January, 2024

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PharmaVoice’s Crystal Ball: What’s next in drug innovation and clinical trials

PharmaVoice

As advanced therapies and patient perspectives strengthen their foothold in R&D, pharma is poised to deliver impactful treatments in record time.

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Pharmacy First: Are the floodgates about to open?

The Pharmacist

EXCLUSIVE: With the launch of Pharmacy First in England just days away, an under-pressure community pharmacy sector is torn between welcoming the opportunity and wondering whether patient demand will exceed its capacity. From 31 January, the launch of the highly anticipated service will see patients able to access advice and treatment for seven common conditions […] The post Pharmacy First: Are the floodgates about to open?

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Pharma Horizons: Artificial Intelligence

European Pharmaceutical Review

The first in our inaugural Pharma Horizons report series is dedicated to exploring the latest advances in artificial intelligence (AI) and machine learning (ML) for drug development, pharmaceutical manufacturing and quality control. AI/ML is predicted to be the top technology investment for 60 percent of life sciences companies over the next two years, according to a recent survey 1 from the Pistoia Alliance.

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Some dementia patients might have reversible symptoms caused by cirrhosis, study says

STAT

The descent into dementia can feel like traversing a minefield, coming across new symptoms without the hope of a cure. But some dementia patients, even up to 10% of people diagnosed with the condition, might actually have undiagnosed liver disease and accompanying neurological problems, a new study in JAMA Open Network suggests. Most importantly, it’s possible their liver-related brain symptoms could be resolved with treatment.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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CAR-T for lupus: the ‘tip of the iceberg’ for cell therapy in autoimmune disease

BioPharma Dive

Since a landmark paper in 2022, drugmakers have begun nearly a dozen trials of cell therapies for lupus, with more set to start. Here’s why their efforts are worth watching.

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JPM: Four ways FDA is seeking to buoy gene therapy

pharmaphorum

Dr Peter Marks, director of the FDA Center for Biologics Evaluation and Research told a packed house in San Francisco for JPM that FDA wants to support gene therapies in 2024.

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More Trending

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Infant formula recalled over contamination fears

The Pharmacist

Two Reckitt infant formulas have been recalled over concerns that they are contaminated with the bacteria Cronobacter sakazakii. Batch ZL3F7D of Nutramigen LGG Stage 1 Hypoallergenic Formula 400g and batches ZL3FAA and ZL3FDM of Nutramigen LGG Stage 2 Hypoallergenic Formula 400g may have been contaminated with the bacteria, the Food Services Authority (FSA) has said. […] The post Infant formula recalled over contamination fears appeared first on The Pharmacist.

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‘Medicine is going personalised’: Moderna’s UK boss on the coming vaccine revolution

The Guardian - Pharmaceutical Industry

Darius Hughes was a key figure in Pfizer’s pioneering Covid vaccine drive. Now he has changed companies – and sees a big future for mRNA technology The man who launched Pfizer’s Covid-19 vaccine in the UK three years ago – when 90-year-old Margaret Keenan in Coventry became the first person in the world to receive one – is now overseeing the construction of a manufacturing and research centre in Oxfordshire for rival US jab maker Moderna.

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STAT+: Years after a polarizing approval, Biogen walks away from Aduhelm

STAT

Biogen is giving up its ownership of Aduhelm , the Alzheimer’s disease treatment whose 2021 approval led to scrutiny and outrage, turning the page on a tempestuous chapter in the company’s long history. Neurimmune, the Swiss company that invented Aduhelm, will regain full rights to the intravenous medicine, Biogen said Wednesday. Biogen will also terminate an ongoing clinical trial meant to prove the treatment’s benefits for patients in the early stages of Alzheimer’s

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10 clinical trials to watch in the first half of 2024

BioPharma Dive

A non-addictive pain pill faces its definitive test, while study results in ALS, a rare heart disease and lung cancer could have far-reaching implications.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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Why amplifying the patient voice is crucial to clinical trial success

pharmaphorum

Amplifying the patient voice is essential for the success of clinical trials. Learn why it is crucial for patient engagement, recruitment, and overall trial success, and how it can address challenges such as transportation and financial barriers.

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How Quantum Computing Will Impact Pharma in 2024: Q&A With Erik Huestis, Partner at Foley Hoag

PharmExec

Huestis discusses the ways that quantum simulation and quantum systems can be used in areas such as drug discovery and the creation and protection of intellectual property in the life sciences industry.

