Remove Chemotherapy Remove Compounding Remove Drug Development
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STAT+: Pharmacists can make shortage drugs, but at what cost?

STAT

Pharmacists increasingly are being asked to make drugs in bulk for hospitals that are in short supply, and they’re even beginning to make chemotherapies. Hospitals’ reliance on pharmacist-made drugs, a practice called compounding, has risen in step with worsening drug shortages.

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Antibody-drug conjugates gain traction in China oncology market: GlobalData

Express Pharma

The diagnosed prevalent cases of gastric, breast, and bladder cancers in China are expected to increase at a compound annual growth rate (CAGR) of 2.6 These companies have active research and development collaborations with various local players worldwide. per cent, 1.6 per cent, and 3 per cent, respectively, between 2022 and 2028.

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Novartis’ Pluvicto presents survival benefit for castration-resistant prostate cancer

pharmaphorum

Pluvicto becomes the first PSMA-targeted intravenous radioligand therapy – combining a targeting compound or ligand with a therapeutic radionuclide or radioactive particle (in this case, lutetium-177) – to demonstrate clinical benefit in mCRPC patients before receiving taxane-based chemotherapy.

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ACD-440 by AlzeCure Pharma for Neuropathic Pain (Neuralgia): Likelihood of Approval

Pharmaceutical Technology

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

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There is a large pipeline of CAR-T cell therapies for diffuse large B-cell lymphoma

Pharmaceutical Technology

By 2028, the market is expected to reach $25 billion, with a compound annual growth rate (CAGR) of 46.6%. The standard first-line treatment for DLBCL is a chemotherapy regimen, alongside the monoclonal antibody rituximab. There are a total of 124 companies involved in CAR-T cell drug development for this indication.

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PROTAC development gains momentum, but clinical performance is poor

Pharmaceutical Technology

This makes early R&D less risky, as many lead compounds are discontinued due to inadequate pharmacokinetic profiles and require excessively high dosages to be pharmaceutically active. Faslodex will be administered in the control arm of the Phase III study, allowing for direct comparison between the two ER degraders.

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Novel oral chemotherapeutic holds potential for stomach cancer patients

European Pharmaceutical Review

The availability of oral chemotherapy treatments would provide stomach cancer patients with the option of more efficacious drugs with improved tolerability in a more convenient dosage format” The poor clinical outcomes of stomach cancer make it a key target for drug development. New hope for stomach cancer patients.