Tue.Oct 29, 2024

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STAT+: Dreams of cancer vaccines are becoming more real. Here are 9 scientists making it happen 

STAT

Vaccines are the original immunotherapy, in the view of Ryan Sullivan, a cancer immunotherapy researcher and oncologist at Mass General Cancer Center. But many other modes of immunotherapy for cancer were approved first — checkpoint blockade drugs like Keytruda and engineered immune cell therapies like Yescarta. Shadowed by the successes of other therapies, the field of cancer vaccines was “seemingly dying,” Sullivan said.

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How AZ’s respiratory wins are ramping up for a bigger prize in COPD

PharmaVoice

As AstraZeneca builds up indications for Fasenra, an ongoing trial will determine whether the respiratory drug can make up for past stumbles in COPD.

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STAT+: VCs move to launch U.S.-based companies to develop drugs developed in China

STAT

As Chinese biopharma companies rise on the international stage, they are increasingly finding VC partners — in the United States. U.S. companies have long signed licensing deals with Chinese drugmakers. But increasingly American venture capitalists are building U.S.-based companies from scratch to test and ultimately seek to commercialize innovative drugs developed in China.

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Informal referrals deprive pharmacies of 'more than £115m a year'

The Pharmacist

Informal referrals to community pharmacies deprive pharmacies of more than £115 million each year, Community Pharmacy England (CPE) has estimated. This is the amount that would have been paid if existing referral routes had been used appropriately by GPs and NHS 111, rather than patients being signposted informally to their local community pharmacy.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Opinion: Fecal transplants are saving lives — but are now at risk

STAT

Twenty years ago, a respected colleague asked me to perform a “poop transplant” on a local schoolteacher with multiply recurrent C. difficile infection.  I was incredulous and skeptical, but my colleague (a friend but a forceful one) persisted until I ultimately acquiesced.  Soon I was in a hazmat suit blenderizing stool and performing my first (subsequently named) fecal microbiota transplant, or FMT.

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Biogen refreshes its C-suite; Novartis writes down MorphoSys assets

BioPharma Dive

Daniel Quirk, an immunology and neuroscience executive at Bristol Myers Squibb, will be Biogen’s next chief medical officer, while Robin Kramer will replace retiring CFO Michael McDonnell.

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Upskilling and reskilling: Key to driving innovation in India’s pharma sector

Express Pharma

India’s pharmaceutical industry, the third largest globally by volume, plays a key role in improving global healthcare outcomes. The Covid-19 pandemic accelerated the digital transformation and underscored the importance of adaptability. In this evolving landscape, upskilling and reskilling have become essential as technological advancements, regulatory changes, and the demand for innovative healthcare solutions continue to grow.

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Opinion: I’m the director of the Center for Medicare. Here’s how we executed the first round of drug price negotiation

STAT

The historic Inflation Reduction Act of 2022 has fundamentally improved the affordability of and access to prescription drugs for millions of people with Medicare. The law laid out aggressive timelines for implementing the Medicare Drug Price Negotiation Program. As the director of Medicare, my team and I worked thoughtfully and diligently to stand up the program — on time and successfully.

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PHTI review of digital hypertension tools gives mixed results

pharmaphorum

An evaluation of digital health technologies for hypertension by the Peterson Health Technology Institute (PHTI) finds some provide a clinical benefit, while others are lacking.On the plus side, the health technology assessment (HTA) body has concluded that tools to help people manage their antihypertensive drug treatment can deliver benefits in reduced blood pressure.

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STAT+: Novartis raises profit guidance, pushes off myelofibrosis drug submission

STAT

LONDON — Novartis on Tuesday increased its earnings guidance for the third time this year, boosted by strong sales of its leading drugs.  The company said it anticipates full-year operating profit to grow by a percentage in the high teens, up from the previously forecasted mid- to high teens.  Separately, Novartis CEO Vas Narasimhan said it would be a “couple more years” before the company could submit to regulators an experimental drug for a rare bone marrow cance

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Why Every Small Business Needs an HCM Solution: A Comprehensive Guide

Managing HR tasks like payroll, compliance, and employee data can overwhelm small businesses. That’s where a Human Capital Management (HCM) solution comes in. Our eBook, Why Every Small Business Needs an HCM Solution: A Comprehensive Guide , shows how an HCM system automates tedious processes, ensuring your business stays compliant and efficient. You’ll learn how to simplify payroll, eliminate costly errors, and empower your employees with self-service tools.

