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STAT+: Cogent Biosciences drug improves symptoms of chronic immune disorder, study results show

STAT

Cogent Biosciences said Monday that its experimental drug reduced the symptoms of a chronic immune disorder called indolent systemic mastocytosis. The results mean the drug achieved the goals of a Phase 3 study, but a comparison to a rival treatment from Blueprint Medicines remains muddled. 

Immunity 270
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CDC vaccine advisory committee to review long-approved immunizations

STAT

Martin Kulldorff, named co-chair of the Advisory Committee on Immunization Practices after health secretary Robert F. A leader of a federal vaccine advisory committee said Wednesday that the panel would start a review of long-approved vaccines, as well as the cumulative effect of the shots given to children and adolescents. Kennedy Jr.

Immunity 364
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Opinion: Six former CDC vaccine advisory committee chairs warn: U.S. risks losing access to life-saving immunizations

STAT

As former chairs of the CDC’s Advisory Committee on Immunization Practices ( ACIP ), we are deeply alarmed by the growing politicization of vaccines — a public health innovation that has saved 154 million lives globally. The damage, once done, may not be easily repaired. Read the rest…

Immunity 363
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STAT+: Vertex to buy Alpine Immune Sciences for $4.9 billion

STAT

Vertex Pharmaceuticals will buy Alpine Immune Sciences, a maker of protein-based medicines that harness the immune system, for $4.9 billion, the companies announced Wednesday. It is the largest acquisition in Vertex’s history.

Immunity 361
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Researchers identify ‘molecular switch’ in lupus that could stymie harmful immune response

STAT

But new research asks the question: What if immune cells could be turned back into good guys, and actually help save tissue damaged by autoimmune disease?    Lupus is complicated because it wields the body’s own defenses against itself, generating a continuous immune misfire.   Read the rest…

Immunity 361
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STAT+: Like a vampire, some cancer cells can suck the energy source from immune cells

STAT

As elite hunters of the immune system, T cells are constantly prowling our bodies for diseased cells to attack. New research shows that some cancer cells can fire a long nanotube projection into the T cell that, like a vampire’s fang, sucks energy-creating mitochondria from the immune cell, turning the predator into prey.

Immunity 363
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Smoking impairs immune response, even after quitting, new study says

STAT

The study , published Wednesday in Nature, underscores the importance of never lighting up that first cigarette, based on its conclusion that smoking has much longer harmful effects on immune responses than previously understood. Read the rest…

Immunity 363