Sat.Mar 16, 2024 - Fri.Mar 22, 2024

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FDA authorizes new drug to protect immune compromised from Covid-19

STAT

The Food and Drug Administration on Friday authorized a new antibody to protect immunocompromised individuals against Covid-19.  The drug, known as Pemgarda and marketed by the biotech Invivyd, is the first such drug to become available since the agency pulled AstraZeneca’s Evusheld off the market in January 2023. New Omicron variants had rendered Evusheld ineffective.

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SAEM Clinical Images Series: Purple Finger

ALiEM - Pharm Pearls

A 30-year-old female with a past medical history of Crohn’s Disease presented to the ED for evaluation of an acutely bruised right 4th finger. She stated she was typing on a computer keyboard approximately 10 minutes prior to presentation and she noticed a sudden popping sensation at the base of her right ring finger. After the popping sensation, she noticed a cool sensation of the finger and numbness to the entire finger.

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An ocean of answers in a single cell — how proteomics can lead to better drugs

PharmaVoice

New tools that allow researchers to separate single cells can help map the complex web of proteins that lead to disease, providing new targets for biopharma.

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Pharmacist in practice: working with community nurses to support heart failure patients

The Pharmacist

Senior clinical pharmacist Brendon Jiang is vice-chair of the Royal Pharmaceutical Society (RPS) English Pharmacy Board and leads North Oxfordshire Rural Alliance (NORA) primary care network (PCN), a large team of eight pharmacy staff working across the Cotswolds. Here he tells The Pharmacist how PCN pharmacists are working with community heart failure nurses to upskill, […] The post Pharmacist in practice: working with community nurses to support heart failure patients appeared first on T

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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STAT+: Gene-edited pig kidney transplanted into a living patient for the first time

STAT

In a new test of xenotransplantation, a medical team at Massachusetts General Hospital announced Thursday that, for the first time, it had transplanted a kidney from a CRISPR gene-edited pig into a living patient. Surgeons performed the milestone procedure over four hours on Saturday, March 16, without complications. As of Thursday morning, the organ recipient, a 62-year-old man named Richard Slayman, was “recovering well” and expected to be discharged soon, the hospital said in a

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SAEM Clinical Images Series: Seeing Double

ALiEM - Pharm Pearls

A 53-year-old woman with no significant past medical history presented to the emergency department with a 3-day history of double vision on leftward gaze. She initially presented to urgent care with a chief complaint of chest heaviness and concern that her blood pressure was too high, but was sent to the emergency department for further cardiac and neurological evaluation after her urgent care provider noticed abnormal eye movement.

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Pharmacy closures 'could double' without action, contractors warn

The Pharmacist

Pharmacy closures are a 'worry' for patients and could 'double' if action is not taken to prevent them, community pharmacy representatives have said as they gathered outside the Houses of Parliament yesterday before meeting with MPs. Complete with a giant map to illustrate the scale of the closures in regions across England, the event marked […] The post Pharmacy closures 'could double' without action, contractors warn appeared first on The Pharmacist.

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STAT+: New gene therapy, to be priced at $4.25 million, has already transformed children’s lives

STAT

Every morning, Victoria Rasberry gets up before 6 a.m., walks to the bedroom down the hall, and helps her 8-year-old daughter Addi slide into a set of contraptions that squeeze and suck out the thick mucus constantly threatening to choke her airways closed. She feeds Addi breakfast through a stomach tube and makes sure she has the right mix of the 28 different medications required to keep her free of pain, infections, and seizures.

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AI in Drug Discovery: Day One

pharmaphorum

There is no denying that artificial intelligence (AI) has captured the imagination of innovators working across the pharmaceutical sector. The drug discovery space is no different, with myriad applications promising to revolutionise the way that researchers and sponsors approach identifying and progressing new drug candidates.

