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Cogent Biosciences said Monday that its experimental drug reduced the symptoms of a chronic immune disorder called indolent systemic mastocytosis. The results mean the drug achieved the goals of a Phase 3 study, but a comparison to a rival treatment from Blueprint Medicines remains muddled.
Martin Kulldorff, named co-chair of the Advisory Committee on Immunization Practices after health secretary Robert F. A leader of a federal vaccine advisory committee said Wednesday that the panel would start a review of long-approved vaccines, as well as the cumulative effect of the shots given to children and adolescents. Kennedy Jr.
As former chairs of the CDC’s Advisory Committee on Immunization Practices ( ACIP ), we are deeply alarmed by the growing politicization of vaccines — a public health innovation that has saved 154 million lives globally. The damage, once done, may not be easily repaired. Read the rest…
Vertex Pharmaceuticals will buy Alpine Immune Sciences, a maker of protein-based medicines that harness the immune system, for $4.9 billion, the companies announced Wednesday. It is the largest acquisition in Vertex’s history.
But new research asks the question: What if immune cells could be turned back into good guys, and actually help save tissue damaged by autoimmune disease? Lupus is complicated because it wields the body’s own defenses against itself, generating a continuous immune misfire. Read the rest…
As elite hunters of the immune system, T cells are constantly prowling our bodies for diseased cells to attack. New research shows that some cancer cells can fire a long nanotube projection into the T cell that, like a vampire’s fang, sucks energy-creating mitochondria from the immune cell, turning the predator into prey.
The study , published Wednesday in Nature, underscores the importance of never lighting up that first cigarette, based on its conclusion that smoking has much longer harmful effects on immune responses than previously understood. Read the rest…
The study, which estimated childhood vaccination coverage between 1980 and 2023 in 204 countries and territories, found that the Covid-19 pandemic significantly intensified existing immunization challenges. Read the rest…
Researchers studying the ways these systems change with age refer to them collectively as “immunosenescence,” or, more poetically, the “ twilight of immunity. ” But even as scientific understanding of the phenomenon has grown over the past decade, the forces driving it remain murky.
The ads, which tell parents to contact their general practitioners if they’ve missed getting their kids immunized, are designed to capture parents’ desires to keep kids safe. Read the rest…
“Although the appointees to [the Advisory Committee on Immunization Practices] have scientific credentials, many do not have significant experience studying microbiology, epidemiology or immunology. Kennedy Jr. to be delayed, citing their lack of experience and potential bias against some vaccines.
Moderna announced Monday that, in a Phase 3 clinical trial, its combination Covid-19 and influenza vaccine generated stronger immune responses in older adults than individual vaccines that target those viruses.
New research published Thursday in Science has identified proteins present in the blood of people with long Covid that could point the way to a much-needed diagnostic test and possibly to future therapeutic targets.
The evidence presented to the WHO team pointed to what’s sometimes called an immunity gap that was created by the pandemic. But a rapidly organized meeting Thursday between the World Health Organization and health officials in China assuaged much of that concern.
Immune checkpoint inhibitors, drugs that can help make the immune system recognize and destroy cancer more aggressively, are one of the most important medicines in cancer treatment today.
This “summer of discovery,” as McKenna called it, brought him back to the immune system. McKenna discussed possibilities with his teenagers and Prometheus’ chief scientific officer.
And while the meeting took place two days after a report that the department had tapped vaccine critic David Geier to conduct a study looking for a link between immunizations and autism, the Louisiana senator said that issue did not come up. Read the rest…
Right now, anyone with health insurance — adults and children alike — who wants a vaccine that is recommended by the Advisory Committee on Immunization Practices can get it for free. It could also take money out of Americans’ wallets.
That’s the premise behind Normunity, which launched Tuesday with $65 million from investors to develop a suite of drugs that it dubs “immune normalizers” to help restore the natural ability of the immune system’s T cells to infiltrate and destroy tumors.
The Food and Drug Administration on Friday authorized a new antibody to protect immunocompromised individuals against Covid-19. The drug, known as Pemgarda and marketed by the biotech Invivyd, is the first such drug to become available since the agency pulled AstraZeneca’s Evusheld off the market in January 2023.
Prior research has shown that people with obesity have deficiencies in their “natural killer” cells, or NK cells — immune cells that help in combating cancer. A new small study suggests they may also be useful in fighting cancer.
LONDON — In this case, it was neither the chicken nor the egg that came first. Rather, it started with some specially engineered cells in a lab. The chicken cells had had their genomes edited, not to correct a faulty mutation, but in an effort to blunt the bird flu virus.
