This site uses cookies to improve your experience. To help us insure we adhere to various privacy regulations, please select your country/region of residence. If you do not select a country, we will assume you are from the United States. Select your Cookie Settings or view our Privacy Policy and Terms of Use.
Cookie Settings
Cookies and similar technologies are used on this website for proper function of the website, for tracking performance analytics and for marketing purposes. We and some of our third-party providers may use cookie data for various purposes. Please review the cookie settings below and choose your preference.
Used for the proper function of the website
Used for monitoring website traffic and interactions
Cookie Settings
Cookies and similar technologies are used on this website for proper function of the website, for tracking performance analytics and for marketing purposes. We and some of our third-party providers may use cookie data for various purposes. Please review the cookie settings below and choose your preference.
Strictly Necessary: Used for the proper function of the website
Performance/Analytics: Used for monitoring website traffic and interactions
3 The guideline presents 12 voluntary, evidence-based suggestions for opioid management. 4 It encourages increased use of nonopioid pharmacologic and nonpharmacologic therapies, initiation of immediate-release opioids only when necessary at the lowest effective dose, and frequent reevaluation of therapy goals, function, and risk.
It will be interesting to see what dosage form these data prompt the future development of. It also introduces a question on how to optimize the PK/pharmacodynamic profile for protein degraders, such as cereblon E3 ligase modulatory drugs and proteolysis-targeting chimeras, which are a burgeoning area of therapeutic development.”
Animal studies reveal dose-dependent hepatic responses to CBD, supporting the need for cautious monitoring even at consumer-relevant dosages. Clinical trials show low-dose CBD can cause significant liver enzyme elevations in 5.6% of healthy adults, necessitating liver function monitoring.
link] Seasonal influenza vaccine dosage & administration. September 17, 2024. Accessed May 29, 2025. link] RSV vaccine guidance for older adults. August 30, 2024. Accessed May 29, 2025. October 16, 2024. Accessed May 29, 2025. link] US FDA approves BLA for Novavax’s COVID-19 vaccine. News release. May 19, 2025. Accessed May 29, 2025.
Additionally, ANDA submissions should extrapolate the RLD safety and effectiveness data for drugs with the same active ingredients, dosage forms, strengths, routes, and labeling. In the 505(j) ANDA approval pathway, on the other hand, submissions can be multisource generic drugs; however, this pathway requires bioequivalence to the RLD.
SHOW MORE Real-world data shows patients switching from Humira to biosimilars Hadlima and Hyrimoz achieve similar outcomes without hospitalization. The study's primary objective was to assess reversion rates to Humira, with 9% reverting after three months, while 91% remained on biosimilars or switched to alternatives.
Relapse risk factors include prior hospitalizations, long illness duration, and antipsychotic polypharmacy, emphasizing the need for effective maintenance treatments. Maintaining stability in schizophrenia is a major clinical challenge—each relapse can disrupt functioning, burden caregivers, and elevate hospitalization risk.
Generics are exact chemical copies of small-molecule drugs, with identical active ingredients, strengths, dosage forms, and routes of administration. Although generics and biosimilars offer lower-cost alternatives to brand-name drugs, they are not the same.
HME in drug manufacturing typically employs corotated twin extruders and uses heat and pressure to create solid dosage forms, dispersing the active pharmaceutical ingredient within a molten polymer matrix, and forming a solid solution or amorphous solid dispersion. trillion economic impact in 2020. trillion economic impact in 2020.
Side effects can interfere with daily life, reduce quality of life, and even cause patients to reduce the dosage or discontinue the drug completely.¹ Impact of oral naloxegol vs subcutaneous methylnaltrexone in treatment of opioid-induced constipation in the hospital setting. European Journal of Pharmacology. 2021;903:174132.
By incorporating a patient's genetic profile into therapeutic decision-making, pharmacists can identify optimal drug choices and dosages while minimizing the risk of adverse events (AEs). This is particularly vital in polypharmacy scenarios, where the risk of drug-drug interactions and cumulative toxicity is high.
