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s CDC Vaccine Committee Overhaul for the Pharmaceutical Industry June 10, 2025 By Christopher Cole News Article The dismissal of all 17 members of the Advisory Committee on Immunization Practices has far-reaching impacts for the industry and beyond. ACIP plays a foundational role in shaping immunization policy in the US.
Suggestions for providers featured in the guidelines include determining if opioids should take place, selecting appropriate dosages, determining prescription length and follow-up, and assessing and reducing risks of misuse, overdose, and opioid use disorder.
Acalabrutinib plus bendamustine and rituximab may become new standard care for untreated MCL. Cancer Therapy Advisor. June 21, 2024. Accessed March 16, 2025.
The study aimed to evaluate both safety and preliminary efficacy outcomes, with a specific focus on hematologic toxicity, pharmacokinetics, and immune system effects. Flow cytometry data indicated no significant increases in immune checkpoint markers typically associated with T-cell exhaustion.
2 Len enhances immune response and promotes antibody-dependent cellular cytotoxicity, whereas R targets CD20-expressing B cells. 4,5 This multimodal immune engagement likely contributes to the response observed even in patients with low CD30 expression.
New labels will include study summaries, improved dosage warnings, and information on overdose reversal agents to enhance patient and healthcare professional awareness. The FDA mandates randomized clinical trials to assess long-term opioid use benefits and risks, ensuring timely and efficient completion.
Published June 27, 2025 Meagan Parrish Lead Editor post share post print email license Justin Sullivan via Getty Images Listen to the article 7 min This audio is auto-generated. Other PrEP regimens on the market require daily oral dosages or shots every few months, but the latest version is only administered twice a year.
SHOW MORE Administering influenza, COVID-19, and RSV immunizations at the same time may improve vaccine uptake. Pediatric vaccination laws vary, but pharmacists play a crucial role in educating families about vaccines like MMR, Tdap, and HPV. Before autumn approaches, start thinking about respiratory vaccines.
Animal studies reveal dose-dependent hepatic responses to CBD, supporting the need for cautious monitoring even at consumer-relevant dosages. Clinical trials show low-dose CBD can cause significant liver enzyme elevations in 5.6% of healthy adults, necessitating liver function monitoring.
HOPA has selected 4.0 CE hours from BCOP Updates 2024 and the Annual Conference 2025, featuring topics such as acute leukemia, cellular therapy for solid tumors, and the pharmacist’s role in serious illness conversations. Additional information is available here. Subscribe Now!
Additionally, ANDA submissions should extrapolate the RLD safety and effectiveness data for drugs with the same active ingredients, dosage forms, strengths, routes, and labeling. In the 505(j) ANDA approval pathway, on the other hand, submissions can be multisource generic drugs; however, this pathway requires bioequivalence to the RLD.
Generics are exact chemical copies of small-molecule drugs, with identical active ingredients, strengths, dosage forms, and routes of administration. Although generics and biosimilars offer lower-cost alternatives to brand-name drugs, they are not the same. JAMA Health Forum. 2024;5(3):e235429. doi:10.1001/jamahealthforum.2023.5429
Both Hadlima and Hyrimoz share the same strengths and dosages and have no clinically meaningful differences from Humira when relieving patient symptoms. The most common reason for exclusion was the patient opting out of clinical follow-up with the specialty pharmacy team.
2 Guiding prescribers and patients through initiation of lumatperone, adjusting dosage amounts, and switching from other antipsychotics, emphasizing its favorable relapse reduction profile is key in preventing relapse.
HME in drug manufacturing typically employs corotated twin extruders and uses heat and pressure to create solid dosage forms, dispersing the active pharmaceutical ingredient within a molten polymer matrix, and forming a solid solution or amorphous solid dispersion. trillion economic impact in 2020. trillion economic impact in 2020.
Side effects can interfere with daily life, reduce quality of life, and even cause patients to reduce the dosage or discontinue the drug completely.¹ Up to 87% of individuals who take opioids for a long period time say they have OIC.
By incorporating a patient's genetic profile into therapeutic decision-making, pharmacists can identify optimal drug choices and dosages while minimizing the risk of adverse events (AEs). Developed in partnership with InterSystems, the platform uses proprietary algorithms to personalize drug selection and dosage.
A group of experts will present an encore abstract titled " Prevalence of Dosage Modifications and Impact on Response Milestone Among Patients With CML Treated With Imatinib Using Real-World Data " at the 2025 Oncology Pharmacists Connect (OPC) meeting in Austin, Texas, from June 19 to 20.
Challener News Article Pharmaceutical Technology Pharmaceutical Technology June 2025 Volume 49 Issue 5 Unique surface properties and ligand functionalization provide real advantages. The improved targeting capability of nanoscale delivery systems also leads to improved activation of immune cells in cancer vaccines.
link] The views expressed in this article are the authors' own and do not reflect the views of their employer. LinkedIn Workplace Learning Report 2024. LinkedIn Learning. Accessed May 15, 2025.
Despite observational evidence, causation is not established, necessitating further research on dosage effects and neurocognitive outcomes. The inconsistency underscores the need for further research, particularly prospective studies that control for dosage and assess neurocognitive outcomes over time.
