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Alkem Laboratories, has entered into a licensing agreement with US-based Sonnet BioTherapeutics Holdings to develop, manufacture and commercialise the drug candidate SON-080 for the treatment of diabetic peripheral neuropathy in India. Diabetic peripheral neuropathy primarily affects the hands and lower limbs. “SON-080”
The techs who were queried identified chemotherapies; ADHD medicines; three drugs for weight loss and diabetes — Mounjaro, Ozempic, and Wegovy — and local anesthetics such as lidocaine as the top drugs experiencing shortages.
After a few victories he’s claimed, he’s now progressed to demanding that Novo Nordisk cut its price for its novel, wildly popular diabetes and weight loss drugs. Sanders (I-Vt.) is testing the limits of the powers of a Senate chairman with little hope of advancing his policy agenda legislatively. AstraZeneca is investing $1.5
Injectable diabetes medications including semaglutide, namely Wegovy and Ozempic, have been in shortage since 2022 , limiting patient access to the drug across the nation. Many other drugs have appeared on FDA’s shortage list in the past few years, including ADHD medications, chemotherapy treatments, and even antibiotics.
Chemotherapy, medication for attention deficit/hyperactivity disorder, glucagon-like peptide-1 agonists for weight loss and diabetes, and local anesthetics were among the drugs most affected by shortages.
months and an objective response rate (ORR) of 48%, both exceeding what is typical for the standard of care of gemcitabine + nab-paclitaxel suggesting potential complementary activity with the existing FDA-approved standard chemotherapy regimen. The post Panbela announces issuance of key patent in Japan appeared first on Express Pharma.
PAVBLU is further indicated for the treatment of visual impairment due to diabetic macular oedema (DME). If approved, Amgens PAVBLU and SKOJOY would be the fifth and sixth aflibercept biosimilars approved in the EU, following the approval of Biocons YESAFILI , Sandozs AFQLIR , Samsung Bioepiss OPUVIZ , and Formycons FYB203.
Data from trials of the drug wowed ESMO in September – Trodelvy was shown to significantly extend overall survival (OS) and improved overall response rate (ORR) and clinical benefit rate (CBR), compared with standard chemotherapy in TNBC patients with brain metastases treated with at least two therapies. months, compared with 6.7
Imfinzi (durvalumab) has been cleared by the US regulator for the treatment of adult patients with locally advanced or metastatic BTC in combination with gemcitabine/cisplatin chemotherapy, extending the use of Imfinzi beyond lung cancer for the first time.
Last month, it also bought Impeto Medical to claim ownership of its Sudoscan device for detecting nerve damage affecting patients with diabetes or those who are getting chemotherapy for cancer.
Historically, dry eye disease (DED) has been classified into 2 general groups: Aqueous deficient DED Decreased tear production due to Sjogren's syndrome, older age and diabetes mellitus. Medical conditions Patients with rheumatoid arthritis , diabetes or thyroid problems are more likely to experience dry eyes.
Additionally, I developed a nonsterile compounding formulation for lidocaine popsicles to pair with the hazardous sterile chemotherapy for the oncology week. Her research interests include diabetes, practice advancement, post-graduate training, and Scholarship of Teaching and Learning (SoTL).
The company is also developing pipeline products for the treatment of cancer, Crohn’s disease, anemia, diabetes, atopic dermatitis, chronic bone disease, blood pressure, and hypercholesterolemia. Its product portfolio includes anti-tumor drugs, surgical drugs, contrast agents, angiomyocardiac drugs, and antibiotics.
Myo-inositol has been found to provide many valuable health effects, including anti-inflammatory, anti-oxidant, anti-diabetic, and anticancer effects. (7). They also concluded that patients testing with positive thyroid antibodies should be followed closely for diabetes mellitus and cardiovascular events. (1)
Scottish projects are already showing significant potential in diagnosing and treating conditions such as liver fibrosis, dementia, multiple sclerosis, cancer, and diabetes. At the core of health innovation in Scotland is the collaboration between industry, academia, and government.
Diabetic Neuropathy Diabetic neuropathy, a common complication of long-term high blood sugar and insulin resistance, can cause constipation. 88] This can be particularly beneficial in managing slow digestion often seen in diabetic gastroparesis. Diabetic neuropathy in the gut: pathogenesis and diagnosis. J Clin Med.
You may also refresh knowledge of clinical pharmacokinetics , total parenteral nutrition or chemotherapy before entering the relevant rotations. You should be at least familiar with insulin and inhalers counselling before entering ward, inpatient or outpatient. What to do if I did not know the answer to questions from patients or doctors?
Traditional therapies have included multi-kinase inhibitors, chemotherapy, and symptom-directed treatments. Toleikis, President & CEO at Sernova Shares Insights on the Partnership with Evotec to Develop a ‘Functional Cure’ for Diabetes
Traditional therapies have included multi-kinase inhibitors, chemotherapy, and symptom-directed treatments. Toleikis, President & CEO at Sernova Shares Insights on the Partnership with Evotec to Develop a ‘Functional Cure’ for Diabetes
Ministry of Health Systemic Therapy Protocol 2016 Ministry of Health Systemic Therapy Protocol focuses on chemotherapy and targeted therapies used in the treatment of solid tumours. However, in reality, chemotherapy regimen is not very different from how we manage a hypertension or diabetes mellitus.