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PulmCrit hot take: VAP prophylaxis (PROPHY-VAP trial)

EMCrit Project

background: ANTHARTIC trial Prophylaxis against VAP (ventilator associated pneumonia) has is already supported by a few studies in the literature, perhaps most notably the ANTHARTIC trial. That was a multi-center RCT evaluating 48 hours of therapy with ampicillin-sulbactam for patients intubated following cardiac arrest. Antibiotic therapy reduced early-onset VAP, with a trend towards more ventilator-free […] EMCrit Project by Josh Farkas.

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AbbVie and Umoja to develop new CAR-T therapies for cancer

Pharmaceutical Technology

AbbVie and Umoja Biopharma partnered for the development of in-situ CAR-T cell therapy candidates for oncology targets.

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STAT+: Judge skeptical of arguments against Medicare drug price negotiation

STAT

WILMINGTON, Del. — Wednesday was the first time that a federal judge asked questions in-person of drug industry lawyers who are trying to stop Medicare from negotiating drug prices. It didn’t go well for them. AstraZeneca’s lawyers argued that Medicare’s new powers amount to a taking of their property rights without due process.

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A new startup from Feng Zhang and an ex-Illumina executive zeroes in on the epigenome

BioPharma Dive

Moonwalk Biosciences, the latest biotech cofounded by the gene editing scientist, joins other startups aiming to alter gene expression without changing DNA.

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Data-driven disease research harnessing the genome

pharmaphorum

Discover how the UK Biobank is leveraging technology and the power of genomics in data-driven disease research. Join the digital revolution in understanding and combating diseases using cutting-edge techniques and large-scale genomic data analysis.

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Statins Could Potentially Slow Deterioration of Cognitive Function for Those With Alzheimer Disease

Pharmacy Times

Due to the observational nature of the study, the study authors said they cannot determine causal relationships between statins and cognitive decline for patients with Alzheimer disease.

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EMCrit 366 – Should Delayed Sequence Intubation (DSI) become the Standard for Critical Care Intubations?

EMCrit Project

Should DSI become the new standard? EMCrit Project by Scott Weingart, MD FCCM.

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Opinion: The emergency room is where the United States’ social problems come home to roost

STAT

From “ Legacy ” by Uché Blackstock, M.D., published by Viking, an imprint of Penguin Publishing Group, a division of Penguin Random House, LLC. Copyright © 2024 by Uché Blackstock, M.D. In the U.S., access to health care has long depended on insurance and a person’s ability to pay, with patients of color making up a disproportionate number of the under- or uninsured, as I have seen firsthand.

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STAT+: Can Wegovy treat depression as well as obesity? New research looks to GLP-1 drugs for mental illnesses

STAT

Drugs like Ozempic and Wegovy — already game changers for diabetes and obesity — are being studied to treat an entirely different growing health problem: mental health illnesses, including depression and bipolar disorder. Early data and anecdotes suggest that this class of GLP-1 drugs could help patients feel less depressed and anxious.

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Scientists document first-ever transmitted Alzheimer’s cases, tied to no-longer-used medical procedure

STAT

LONDON — There was something odd about these Alzheimer’s cases. Part of it was the patients’ presentations: Some didn’t have the classic symptoms of the condition. But it was also that the patients were in their 40s and 50s, even their 30s, far younger than people who normally develop the disease. They didn’t even have the known genetic mutations that can set people on the course for such early-onset Alzheimer’s.

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Opinion: I’m an anesthesiologist. Kenneth Smith’s execution by nitrogen gas was far from ‘textbook’

STAT

On Thursday evening, the state of Alabama executed Kenneth Eugene Smith by nitrogen gas. Now, there are dueling narratives about what happened. Alabama claims it went perfectly, proving that nitrogen is a humane, effective alternative to lethal injection (which it previously tried, unsuccessfully, to use on Smith). It says that based on this experience, other states should follow its example.

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Opinion: Which country has the best health care? That’s the wrong question

STAT

I’ve spent my career studying how different health care systems work. People love to ask me which country has the best care — and are often disappointed when I don’t have an easy answer for them. Every health care model involves people doing their best to balance competing priorities in the face of limited resources. In other words, every system involves tradeoffs.

