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Aminoglycosides Pharmacology!

PharmaFactz

This transport system is not present in anaerobic or Streptococci bacteria – meaning these bacteria have intrinsic resistance to these drugs. Ototoxicity often presents in the post-infection phase. Mechanism of action Aminoglycosides are protein synthesis inhibitors. Affected persons may experience tinnitus, hearing loss and vertigo.

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Alzheimer’s drug requires strengthened pharmacovigilance approach

European Pharmaceutical Review

A paper published by the Drug Safety Research Unit (DSRU) in the British Journal for Clinical Pharmacology , has asserted the need for ongoing assessment of the safety and effectiveness of the Alzheimers drug lecanemab in the real-world clinical setting.

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Zydus receives USFDA approval to conduct Phase II(b) clinical trial for Usnoflast, a novel oral NLRP3 inflammasome inhibitor in patients with ALS

Express Pharma

Zydus has previously completed a Phase 2(a) randomised, double-blind, placebo-controlled clinical trial in 24 ALS patients across 7 clinical trial sites in India. It is planned to present this Phase 2(a) trial data in an upcoming medical conference and publish in a medical journal. DOI: 10.1002/cpdd.1162 DOI: 10.1002/cpdd.1318.

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ACMT Toxicology Visual Pearl: Who Doesn’t Like a Nice Rosé?

ALiEM - Pharm Pearls

What clinical presentation and medication is associated with this urinary discoloration? Hypersensitivity reactions to rifampin: Pathogenetic mechanisms, clinical manifestations, management strategies, and review of the anaphylactic-like reactions. Medicine (Baltimore) 1999;78(6):361-9. PMID 10575418 Kaakkola S.

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Aminoglycosides Pharmacology!

PharmaFactz

This transport system is not present in anaerobic or Streptococci bacteria meaning these bacteria have intrinsic resistance to these drugs. Ototoxicity often presents in the post-infection phase. Mechanism of action Aminoglycosides are protein synthesis inhibitors. However, aerobic Gram-negative bacteria do have this transport system.

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FDA drug dosage optimisation guidelines signal clinical trial reform

Pharmaceutical Technology

Ratain says achieving the right dosage requires an understanding of clinical pharmacology and a randomised trial. The clinical pharmacology knowledge also isn’t present at smaller companies, he adds. The MTD model made sense for early cancer studies when most drugs had non-specific targets, says Veal.

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The future of medical cannabis development in Europe

European Pharmaceutical Review

Cannabis complications There are notable complexities to researching medical cannabis using a linear approach to clinical translation. 5 These are each present at varying concentrations depending on underlying plant genetics and growing conditions. Expert Review of Clinical Pharmacology. British journal of pharmacology.