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FDA drug dosage optimisation guidelines signal clinical trial reform

Pharmaceutical Technology

They state that newer drugs like monoclonal antibodies and kinase inhibitors may benefit from a drug optimisation approach due to their different dose escalation profiles, compared to the cytotoxic chemotherapy drugs. Ratain says achieving the right dosage requires an understanding of clinical pharmacology and a randomised trial.

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Aminoglycosides Pharmacology!

PharmaFactz

Clinical Pharmacology When we talk about the clinical pharmacology of aminoglycosides, we need to think about the following factors: Nephrotoxicity is accompanied by reduced urine production, elevated serum creatinine levels and rising urea levels. Ototoxicity often presents in the post-infection phase.

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Uncovering the potential of ADCs to target tumours

European Pharmaceutical Review

1,2 This is especially important in forms of cancer where chemotherapy remains the main treatment option. Because ADCs offer a good way to specifically deliver an effective treatment to tumour systems, this could be an improvement on the systemic impact of chemotherapy.

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Methotrexate Pharmacology!

PharmaFactz

Methotrexate Pharmacology Here, we review the must-know facts about methotrexate pharmacology; an important drug that carries with it significant risks that healthcare professionals must be cognisant of. In this review, we learn more about the drug’s indications, mechanism of action, side effects, and clinical pharmacology.