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STAT+: From a small town in Wales, a scientific sleuth has shaken Dana-Farber — and elevated the issue of research integrity

STAT

PONTYPRIDD, Wales — The blog post that has shaken the leadership of Boston’s Dana-Farber Cancer Institute, one of the world’s preeminent cancer research centers, was written some 3,000 miles away, in a bare-walled, sparsely decorated flat, save for a stack of statistics books and a collection of Rubik’s Cubes. It’s here that Sholto David, an unemployed scientist with a doctorate in cell and molecular biology, spends his time poring over research papers looking

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STAT+: Ultima Genomics launching high-end DNA sequencers that can read genome for $100

STAT

Ultima Genomics, an upstart some observers have called a “ dark horse ” in the world of DNA sequencing, will soon launch a line of high-power instruments that can read a human genome for as little as $100, the company’s leadership told STAT. The sequencer, dubbed the UG 100, is a $1.5 million machine that can read up to 20,000 human genomes a year.

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HPV vaccine study finds zero cases of cervical cancer among women vaccinated before age 14

STAT

A historic new study out of Scotland shows the real-world impact of vaccines against the human papillomavirus: The country has detected no cases of cervical cancer in women born between 1988-1996 who were fully vaccinated against HPV between the ages of 12 and 13. Many previous studies have shown that HPV vaccines are extremely effective in preventing cervical cancer.

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Merck CEO refused to testify in Senate because he’s not an expert in drug pricing, Bernie Sanders says

STAT

WASHINGTON — Sen. Bernie Sanders on Thursday jabbed the CEO of Merck for telling congressional staff that he didn’t have the expertise to testify at a Senate hearing on prescription drug prices because he’s a tax attorney. Sanders, who has threatened to subpoena the CEOs of Merck and Johnson & Johnson over their refusal to testify at a hearing on why drug prices are higher in the United States than other countries, told reporters the reasons the companies gave ranged fro

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Can the government ask social media sites to take down Covid misinformation? SCOTUS will weigh in

STAT

WASHINGTON — The Supreme Court will this March hear arguments centered on the government’s role in communicating — and sometimes censoring — pertinent public health information in the midst of a pandemic. At the core of the lawsuit is whether the federal government’s requests for social media and search giants like Google, Facebook, Twitter, and YouTube to moderate Covid-19 misinformation violated users’ First Amendment rights.

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Pricey sickle cell treatments raise daunting new challenges for Medicaid programs

STAT

Living with sickle cell disease has not been easy on Kourtney Cunningham. The genetic blood disorder typically causes her to experience three episodes of extreme pain each month and she can end up in the hospital at least twice a year due to these crises. Then there are blood transfusions every four weeks.

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New chronic Covid study offers insight into which immunocompromised patients are most at risk

STAT

You’ve heard of long Covid, a condition in which the acute infection subsides but troubling symptoms persist. Less well known is chronic Covid: The virus just doesn’t leave, sometimes staying in patients’ bodies long enough to mutate into new variants. This happens to people whose immune systems are compromised, whether through disease or treatment, leaving them vulnerable to infections that last weeks, months, or, in one known case, a year.

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Abortion funds run short of money as demand soars and donations fall

STAT

The head of the Abortion Fund of Ohio had a sinking feeling as she looked at its end-of-year finances last month. The fund had paid out $1.5 million in 2023 to help close to 4,400 patients get abortions — up from 1,175 the year before — and the pace wasn’t sustainable. If the fund didn’t take a pause for a few weeks, she feared it would run out of money and have to close for good.

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Why many more people are lining up for a flu shot than a Covid vaccine

STAT

America is over the Covid vaccine. Frantic lineups for scarce doses when Covid vaccines first became available have long since given way to widespread indifference. Each new round of boosters has drawn fewer bared arms than the round before it. The Centers for Disease Control and Prevention estimates that, as of Jan. 6, a mere 21.5% of Americans aged 18 and older and 11% of children have been vaccinated with the latest Covid vaccine.

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Rollout of a new malaria vaccine kicks off in Africa

STAT

LONDON — Starting Monday, a new, highly effective malaria vaccine will be rolled out for the first time, as an immunization campaign for children kicks off in Cameroon — a day that global health officials say marked a historic step in the decades-long quest to protect people from one of the world’s deadliest infections. The vaccine drive in Cameroon — the first launch of the vaccine outside of clinical trials and pilot programs — comes as some 20 African countr

Vaccines 364
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Opinion: The FDA and FTC need to crack down on TikTok and Instagram influencers pitching prescription drugs

STAT

In June, the Food and Drug Administration issued a warning letter about advertisements for the drug Recorlev for Cushing’s syndrome — its first in more than a year about webpages that make “false or misleading claims” about prescription drugs. More recently, in December the agency published guidance about TV and radio advertisements.

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