Wed.May 08, 2024

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Large amount of bird flu virus in milk suggests asymptomatic cows are infected with H5N1

STAT

Since March, when the first reported cases of H5N1 bird flu began showing up in dairy cattle in Texas, the Food and Drug Administration has been asking farmers to discard any milk from infected animals. Initially, spotting tainted milk was believed to be fairly easy because cows that get sick with H5N1 begin producing milk that is thick and yellowish.

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AZ oncology chief says AI can help solve cancer’s ‘ZIP code lottery’ as health disparities persist

PharmaVoice

Partnerships have been key to building the company’s AI capabilities and patient-focused R&D, said AstraZeneca’s head of U.S. oncology.

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STAT+: Gene therapy trial targeting rare form of deafness shows ‘jaw-droppingly good’ results

STAT

Two congenitally deaf children can hear for the first time after being treated with gene therapy, according to data presented at a conference Wednesday. The results are “jaw-droppingly good, just shocking how good. It exceeded the wildest expectations of anybody who started this work,” said Larry Lustig, an otolaryngologist at Columbia University and an investigator on the study.

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Chiesi and Gossamer collaborate to develop drug to treat respiratory diseases

Pharma Times

Gossamer’s seralutinib is designed to treat pulmonary arterial hypertension and other indications

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Navigating Payroll Compliance: Future-Proofing Payroll in an Evolving Regulatory Landscape

Speaker: Jennifer Hill

Payroll compliance is a cornerstone of business success, yet for small and midsize businesses, it’s becoming increasingly challenging to navigate the ever-evolving landscape of federal, state, and local regulations. Mistakes can lead to costly penalties and operational disruptions, making it essential to adopt advanced solutions that ensure accuracy and efficiency.

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STAT+: In fundamental advance, Google says AlphaFold 3 can map a vast universe of biomolecules

STAT

Google on Wednesday unveiled an artificial intelligence tool capable of predicting the structure and interaction of a vast universe of biomolecules, a fundamental advance that may help scientists unravel poorly-understood aspects of biology and disease. The new AI, dubbed AlphaFold 3, improves upon earlier versions of the model by predicting not just the structure of proteins, but all the molecules that interact with them in cells, including RNA, DNA, ions, and other small molecules.

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Johns Hopkins scientists depict molecular pathway to track replication in cancer cells

Pharma Times

The findings could potentially lead to new therapies and could stop the growth of cancers

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More Trending

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Drug patents protect pharma profits. Track when they’ll expire here.

BioPharma Dive

Intellectual property is the foundation of the drug industry’s business model. This database will track key patent expiry dates for 30 top-selling medicines.

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STAT+: A nonprofit does deals in Brazil and India to make low-cost CAR-T cell therapies widely available

STAT

In the latest bid to widen access to medicines, a nonprofit is sending technology and materials for making expensive CAR-T cell therapies to the Brazilian government and an Indian manufacturer that will, in turn, look to provide the treatments available at a fraction of current prices in the U.S. The deals will initially involve manufacturing cell therapies for combating lymphoma and leukemia, which carry price tags in the hundreds of thousands of dollars in wealthy nations.

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Regeneron gene therapy restores hearing in deaf child

pharmaphorum

Regeneron’s gene therapy for otoferlin-related hearing loss restored hearing to normal levels in one profoundly deaf child within just 24 weeks

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Cell therapy fails to slow early type 1 diabetes, but safety is established

STAT

Tolerance is the holy grail in calming autoimmune disease, a truce in the immune system’s faulty battle against the body’s own fabric. In type 1 diabetes, immune fighters attack beta cells in the pancreas that produce insulin, the hormone that controls glucose levels in the blood. Scientists have tried to enlist defenders in the form of regulatory T-cells, or Tregs, extra white blood cells whose job is to tamp down the misguided immune response.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Potential best-in-class antibody shows “remarkable efficacy” in atopic dermatitis

European Pharmaceutical Review

New data from a Phase IIa trial in moderate-to-severe atopic dermatitis has demonstrated that a novel monoclonal antibody (mAb) could facilitate dosing every 12 weeks for induction therapy. This is due to a 31-day half-life at anticipated therapeutic dose levels, Inmagene Biopharmaceuticals confirmed. Humanised anti-OX40 IgG1 mAb IMG-007 works via a silenced antibody -dependent cellular cytotoxicity (ADCC) function, Inmagene explained.