1 "[Meloxicam injection] demonstrates our commitment to improving patient care by providing an alternate dosage form for pain management," Ron Scarboro, chief executive officer at Azurity Pharmaceuticals, said in a press release.
link] Short L, Holt RA, Cullis PR, Evgin L. Direct in vivo CAR T cell engineering. Trends Pharmacol Sci. 2024;45(5):406-418. doi:10.1016/j.tips.2024.03.004 Trends Pharmacol Sci. 2024;45(5):406-418. doi:10.1016/j.tips.2024.03.004
As of now, supply for this coming season matches last year’s total dosage, with production expected to continue. Backed by more than 40 real-world studies involving 250,000 immunized infants, Beyfortus has consistently proven itself as an effective RSV immunization,” said Thomas Triomphe, Sanofi’se xecutive vice president of vaccines. “To
Limitations included open-label design and dosage constraints, but the multicountry approach enhanced generalizability and external validity. All patients underwent a 20-week correction period for dosage titration and Hb correction, which was followed by an 8-week evaluation for efficacy assessments.
2 Vitamin D Immunity Vitamin D is a crucial hormone that supports bone health by facilitating the absorption of calcium and phosphorus, which is obtained mainly from sunlight exposure and food. Vitamin D is an accessible and inexpensive option compared to other drugs used to improve the response to chemotherapy.”
Selection of an appropriate OTC analgesic should take into consideration various patient factors, including the patient’s overall health status, current medical conditions, and medication profile, as well as patient preferences, which are often influenced by dosage form, required dosing intervals, and cost of OTC medication. December 2018.
3 Vitamin D and Immune Modulation in RA Immune system control and skeletal health are both significantly impacted by vitamin D. Pharmacists can play a pivotal role in guiding safe, evidence-based supplementation by recommending appropriate dosages, monitoring for interactions, and reinforcing adherence.
Steqeyma provides a new dosage form and strength, enhancing treatment flexibility for young patients with chronic inflammatory conditions. 2,3 Steqeyma, which was formerly known as CT-P43, is a human IL-12 and IL-23 antagonist indicated for multiple immune-mediated diseases.
2,3 LIMBER is a phase 1, open-label, dose escalation study evaluating INCB057643 as a monotherapy at a dose escalation of 4 to 12 mg daily (part 1) or in combination with ruxolitinib at a dosage of 4 mg once daily and escalating to the maximum tolerated dose in part 1 (part 2).
The investigators assessed a total of 90 patients who received talquetamab at a dosage of 0.8 mg/kg once every 2 weeks plus teclistamab at a dosage of 3.0 2 As a combination therapy, talquetamab and teclistamab show significant promise in the phase 1b/2 dose escalation and expansion in the RedirecTT-1 trial (NCT04586426).
HOPA has selected 4.0 CE hours from BCOP Updates 2024 and the Annual Conference 2025, featuring topics such as acute leukemia, cellular therapy for solid tumors, and the pharmacist’s role in serious illness conversations. Additional information is available here.
These are available in different dosages and forms, including lozenges, liquids, and sprays. The symptoms must be managed for MJ’s comfort and because, if left untreated, there is a higher risk of cavities, demineralization of teeth, sensitivity, or oral infections. Accessed July 16, 2025.
Even as I write this article, there is a breaking story of another round of such letters. All of this is in the face of yet another round of manufacturer cease-and-desist letters to compounding pharmacies and even physician offices demanding they cease all compounding, dispensing, and sale of compounded GLP-1s.
Some companies are combining mRNA vaccines with programmed cell death protein 1 (PD-1) inhibitors to activate the immune system and elicit tumour-specific T-cell responses. The LNPs provide targeted delivery of the mRNA directly to tumours, resulting in strong immune activation, tumour elimination, and durable immunological responses.
in Innovation Contest for Hematologic Malignancy Treatments June 26, 2025 By Patrick Lavery News Article The company’s mocravimod, a novel oral S1P receptor, is being evaluated for its efficacy as an addition to CAR-T cell therapies. million (approximately US$1.99 million (approximately US$1.99 million (approximately US$1.99
I was also surprised to learn about the many challenges that can occur with breastfeeding, such as latching issues, milk production issues, mastitis, and many others (that we’ll cover in this article). So I decided to put some resources together focused on thyroid-safe breastfeeding, and that is the focus of this article.
HOPA has selected 4.0 CE hours from BCOP Updates 2024 and the Annual Conference 2025, featuring topics such as acute leukemia, cellular therapy for solid tumors, and the pharmacist’s role in serious illness conversations. Additional information is available here.
DOSAGE AND ADMINISTRATION The recommended dose of gepotidacin is 1500 mg orally twice daily for 5 days. link] Download Issue PDF Download RIS Articles in this issue Blujepa From GSK Educate Patients About Safe Medication Disposal Pharmacist Spotlight: Callie Paine, PharmD Is There a Marketplace for Mail Order? News release.
In this article, you will learn: What low dose naltrexone, or LDN, is How LDN benefits Hashimoto’s Potential side effects The Root Cause approach vs. conventional treatment Where to find LDN and how to take it What Is LDN? 1] This is important for autoimmunity because the increased endorphins help to modulate and regulate the immune system.
In this article, you’ll learn more about: Why we have nutrient deficiencies. For more in-depth information, I encourage you to read these linked articles about each nutrient. However, in this article, I offer a brief overview of each, along with recommended products and dosages. Iron/ Ferritin (the iron storage protein).
My sweet son didn’t sleep through the night until he was almost three (and inspired my deep dive research into how to resolve sleep issues, which I shared in my article Sleep Solutions for Hashimoto’s ). Thus, my articles are focused on giving you real solutions, without having to consult with me. Boy, was I wrong!
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