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STAT+: Cancer therapy’s new ‘gold rush’:  bispecific antibodies that hit key combination of targets

STAT

Immune checkpoint inhibitors, drugs that can help make the immune system recognize and destroy cancer more aggressively, are one of the most important medicines in cancer treatment today.

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Pandemic-related immunity gap in kids explains surge of respiratory infections in children in China, says WHO

STAT

The evidence presented to the WHO team pointed to what’s sometimes called an immunity gap that was created by the pandemic. But a rapidly organized meeting Thursday between the World Health Organization and health officials in China assuaged much of that concern.

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Could long Covid’s signs of immune dysregulation in the blood lead to a diagnostic test?

STAT

New research published Thursday in Science has identified proteins present in the blood of people with long Covid that could point the way to a much-needed diagnostic test and possibly to future therapeutic targets.

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RSV vaccines may be linked to small increased risk of developing Guillain-Barré syndrome, data suggest

STAT

At a meeting Thursday of the Advisory Committee on Immunization Practices, vaccine safety experts from the two agencies presented data that showed what appears to be an elevated rate of GBS, as the condition is called, among people who got the Pfizer vaccine, although there were also cases detected among people who got the GSK product.

Vaccines 359
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STAT+: ‘We’ve got a new target’: Bispecific antibody for multiple myeloma succeeds in mid-stage trial

STAT

NEW ORLEANS — Researchers had hoped in recent years that a protein called GPRC5D might offer a new way to get the immune system to hunt down and destroy multiple myeloma cells. Now, the results of a Phase 2 study on a bispecific antibody targeting this protein offers confirmation.

Immunity 314
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Tackling immune-mediated disease with CAR Tregs

European Pharmaceutical Review

Recognising the potential of CAR T cells to act as highly targeted therapeutics, several biotechnology companies – including Sangamo Therapeutics – have established development pipelines of CAR T regulatory cells (Tregs) that aim to tackle immune?mediated What are Tregs and how are they applicable to immune-mediated disease?

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STAT+: Cancer vaccines gain momentum, after years of disappointing results

STAT

But as researchers from different companies and academic institutions presented promising early data at the American Association for Cancer Research annual meeting in San Diego this week, experts said there’s a collective feeling of turning a corner. SAN DIEGO — Cancer vaccines have traveled a potholed road over the last decade.

Vaccines 364