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Opinion: Listen: Why rehabilitation engineers need to listen to patients and their families

STAT

In 2020, James Sulzer’s personal and professional lives suddenly intersected after his then 4-year-old daughter sustained a devastating injury. As a researcher and associate professor in physical medicine and rehabilitation at Case Western Reserve University, Sulzer has spent his life tinkering with tools that help patients with neurological conditions.

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Spectral AI nears first sales of wound care system

pharmaphorum

The first commercial sales of Spectral AI's DeepView wound imaging system for burns are due to start in the UK, its first market, later this year

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Pharma has over $500B in capital for deals

STAT

Want to stay on top of the science and politics driving biotech today?  Sign up  to get our biotech newsletter in your inbox. Good morning. Today we ponder, how much will the advisory committee meeting for Lilly’s donanemab matter? Send me your thoughts, and as always, any ideas or tips:  elaine.chen@statnews.com.

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Why Every Small Business Needs an HCM Solution: A Comprehensive Guide

Managing HR tasks like payroll, compliance, and employee data can overwhelm small businesses. That’s where a Human Capital Management (HCM) solution comes in. Our eBook, Why Every Small Business Needs an HCM Solution: A Comprehensive Guide , shows how an HCM system automates tedious processes, ensuring your business stays compliant and efficient. You’ll learn how to simplify payroll, eliminate costly errors, and empower your employees with self-service tools.

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12 Questions with Ariel Buda-Levin

pharmaphorum

Get to know Ariel Buda-Levin from the IPG Health Network better with these 12 insightful questions. Learn more about her background, expertise, and experiences.

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AstraZeneca to withdraw Covid-19 vaccine globally

Pharmaceutical Technology

AstraZeneca has begun the global withdrawal of its Covid-19 vaccine Vaxzevria, citing a surplus of updated vaccines.

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Pharma gets ruthless as job losses mount across industry

pharmaphorum

As pharma R&D jobs face deep cuts, workers struggle with an uncertain future. Can the industry recover or will more jobs disappear?

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AMR support tools 'critically important' for pharmacist prescribers

The Pharmacist

The government has pledged to support pharmacist prescribers with tools to reduce unnecessary antimicrobial prescriptions as part of its five-year plan to tackle antimicrobial resistance (AMR). Such tools could make use of digital technologies including artificial intelligence (AI), but this would depend on ‘fully integrated digital systems’ with the right data governance permissions, the government said. […] The post AMR support tools 'critically important' for pharmacist prescr

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Best Practices to Streamline Compensation Management: A Foundation for Growth

Speaker: Joe Sharpe and James Carlson

Payroll optimization can be one of the most time-consuming and complex factors of small business management. Yet, organizations that crack the code on streamlining employee compensation often discover innovative avenues for growth. With the right strategies in place, outsourcing and streamlining payroll processes can result in substantial time and resource savings.

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Clinical trials: Their design, location, and, potentially, their simulation

pharmaphorum

Clinical trials, their design and location, and these days their simulation, are the focus of today’s podcast with Dr Gen Li, founder and president of Phesi.

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Data for First-in-Class IV-Administered Gene Therapy to Treat Epilepsy Presented at ASGCT 2024

PharmaTech

The company is presenting preclinical data at the American Society of Gene & Cell Therapy annual meeting that supports the potential of the company’s CAP-002 gene therapy for correcting neurological phenotypes associated with genetic epilepsy due to syntaxin-binding protein 1 (STXBP1) mutations.