A group of experts will present an encore abstract titled " Prevalence of Dosage Modifications and Impact on Response Milestone Among Patients With CML Treated With Imatinib Using Real-World Data " at the 2025 Oncology Pharmacists Connect (OPC) meeting in Austin, Texas, from June 19 to 20.
The study emphasizes the importance of pharmacist involvement in monitoring cognitive risks and managing long-term gabapentin therapy. Despite observational evidence, causation is not established, necessitating further research on dosage effects and neurocognitive outcomes.
The convenience of once-daily dosing and a rapid IV bolus administration may offer workflow efficiencies in hospital or surgical settings, where minimizing polypharmacy and streamlining medication administration are important goals.
Limitations included open-label design and dosage constraints, but the multicountry approach enhanced generalizability and external validity. All patients underwent a 20-week correction period for dosage titration and Hb correction, which was followed by an 8-week evaluation for efficacy assessments.
1 A total of 80 women aged 45 and older who were starting treatment at the oncology outpatient clinic of the hospital at FMB-UNESP were included in the randomized clinical trial. 1,2 “Even with a small sample of participants, it was possible to observe a significant difference in the response to chemotherapy. P = 0.04).
Selection of an appropriate OTC analgesic should take into consideration various patient factors, including the patient’s overall health status, current medical conditions, and medication profile, as well as patient preferences, which are often influenced by dosage form, required dosing intervals, and cost of OTC medication.
1 Omega-3 fatty acids and vitamin D are promising adjuncts for managing inflammation and improving outcomes in patients with RA. Pharmacists can play a pivotal role in guiding safe, evidence-based supplementation by recommending appropriate dosages, monitoring for interactions, and reinforcing adherence.
Steqeyma provides a new dosage form and strength, enhancing treatment flexibility for young patients with chronic inflammatory conditions. 1,4-6 "Managing inflammatory diseases in pediatric patients can be particularly complex," Hetal Patel, PharmD, MBA, vice president of medical affairs at Celltrion USA, said in a news release.
2,3 LIMBER is a phase 1, open-label, dose escalation study evaluating INCB057643 as a monotherapy at a dose escalation of 4 to 12 mg daily (part 1) or in combination with ruxolitinib at a dosage of 4 mg once daily and escalating to the maximum tolerated dose in part 1 (part 2).
The investigators assessed a total of 90 patients who received talquetamab at a dosage of 0.8 mg/kg once every 2 weeks plus teclistamab at a dosage of 3.0 2 As a combination therapy, talquetamab and teclistamab show significant promise in the phase 1b/2 dose escalation and expansion in the RedirecTT-1 trial (NCT04586426).
As depicted in Table 2 , if all of the following are true, then it is essentially a copy : same active pharmaceutical ingredient (API), same or easily substitutable dosage strength (this is set at greater than ±10%), and can be used by the same route of administration as prescribed for the compounded drug.
1 About the Author Monica Holmberg, PharmD, BCPS, is a pharmacist in Phoenix, Arizona, and a Pharmacy Times contributor. DOSAGE AND ADMINISTRATION The recommended dose of gepotidacin is 1500 mg orally twice daily for 5 days. The medication should be taken after a meal to reduce gastrointestinal intolerance.
I was a staff pharmacist working in my first hospital. This was even before I became a pharmacymanager. I liked working as a staff pharmacist in a hospital. It was just me and the pharmacy tech working that evening. Most of them were written by residents in the hospital. A 5ml dosage contains 1.8g
Medication adherence helps prevent exacerbations and hospitalizations, enhancing the patient’s quality of life. 3) Controlling Cholesterol Levels Statins and other lipid-lowering medications are crucial for managing cholesterol levels and preventing atherosclerosis.
Medication adherence helps prevent exacerbations and hospitalizations, enhancing the patient’s quality of life. 3) Controlling Cholesterol Levels Statins and other lipid-lowering medications are crucial for managing cholesterol levels and preventing atherosclerosis.
We organize all of the trending information in your field so you don't have to. Join 11,000+ users and stay up to date on the latest articles your peers are reading.
You know about us, now we want to get to know you!
Let's personalize your content
Let's get even more personalized
We recognize your account from another site in our network, please click 'Send Email' below to continue with verifying your account and setting a password.
Let's personalize your content