Pharmaceutical Technology

JUNE 15, 2023

AI for drug development is rapidly streamlining R&D processes, speeding up time to market and providing a better experience for patients and providers. Learn more about the role of AI in drug development and how healthcare researchers are using it to shake up the field.

Drug Development 52

Drug Development Compounding 52

STAT

OCTOBER 20, 2023

Hospitals’ reliance on pharmacist-made drugs, a practice called compounding, has risen in step with worsening drug shortages. When the American Society of Health-System Pharmacists surveyed its members this past summer, 59% said they increased purchases from compounders because of drug shortages.

Compounding 268

Compounding Chemotherapy Hospitals Drug Development 268

STAT

APRIL 25, 2024

Now Baker is pushing forward in a different area of drug discovery research. A few years ago, his lab surprised scientists by constructing an AI-powered protein-folding prediction system rivaling Google’s DeepMind AlphaFold.

Compounding 329

Compounding Drug Development 329

Pharmaceutical Technology

JUNE 15, 2023

Drug development is already a difficult endeavor, with the vast majority of R&D efforts failing to produce a market-worthy product. Even reaching the clinical trial phase offers no guarantees, as only 12% of such drugs receive U.S. While this process is essential, it’s also slow, expensive and unpredictable.

Drug Development 52

Drug Development Compounding Adverse Reactions Dosage 52

STAT

APRIL 2, 2024

The autoimmune drug, brepocitinib, is being steered by a company called Priovant Therapeutics, which was formed as part of a deal between Roivant and Pfizer in 2021.     It is one of the most-watched compounds in Roivant’s pipeline for multiple autoimmune indications. Continue to STAT+ to read the full story…

Compounding 247

Compounding Drug Development 247

PharmaTech

MARCH 21, 2023

Thousands of drug candidates are abandoned annually due to solubility and bioavailability issues, but advanced formulation technologies can profoundly impact how a drug compound is processed in the body and improve the fate of many of these candidates, improving pharmacokinetic profiles and pharmacodynamic responses.

Drug Development 40

Drug Development Compounding 40

Pharmaceutical Technology

NOVEMBER 3, 2022

The funding will be used for the Phase III clinical trial and potential marketing of the investigational compound, ecopipam, for treating Tourette syndrome patients. The Food and Drug Administration granted Orphan Drug and Fast Track designation for ecopipam to treat Tourette syndrome.

Drug Development 52

Drug Development Compounding 52

STAT

FEBRUARY 26, 2024

A new update of the STAT Obesity Drug Tracker shows that at least 23 — about one-fifth — of the 105 obesity treatments in development or on the market are also being investigated for metabolic dysfunction-associated steatohepatitis, the fatty liver disease known as MASH (and previously called NASH ).

Diabetes 320

Diabetes Compounding Drug Development 320

STAT

OCTOBER 24, 2023

The conference opened to the news that Merck had signed one of the biggest licensing deals in industry history — worth up to $22 billion — to partner on three of the compounds from ADC specialist Daiichi Sankyo. GSK followed up with an ADC licensing announcement of its own (if a much smaller one).

Compounding 314

Compounding Drug Development 314

pharmaphorum

NOVEMBER 12, 2020

The company was founded as a spin-off of the University of Bern and Swiss research institute NCCR TransCure in April 2019, and is focused on the development of a new class of drugs that work on endocannabinoids, a type of neurotransmitter that bind to the receptors in the brain targeted by cannabinoid compounds.

Drug Development 79

Drug Development Compounding 79

Syner-G

SEPTEMBER 15, 2023

This shift from a linear to a network approach enhances the potential for one drug to target multiple sites. Structure-based drug design has evolved, facilitating the exploration of novel chemical probes and lead compound potency, and molecular docking utilizes target structures to predict interactions and offers simplicity and speed.

Drug Development 59

Drug Development Documentation Process Improvement Compounding 59

Express Pharma

DECEMBER 12, 2023

The collaboration is poised to help reshape the landscape of drug development and improve the way new therapeutic compounds are identified and optimised, says GlobalData. Sanofi’s strategic investment in Aqemia aligns with the industry’s growing recognition of AI’s potential to accelerate and enhance drug discovery processes.