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Joy as NICE lifts restrictions on myeloma drug Elrexfio

pharmaphorum

Patients in England and Wales with multiple myeloma are celebrating a decision by NICE to relax strict restrictions on eligibility to receive Pfizer's Elrexfio.In June, the cost-effectiveness agency cleared the use of the BCMAxCD3 bispecific antibody with 'optimised guidance' that allowed it to be used for a narrower range of patients than was covered by the approved label for the drug.

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STAT+: Pfizer beats earnings expectations in first report after criticism by activist investor

STAT

Pfizer released earnings Tuesday that handily beat analyst expectations in the company’s first quarterly report since an activist investor took a $1 billion stake in the drug giant and began putting pressure on its board and CEO. Pfizer reported adjusted earnings per share, a key metric watched by analysts at investment banks, of $1.06 per share compared to expectations of $0.60 per share among analysts surveyed by Visible Alpha.

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Cardiovascular benefits can increase Rybelsus’ competitiveness over other oral GLP-1RAs

Express Pharma

Novo Nordisk’s oral semaglutide, marketed as Rybelsus for type 2 diabetes, has not gained much presence in the GLP-1 receptor agonists (GLP-1RAs) market despite its approval in 2019, as its injectable alternatives prove to have higher efficacy and results both in diabetes and obesity patients. However, the market for oral GLP-1RAs is expanding, and Rybelsus’ latest results showed its benefits in reducing the risk in cardiovascular events in a specific patient population.

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STAT+: Eli Lilly says modified dosing of its Alzheimer’s drug may be safer

STAT

A change in the dosing regimen of Eli Lilly’s Alzheimer’s drug Kisunla resulted in a lower rate of brain swelling among patients in a clinical trial, new data reported Tuesday show. But it’s unclear whether the new dosing schedule, if approved by regulators, will convince doctors that the treatment is safer for patients. At 24 weeks of a Phase 3b trial, 24% of those taking the standard regimen experienced a side effect called ARIA-E, a kind of brain swelling.

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Best Practices to Streamline Compensation Management: A Foundation for Growth

Speaker: Joe Sharpe and James Carlson

Payroll optimization can be one of the most time-consuming and complex factors of small business management. Yet, organizations that crack the code on streamlining employee compensation often discover innovative avenues for growth. With the right strategies in place, outsourcing and streamlining payroll processes can result in substantial time and resource savings.

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MRP of 3 anti-cancer drugs to come down due to exemption from custom duty and reduction in GST

Express Pharma

In line with the Government’s commitment to ensure the availability of drugs at affordable prices, the National Pharmaceutical Pricing Authority (NPPA) has issued an Office Memorandum dated October 28, 2024, directing the concerned manufacturers to reduce the maximum retail price on three anti-cancer drugs, Trastuzumab, Osimertinib and Durvalumab. This is in pursuance to the announcement made in the Union Budget for the year 2024-25 exempting these three anti-cancer medicines from custom duty.

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Q&A: Why drafting new rules on ultra-processed foods is so hard

STAT

Ultra-processed foods are part of daily life, filling 60% to 70% of the American diet. That umbrella term covers a wide variety of packaged foods, from snacks carrying added sugar, salt, and saturated fat combined with preservatives for shelf life, additives for flavor, colorants for eye appeal, and chemicals like bisphenols in the packages themselves.

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Pharmacies must contact labetalol patients following manufacturing mix-up

The Pharmacist

Pharmacies must contact all patients dispensed a specific batch of the beta blocker labetalol that may contain the wrong medication, the Medicines and Healthcare Products Regulatory Agency (MHRA) has instructed. If batch traceability is not possible, all patients dispensed this product in the last six months must be contacted. In a class two medicines recall […] The post Pharmacies must contact labetalol patients following manufacturing mix-up appeared first on The Pharmacist.

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D.C. Diagnosis: Could RFK Jr. go ‘wild’ on health and medicine?

STAT

You’re reading the web edition of D.C. Diagnosis, STAT’s twice-weekly newsletter about the politics and policy of health and medicine.  Sign up here  to receive it in your inbox on Tuesdays and Thursdays. Hello and happy Tuesday, D.C. Diagnosis readers! We are one week from Election Day; I probably don’t need to remind you.

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Enhance Healthcare Efficiency With Top Payroll & HCM Services

Running a healthcare facility requires precision and care, not just for patients but also for your staff. Our guide, "A Buyer’s Guide to Payroll & HCM Services," helps healthcare providers choose the best provider. Efficient payroll management ensures timely, accurate payments, critical for maintaining staff morale and trust. Compliance support helps navigate complex healthcare regulations and avoid costly fines.