Vitamin D supplementation increased 25-hydroxyvitamin-D levels significantly, suggesting a potential role in enhancing chemotherapy effectiveness. The study's findings support further research with larger samples to explore vitamin D's impact on chemotherapy and breast cancer remission likelihood.
Benmelstobart (TQB2450; Chia Tai Tianqing Pharmaceutical Group Co, Ltd) in combination with chemotherapy followed by sequential combination with anlotinib (Catequentinib; Advenchen Laboratories) led to significant improvements in progression-free survival (PFS), with a manageable safety profile. months versus 7.79 months with tislelizumab.
SHOW MORE New research reveals a significant link between type 2 diabetes, obesity, and fatty liver disease. Emerging study findings from investigators at Linköping University discovered that 6 out of 10 individuals with type 2 diabetes (T2D) had fatty liver.
1 Biomarker testing is relatively new in the treatment landscape for NSCLC but has proven incredibly important for personalizing patient care, transforming from a generic chemotherapy approach to a highly personalized, genomically driven treatment strategy. For advanced disease, chemotherapy was the standard.
Transportation barriers, as a health-related social need, significantly impact FN rates in chemotherapy patients. Febrile neutropenia (FN) remains a serious and common complication of chemotherapy. A 67% FN rate difference between pegfilgrastim and filgrastim was observed in patients with transportation barriers.
The medicines – which include insulin, oral diabetes agent glibenclamide and cancer chemotherapy oxaliplatin – will be sold under a new Impact brand and are all classed as essential medicines by the World Health Organisation (WHO).
They are also more likely to have diabetes, pain, and disability than other groups. Improving cultural humility in pharmacy education: a focus on diabetes management during religious fasting. 11 STEPPING UP A LEVEL Pharmacy teams can also speak to and for their communities. Pharmacotherapy. 2007;27(7):1062-1079. doi:10.1592/phco.27.7.1062
Mok : Right now, we have a lot of chemotherapy being used, but there are many more novel treatments being studied, especially in earlier lines of treatment. Bispecifics are moving up in the lymphoma space, and these newer therapies may have some synergistic effects with chemotherapy. REFERENCES 1. Updated August 18, 2021.
Datopotamab deruxtecan-dlnk (Datroway, Daiichi Sankyo, Inc) received FDA approval for treatment of adults with locally advanced or metastatic epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) who have received prior EGFR-directed therapy and platinum-based chemotherapy.
The study showed that adding Nubeqa to standard therapy with anti-androgen drugs and chemotherapy with docetaxel reduced the risk of dying by 32.5% compared to standard therapy alone. There was also a big increase in the duration of response, from a media of just under 17 months to 41 months.
For example, CPAs are especially impactful in managing chronic conditions such as diabetes, heart failure, and rheumatoid arthritis, where pharmacist intervention has been shown to improve outcomes and reduce hospitalizations. Creating disease-specific competency assessments also ensures alignment with evolving standards of care.
When this happens, the first line of drug treatment for hormone-sensitive tumours is ADT, with chemotherapy layered on top if needed. Around 95% of prostate cancers are localised at diagnosis and treated with surgery or radiotherapy, but tend to relapse.
Related Videos Related Content Advertisement June 9th 2025 Neoadjuvant Nivolumab With Chemotherapy Yields Significant Overall Survival Benefit in Resectable NSCLC Luke Halpern, Assistant Editor June 3rd 2025 S2. N Engl J Med. 2019;380:2020-2030. Subscribe Now!
Approximately 40% to 80% of patients with cancer who are assigned female at birth face possible infertility as a result of their cancer treatments, such as chemotherapy, radiation, and surgery. An additional 15% to 30% of cancer survivors who are assigned male at birth also face infertility as a result of chemotherapy.
4 Notably, microbiome therapies have strong potential in onco-haematology, where antibiotic and chemotherapy-derived loss of gut diversity is predictive of mortality in patients who have undergone an allogeneic haematopoietic stem cell transplant, as well as GvHD occurrence and infection. Internet] Pharmaceutical Technology. cited 2024Feb].
4 Nononcology applications are growing, however, particularly for conditions such as osteoarthritis, type 1 diabetes, and Parkinson disease. CD19-directed CAR T therapy has shown promising outcomes in systemic lupus erythematosus, prompting more than a dozen trials targeting lupus, type 1 diabetes, myasthenia gravis, and multiple sclerosis.
Yes, we currently have antibody-drug conjugates that are conjugated to a cytotoxic chemotherapy. So are there oncogenic proteins that we can actually target that we couldn’t traditionally target with just a small molecule inhibitor? We look at ADCs. Unfortunately, these drugs are quite toxic.
Conclusions We demonstrated the feasibility of leveraging a complex EHR data source from an integrated health system to study the impact of dose modifications on clinical outcomes for self-administered chemotherapy. Nearly half of the patients with CML on imatinib experienced dosage modifications in this study.
Keytruda is indicated in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) in patients whose tumors express PD-L1 and who have received at least one prior chemotherapy regimen. It is also indicated for the treatment of metastatic transitional (urothelial) tract cancer and gastric cancer.
1,2 MASH, formerly known as nonalcoholic steatohepatitis, is a severe form of metabolic dysfunction-associated steatotic liver disease (MASLD) that often accompanies various metabolic diseases (eg, obesity and diabetes). Major risk factors of HCC are metabolic dysfunction-associated steatohepatitis (MASH) and viral hepatitis.
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