Drug Development 93

Drug Development Compounding 93

Pharmaceutical Technology

OCTOBER 20, 2022

According to preclinical research, PIC compounds modulate protein translation but do not hinder the process. The post PIC raises funds through Series A for breast cancer drug development appeared first on Pharmaceutical Technology.

Drug Development 52

Drug Development Compounding 52

European Pharmaceutical Review

OCTOBER 9, 2022

Research published in the journal Nature Chemistry , shows how researchers from Stanford University in the US uncovered a promising new method to synthetically manufacture the compound tigilanol tiglate, named EBC-46, which could offer targeted medicine for cancer and other diseases.

Compounding 132

Compounding Drug Development 132

European Pharmaceutical Review

DECEMBER 13, 2022

North American psychedelic drug developers Mindset, PharmAla, Mydecine and Psyence have signed with clinical research organisation (CRO) Clerkenwell Health to trial therapies for mental health conditions, in London, UK, to benefit from the country’s swift drug regulatory process.

Compounding 100

Compounding Drug Development 100

PharmaTech

APRIL 11, 2023

Catalent offers end-to-end solutions to accelerate drug development and market entry, with specialization in handling highly potent, hormonal, and cytotoxic compounds, integrating comprehensive risk assessment and controls for management and containment.

Compounding 52

Compounding Drug Development 52

RX Note

JULY 8, 2023

Introduction Drug development is an expensive and lengthy process , taking about 2-3 billion dollars and over 10 years to discover and develop a drug to commercialization. Drug Development Timeline Discovery and Development Research for a new drug begins in the laboratory.

Drug Development 52

Drug Development Compounding 52

Pharmaceutical Technology

MAY 31, 2023

The university and Pharos have drawn up a memorandum of understanding (MoU) to use AI technology to identify potential compounds for the rapid development of treatments. The MoU allows Pharos to collaborate with the university’s researchers and gives access to its advanced drug discovery infrastructure.

Compounding 59

Compounding Data Entry Drug Development Pharmaceutical Companies 59

Express Pharma

FEBRUARY 5, 2024

Merck has recently agreed to acquire cancer drug developer Harpoon Therapeutics for about $680 million. The deal includes the novel HPN-217 and HPN-328 compounds, which are currently undergoing Phase II clinical trials for various malignancies.

Compounding 98

Compounding Drug Development 98

European Pharmaceutical Review

JULY 13, 2023

3 With established drug development pathways, we are accustomed to a rigid structure of translation from bench to bedside. While this is essential in the interrogation of novel compounds for which we know very little about their efficacy and safety, it is also true that some biomedical research is highly wasteful.

Compounding 87

Compounding Drug Development Clinical Pharmacology Documentation 87

European Pharmaceutical Review

DECEMBER 21, 2022

What sponsors should know about psychedelic drug development. Although some psychedelics have a long history in traditional medicine, regulatory agencies must evaluate psychedelic compounds the same way they assess any other drug. Psychedelic compounds are assessed by regulators the same way as any other drug.

Compounding 109

Compounding Controlled Substances Drug Development 109

PharmaTech

JANUARY 4, 2024

In the drug development process, drugs undergo a rigorous journey from target identification to new chemical entity identification, involving the screening of tens of thousands to potentially hundreds of thousands of compounds.

Compounding 40

Compounding Drug Development 40

European Pharmaceutical Review

JULY 24, 2023

A paper published in Pharmaceutics has proposed how a personalised preparation quality assurance programme can achieve this when these products are developed in compounding laboratories. PACMI selects a drug on a quarterly basis. It requests that compounding laboratories adhering to the programme send samples of it.

Compounding 69

Compounding Documentation Drug Development 69

European Pharmaceutical Review

FEBRUARY 27, 2023

Due to more biopharmaceutics classification system (BCS) II and BCS IV molecules being evaluated in early development, a market report has signalled that the bioavailability enhancement market will grow at a steady rate between 2022 to 2035.

Compounding 84

Compounding Drug Development 84

pharmaphorum

MAY 4, 2022

Testing drug compounds on a chip designed to mimic human organs sounds closer to science fiction than reality, yet the technology already exists and is already being put to use. The limits of animal models in drug discovery are well known.