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PM Modi inaugurates Lyfius Pharma’s flagship Penicillin-G facility

Express Pharma

Lyfius Pharma announces the inauguration of its Pen- G manufacturing facility, at Kakinada, Andhra Pradesh. With an annual production capacity of 15,000 metric tonnes, the facility was virtually inaugurated by Prime Minister Narendra Modi in the presence of Jagat Prakash Nadda, Union Minister of Chemicals and Fertilizers, and Health and Family Welfare; Dr Mansukh Mandaviya, Union Minister of Labour and Employment, and Youth Affairs and Sports; Anupriya Patel, Union MoS Chemicals and Fertilizers,

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GSK acquires autoimmune drug candidate

STAT

This story first appeared in The Readout newsletter.  Sign up for The Readout  and receive STAT’s award-winning biotech news delivered straight to your inbox.  Good morning, it’s a busy earnings week this week. Let’s get straight into reports from Pfizer and Novartis this morning.

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Delhi High Court reinstates Injunction stopping sale of Zydus’ Sigrima

Express Pharma

The Division Bench of Delhi High Court, on October 16, 2024, reinstated the injunction preventing Zydus Lifesciences from manufacturing, selling, or marketing its breast cancer drug Sigrima, a biosimilar of Roche’s Pertuzumab (Perjeta). The decision, made in response to Roche’s appeal on October 16, 2024, reversed an earlier order from October 9, 2024.

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Q&A: Why drafting new rules on ultra-processed foods is so hard

STAT

Ultra-processed foods are part of daily life, filling 60% to 70% of the American diet. That umbrella term covers a wide variety of packaged foods, from snacks carrying added sugar, salt, and saturated fat combined with preservatives for shelf life, additives for flavor, colorants for eye appeal, and chemicals like bisphenols in the packages themselves.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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'More we could do' to collaborate across professions, House of Commons event hears

The Pharmacist

The barriers and opportunities involved in working collaboratively across different healthcare professions – including how pharmacists can work across the multidisciplinary team – have been explored during a House of Commons event. The event was hosted by Watford MP Matt Turmaine, sponsored by Dr Bharat Shah of Sigma Pharmaceuticals, and chaired by Professor Mahendra Patel, […] The post 'More we could do' to collaborate across professions, House of Commons event hears appeared fi

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Lassa fever, eviction lawyers, ultra-processed foods, and poop transplants

STAT

Get your daily dose of health and medicine every weekday with STAT’s free newsletter Morning Rounds.  Sign up here. Today’s First Opinion on poop transplants taught me a new word:  fulminant. According to Merriam-Webster, the adjective describes something that comes on “suddenly and with great severity.” Scroll all the way down for context.

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2024 PharmaVoice 100s: Rare Disease Warriors

PharmaVoice

Pharma pros driving drug development and access for patients with high unmet needs.

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STAT+: Amid divorce from Dana-Farber, Mass General Brigham touts its own cancer institute

STAT

More than a year has passed since Dana-Farber Cancer Institute  dumped Mass General Brigham for a rival hospital chain , but the state’s biggest health care system is making a push now to say when it comes to cancer care, MGB’s still got it. Beginning in 2028, Dana-Farber will end its long and nationally acclaimed adult oncology partnership with Brigham and Women’s Hospital.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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Pfizer rebuffs Starboard criticism as it raises forecasts

pharmaphorum

Pfizer CEO Albert Bourla hit back at activist investor Starboard Value, saying measures to reset the pharma group are already well in hand

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Aldevron’s Anu Codaty on passion, leadership, and innovation

Outsourcing Pharma

Anu Codaty, VP of global marketing and strategy at Aldevron, is blazing trails in biotech, inspired by a family legacy in medicine and driven to create life-changing therapies.

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AbbVie gets bigger in Alzheimer's R&D with Aliada takeover

pharmaphorum

AbbVie agrees a $1.4bn cash deal to acquire Aliada Therapeutics, adding another anti-amyloid antibody to its Alzheimer's pipeline.

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Unlocking the Full Potential of Your CDMO Partnership: Strategies for Success

Drug Patent Watch

In the rapidly evolving landscape of biotechnology and pharmaceutical development, contract development and manufacturing organizations (CDMOs) have become essential partners for companies seeking to bring innovative medicines to market. However, navigating the complexities of these partnerships can be daunting, especially for smaller biotech companies.

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EC approves AstraZeneca’s Fasenra for EGPA treatment

Pharmaceutical Technology

The EC has approved AstraZeneca's Fasenra as an add-on therapy for adults with relapsing or refractory EGPA.

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