Pharmacy Joe

MAY 1, 2024

Subscribe on iTunes , Android , or Stitcher The label of “penicillin allergic” usually sticks to a patient’s medical record forever. A 50 y/o male with an SSTI had an unknown allergy to penicillin, received a single dose of ceftriaxone in the ED and was then switched to piperacillin-tazobactam as an inpatient.

Inpatient

Pharmacy Joe

OCTOBER 11, 2020

In this episode, I’ll discuss how to predict the pharmacotherapy needs of your patient and team during an inpatient medical emergency. This is when you do regular pharmacist things like drawing up and labeling medications, and calculating doses. This work is valuable because it frees a nurse up to be hands-on with a patient.

Inpatient

Pharmacy Joe

FEBRUARY 26, 2025

The study was an open-label, multicenter, randomized controlled trial in 9 Australian Emergency Departments. Secondary outcomes included serious adverse events. There were no differences in serious adverse events between groups either. This difference was not statistically significant.

Inpatient

Pharmacy Joe

NOVEMBER 12, 2023

Adverse event rates were similar between groups. Secondary outcome measures were numerically favorable for haloperidol including the need for open-label haloperidol or other antipsychotics, and self-extubation or invasive device removal. However none of these secondary outcomes reached statistical significance.

Hospitals

Pharmacy Joe

NOVEMBER 12, 2023

Adverse event rates were similar between groups. Secondary outcome measures were numerically favorable for haloperidol including the need for open-label haloperidol or other antipsychotics, and self-extubation or invasive device removal. However none of these secondary outcomes reached statistical significance.

Hospitals

Pharmacy Joe

APRIL 20, 2022

This was a multicenter, open-label, noninferiority randomized clinical trial of 206 ICU patients with VAP. No significant differences were found between groups in secondary outcomes such as ICU-free days, ventilator-free days, and adverse events.

Inpatient

Pharmacy Joe

AUGUST 21, 2022

Recently published in Lancet was a non-inferiority, open-label, multicentre, randomized trial that sought to clarify the safety of early antibiotic discontinuation in hematology patients with fever of unknown origin during chemotherapy-induced neutropenia.

Chemotherapy

Pharmacy Joe

OCTOBER 22, 2023

The ACORN randomized trial sought to compare rates of AKI and neurotoxicity in patients hospitalized with acute infection who were randomized 1:1 in an open-label fashion to receive either piperacillin-tazobactam or cefepime for gram-negative coverage. However, other studies have examined a link between increased neurotoxicity with cefepime.

Hospitals

Pharmacy Joe

OCTOBER 22, 2023

The ACORN randomized trial sought to compare rates of AKI and neurotoxicity in patients hospitalized with acute infection who were randomized 1:1 in an open-label fashion to receive either piperacillin-tazobactam or cefepime for gram-negative coverage. However, other studies have examined a link between increased neurotoxicity with cefepime.

Hospitals

Pharmacy Joe

NOVEMBER 29, 2020

To improve the data available in this patient population, investigators in Brazil completed a multicenter, randomized, open-label, noninferiority trial with 1000 patients comparing rivaroxaban with warfarin for patients with atrial fibrillation and a bioprosthetic mitral valve.

Inpatient

Pharmacy Joe

OCTOBER 3, 2021

A group of authors recently published in NEJM the results of a randomized, multicenter, open-label, parallel-group trial in the UK examining this issue. The authors also applied a time-to-event analysis in which data were censored at the time of discharge or at day 15. The most common cause for cirrhosis was alcohol.

Hospitals

Pharmacy Joe

AUGUST 21, 2022

Recently published in Lancet was a non-inferiority, open-label, multicentre, randomized trial that sought to clarify the safety of early antibiotic discontinuation in hematology patients with fever of unknown origin during chemotherapy-induced neutropenia.

Chemotherapy

RX Note

FEBRUARY 23, 2023

G6PD Deficiency - Explaining G6PD Deficiency Ramadan - Medications during Ramadan fasting Adverse Drug Reactions Adverse Drug Reactions - All adverse reactions are adverse drug event Pharmacovigilance - To detect unreported ADRs Drug Allergy - Management vary based on the signs and symptoms Medicine-induced Discolouration - Red?

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