Compounding 140

Compounding Drug Development 140

European Pharmaceutical Review

JULY 25, 2023

A compound annual growth rate (CAGR) growth of 5.9 Complex compounds offer targeted, effective medicines and typically outperform small molecule APIs. Disease areas Development of APIs for niche sectors such as rare or uncommon diseases offers new markets and can give small molecule API companies “an edge”, stated the report.

Compounding 79

Compounding Generic Medicine Drug Development Diabetes 79

European Pharmaceutical Review

JUNE 28, 2023

million by 2030, growing at a compound annual growth rate (CAGR) of 5.57 Growth of the pharmaceutical and biotechnology industries, plus the need for accurate and precise analytical tools in drug development and quality control are influencing factors. percent from 2023 to 2030. What is driving the HPLC market?

Compounding 82

Compounding Drug Development 82

European Pharmaceutical Review

NOVEMBER 6, 2023

million in 2023, with a predicted compound annual growth rate (CAGR) of 4.1 Demand for cell lines “in drug development , vaccine production, and therapeutic research is surging”, setting the market up for significant expansion, Ghosh noted. Total cell line product sales are expected to reach $3,124.4

Biosimilars 88

Biosimilars Compounding Vaccines Drug Development 88

Pharmaceutical Technology

MARCH 20, 2023

Predictive Oncology and Cancer Research Horizons, a part of Cancer Research UK (CRUK), has collaborated to drive cancer drug development using the former’s PEDAL platform.

Compounding 52

Compounding Drug Development 52

pharmaphorum

JUNE 30, 2022

Digital technologies are already helping to enable target identification, lead discovery, preclinical development, and clinical development, said Merck. The hope is that by using AI and ML capabilities, the currently unpredictable process of drug development can become much more predictable, and as a result less expensive.

Research Laboratories 107

Research Laboratories Drug Development Compounding 107

European Pharmaceutical Review

DECEMBER 16, 2022

According to a report by Future Market Insights (FMI), the global Alzheimer’s therapeutics market is expected to grow at a compound annual growth rate (CAGR) of 9.3 FMI stated drug manufacturers have been unable to validate the significant clinical benefits of treatment for numerous new compounds due to strict regulations.

Compounding 83

Compounding Immunity Immunization Drug Development 83

European Pharmaceutical Review

MARCH 2, 2023

A Gastrointestinal Simulator (GIS) was found to be superior to the traditional United States Pharmacopoeia (USP) method in predicting in vivo performance of Biopharmaceutics Classification System (BCS) Class IIa compounds. Katona et al.

Compounding 82

Compounding Drug Development 82

pharmaphorum

MARCH 24, 2022

GlaxoSmithKline has thrown its financial and drug development weight behind LifeMine Therapeutics, a US startup that aims to find new therapeutics from fungi – widely regarded as an underexplored resource of biologically-active compounds.

Compounding 88

Compounding Immunity Immunization Drug Development 88

Pharmaceutical Technology

NOVEMBER 9, 2022

Under the partnership, Unravel Biosciences will leverage its artificial intelligence (AI) gene network-based computational model for predicting the therapeutic compounds and underlying new targets depending on the transcriptomic information.

Compounding 52

Compounding Drug Development 52

pharmaphorum

JULY 21, 2021

The winning team relied on “handcrafted” features that incorporated their own insights into drug development timelines and which data entries should be discarded, according to MIT. The results were interesting, but the team wanted to do better. .

Data Entry 104

Data Entry Drug Development Compounding 104

PharmaShots

FEBRUARY 2, 2023

By using Endevica's technology platform, peptides can be altered to modify the activity of GPCRs behind the blood-brain barrier The collaboration helps to advance Endevica’s development of GPCR-targeting therapies on receptor sets to its lead compound.

Compounding 40

Compounding Drug Development 40

European Pharmaceutical Review

AUGUST 7, 2023

Many compounds can be synthesised by continuous-flow manufacturing, commented Ishitani. “By By adopting this method, we believe that we can contribute to a stable drug supply, respond to rare diseases and disasters, and aid new drug development.”

Compounding 77

Compounding Hospitals Drug Development 77