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Pharmacies told to withdraw training placements lacking a DPP

The Pharmacist

Community pharmacies who are not able to provide trainee pharmacists with a designated prescribing practitioner (DPP) for the foundation year 2025/2026 should withdraw their application to provide a placement, the National Pharmacy Association (NPA) has warned. NHS England has previously encouraged members to express an interest in providing a placement 'even if they did not […] The post Pharmacies told to withdraw training placements lacking a DPP appeared first on The Pharmacist.

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RNA blood test may predict antidepressant response

pharmaphorum

Selective serotonin reuptake inhibitors (SSRIs) are the first-line drug therapy of choice for most people suffering from depression but often fail to work effectively. Now, a study suggests simple blood test could help predict those who will benefit.

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Enhance Healthcare Efficiency With Top Payroll & HCM Services

Running a healthcare facility requires precision and care, not just for patients but also for your staff. Our guide, "A Buyer’s Guide to Payroll & HCM Services," helps healthcare providers choose the best provider. Efficient payroll management ensures timely, accurate payments, critical for maintaining staff morale and trust. Compliance support helps navigate complex healthcare regulations and avoid costly fines.

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ESCMID 2024: Emerging bacterial infections in neonates and children

Pharmaceutical Technology

Coinfections can complicate disease management and hence continued surveillance and targeted intervention strategies are needed.

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US FDA to Review Eli Lilly’s Donanemab for Early Alzheimer’s Treatment

Express Pharma

The US Food and Drug Administration (FDA) will convene an in-person meeting of the Peripheral and Central Nervous System Drugs Advisory Committee (PCNS) on Monday, June 10, 2024, to discuss donanemab, which Eli Lilly and Company (NYSE: LLY) has submitted for the treatment of early symptomatic Alzheimer’s disease. The open public hearing portion of the meeting will be conducted virtually.

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Pharma Pulse 5/8/24: Navigating the Long, Bumpy Road to Rare Disease Diagnosis and Treatment, ‘Deepfake’ Detector to Disinformation & more

Pharmaceutical Commerce

The latest news for pharma industry insiders.

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Deal activity in pharma industry in April 2024

Express Pharma

In April 2024, the healthcare industry reported 96 deals worth $13.4 billion, compared to the last 12-month (April 2023 to March 2024) average of 94 deals worth $20 billion. Vertex Pharmaceuticals Inc, a biotechnology company, to acquire Alpine Immune Sciences Inc, a clinical stage biotechnology company, for a consideration of approximately $4.9 billion in cash; Ono Pharmaceutical, an immuno-oncology company to acquire Deciphera Pharmaceuticals Inc, a biopharmaceutical company focused on disco

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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FDA sets June adcomm date for Lilly’s Alzheimer’s drug

pharmaphorum

FDA advisors will meet on 10th June to discuss Eli Lilly's Alzheimer's candidate donanemab, shortly after casting an eye over Lykos' MDMA-based psychedelic for PTSD.

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Pioneering the next wave of LBP-based therapeutics

European Pharmaceutical Review

Although we have yet to understand the human microbiome and its role in disease fully, the scientific evidence on the efficacy of complex live biotherapeutic products (LBPs) in modulating the microbiome is striking, as evidenced by the approval of the first two commercial donor-derived products, Rebyota and VOWST, in 2022 and 2023, respectively. What are the top three trends in microbiome-based therapeutic development?

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Zenas’ $200m round heads big clutch of bio financings

pharmaphorum

Our round-up of biotech financings is headed by a $200m round for Zenas, with Cellectis, Reunion, Karius, Context, and Enlaza also raising nine-figure sums

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Hashimoto’s-Friendly Beauty Products

The Thyroid Pharmacist

I’ve been a girly girl for most of my life. From a young age, I loved dressing up in fancy outfits and carrying around a purse, and I would always find my way into my mom’s and aunt’s “treasures and jewelry”. When my family moved to the United States when I was nine, my proudest possession was my first real Barbie doll (they were hard to get in Poland), and I got my first “kid” make-up set at age ten — complete with pink lipstick and neon blue and purple eyeshadows!

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.