks plus teclistamab at a dosage of 3.0 2 As a combination therapy, talquetamab and teclistamab show significant promise in the phase 1b/2 dose escalation and expansion in the RedirecTT-1 trial (NCT04586426).
In February 2023, CureVac closed a US$250 million public offering and has a strong cash position to continue the development of its promising pipeline (14, 16). Nature Reviews Drug Discovery 2023 22, 607-609. 2023 Etherna. Belgium-based eTheRNA was founded in 2013 and developed mRNA and LNP technologies. News Release.
Theramex Treatment for Osteoporosis in Postmenopausal Women Accepted by Scottish Medicines Consortium Patrick Lavery July 7th 2025 Article The company estimated that more than 1000 women in Scotland at very high risk of fracture would be eligible for treatment.
FDA Voucher Program Provides Shorter Drug Application Review Time Susan Haigney June 18th 2025 Article The Commissioner’s National Priority Voucher can be used by drug developers to participate in a novel priority program for shortened drug approval review time.
The additions come as Lilly last week flagged challenges to meet demand for the two drugs, especially as it makes six dosage forms of Mounjaro and four of Trulicity. The The company is expanding its manufacturing capacity for the two drugs through its facility in North Carolina, and doubling it by the end of 2023.
The insurer analyzed pharmacy and medical claims of nearly 170,000 people between July 2014 and December 2023 and found 58% did not complete a 12-week course of the medicines. Nearly one-third halted treatment within four weeks, before recommended dosages reached the targeted strength.
Biocon recently announced that its step-down, wholly-owned subsidiary, Biocon Generics has acquired Eywa Pharma’s oral solid dosage manufacturing facility, located in Cranbury, New Jersey, US, effective September 1, 2023. A company statement informed, “The facility is acquired for a total consideration of $7.7
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