Today, we see insulin-producing cells survive in a human body without triggering an immune rejection, and have some big news from CMS. Hope those of you who were in San Francisco for J.P. Morgan are resting, recovering, and not coping with any quad-emic strains. Read the rest…
The need-to-know this morning Nektar Therapeutics said its embattled immune drug rezpeg significantly improved skin clearance rates in patients with atopic dermatitis, achieving the goals of a Phase 2 study. The stock more than doubled in price in early trading.
Alison Buttenheim was floored by a sign she saw in her doctor’s office when she went to get the first jab of the two-dose shingles vaccine to protect her against painful flare-ups of varicella zoster. “Medicare patients cannot receive Tdap or zoster vaccines here. They need to obtain [them] at their pharmacy.
After dropping its neuroscience program earlier this year, the clinical-stage oncology company is doubling down on a candidate targeting the MAPK pathway.
Alison Sbrana was in the belly of an opera when her life changed. Down in the pit, surrounded by fellow orchestra members, she’d been straining to play her flute for half the show. As performers overhead enveloped the audience in arias, Sbrana felt like the Hulk was pulling on the tendons in the right side of her neck.
Pfizer and BioNTech said Friday that their combined mRNA vaccine candidate against influenza and Covid-19 showed a lower immune response against one type of influenza, influenza B, in a Phase 3 trial, a setback for the vaccine. ” Continue to STAT+ to read the full story…
This time around, we note that Immuneering hired Igor Matushansky as chief medical officer. Don’t be shy. Everyone wants to know who is coming and going. And here is our regular feature in which we highlight a different person each week.
This happens to people whose immune systems are compromised, whether through disease or treatment, leaving them vulnerable to infections that last weeks, months, or, in one known case, a year.
There’s symptom management, hopeful periods of remission often followed by relapses, but rarely a lasting fix for the way their immune system attacks healthy cells. If the immune system is an army, then those with conditions like lupus, multiple sclerosis, or rheumatoid arthritis are often fighting a never-ending war of friendly fire.
Rheumatology — the study of immune-system-driven diseases of the bones, joints, muscles, and in-betweens — has inherited plenty of hand-me-downs from cancer research. For example, there are ways of squelching an immune system in order to shrink certain kinds of cancerous tumors.
Keytruda is a cancer immunotherapy, which stimulates the immune system to attack tumor cells. For Merck, the new under-the-skin, or subcutaneous, formulation of Keytruda could represent a major way of holding on to a larger share of Keytruda’s $25 billion in annual sales than would otherwise occur when the medicine’s U.S.
The new members of the Advisory Committee on Immunization Practices include a psychiatrist who has studied the connection between pregnant women eating fish and autism, and a board member of an organization that raises alarms about vaccine safety.
Companies that are developing new medicines for autoimmune conditions, as well as other immune system disorders, have brought in more money and closed more deals so far this year than most other areas, including the cardiometabolic field, data from investment bank Oppenheimer show.
The Food and Drug Administration on Monday approved a Pfizer vaccine that aims to protect newborns against RSV by vaccinating pregnant people in the latter part of pregnancy. The vaccine, Abrysvo, has also been approved for use in adults 60 and older to protect them against respiratory syncytial virus. Read the rest…
Tolerance is the holy grail in calming autoimmune disease, a truce in the immune system’s faulty battle against the body’s own fabric. In type 1 diabetes, immune fighters attack beta cells in the pancreas that produce insulin, the hormone that controls glucose levels in the blood.
The charity, the Telethon Foundation, took ownership from a small biotech of a drug that has been approved in Europe to treat an ultra-rare immune disorder called ADA-SCID. Recently, though, it added an unusual new role — as a gene therapy company of sorts.
New research shows that certain bacteria can alter antibodies so much that they’re unrecognizable to the body’s defenses — potentially leading to immune friendly fire. The bacteria, called Akkermansia muciniphila, can strip the sugar coating from IgA antibodies, immune proteins abundant in the gut.
Agency officials previously said they would release ethics forms for seven new members of the Advisory Committee on Immunization Practices before the group’s first meeting in late June. That deadline came and went.
Dupixent is already a blockbuster therapy for a range of immune-mediated diseases, but the Food and Drug Administration’s approval of the drug for chronic obstructive pulmonary disease greatly expands its reach — and could give it an edge over rival treatments in development. There are 300,000 such people in the U.S.,
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