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FDA clears first-of-its-kind Duchenne drug for broad use

BioPharma Dive

The approval of Italfarmaco’s Duvyzat is the first for an oral, non-steroidal Duchenne drug and was issued for all patients at least six years of age, regardless of their genetic underpinnings.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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Guest Blog: Kidney Month Marks 31 Days of Action to Equip and Empower People to Prioritize their Kidney Health and Fight Kidney Disease

Putting Patients First Blog

Guest Blog: Kidney Month Marks 31 Days of Action to Equip and Empower People to Prioritize their Kidney Health and Fight Kidney Disease March 18, 2024 LaVarne A. Burton, President and CEO, American Kidney Fund March is Kidney Month , a month in which the American Kidney Fund (AKF) marks 31 days of action that are focused on equipping and empowering people with the tools and knowledge they need to prioritize their kidney health and fight kidney disease.

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Top U.S. addiction researcher calls GLP-1 data for addiction ‘very, very exciting’

STAT

Early data regarding the use of GLP-1 medications like Ozempic and Wegovy to treat addiction is “very, very, exciting,” Nora Volkow, the director of the National Institute on Drug Abuse, said Thursday. But even as she expressed enthusiasm for the new drugs’ potential, Volkow criticized pharmaceutical companies for neglecting a moral imperative to develop new addiction treatments — but acknowledged that the health system more broadly doesn’t incentivize drug com

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The unique clinical trial challenges faced by digital therapeutics

pharmaphorum

On today’s podcast, host Jonah Comstock is joined by Meri Beckwith, co-founder of Lindus Health, a next-gen CRO that includes digital therapeutics among its specialties. They talk a little bit about the often unseen difficulties of validating a digital therapeutic through a clinical trial.

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PulmCrit Wee: Propofol induced eyelid opening apraxia – the struggle is real

EMCrit Project

Eyelid opening apraxia refers to a specific inability to open the eyelids. This may result from non-dominant hemispheric strokes. On superficial examination it will mimic unconsciousness, but upon further examination the patient is awake and able to respond to stimuli with their extremities. I've seen a similar phenomena of eyelid opening apraxia a few times […] EMCrit Project by Josh Farkas.

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US approves first gene therapy for children with rare genetic disease

Express Pharma

Orchard, which was acquired by Japanese pharmaceutical firm Kyowa Kirin for $477.6 million last year, said it will provide details on the pricing and availability of the therapy later in the week The U.S. health regulator on Monday approved UK-based Orchard Therapeutics’ gene therapy to treat children with metachromatic leukodystrophy (MLD), making it the first approved treatment in the United States for the rare, hereditary disease.

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A study says intermittent fasting is making people drop dead. Oh, come on

STAT

The news is everywhere in my social news feeds this morning: A popular fad diet is apparently lethal, scientific research says. Specifically, a study found that caloric restriction, also known as intermittent fasting, has a 91% risk of death due to cardiovascular disease. Except scientific research doesn’t say that — and not only should you not be worried about this study, you shouldn’t be wasting brain glucose thinking about it.

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Employee experience in healthcare: The importance of EX for patient experience

pharmaphorum

Understanding the employee experience in healthcare is essential for improving the patient experience. Learn more about the importance of employee experience in healthcare and how it impacts patient care.

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CCA: Third of Pharmacy First consultations in 20% most deprived communities

The Pharmacist

Almost a third of Pharmacy First consultations carried out by members of the Company Chemists’ Association (CCA) within the first month of the service were provided in the 20% most deprived communities, new data has suggested. Data from the CCA has this week revealed that ‘just over 3,000’ member pharmacies delivered 48,195 Pharmacy First consultations […] The post CCA: Third of Pharmacy First consultations in 20% most deprived communities appeared first on The Pharmacist.

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Clasp launches with $150M and a plan for precision cancer immunotherapies

BioPharma Dive

The company claims its approach could yield more effective and safer T-cell engagers, a type of cancer medicine that’s attracted significant interest from drugmakers in recent years.

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Opinion: The evidence is clear: A liquid-only diet before a colonoscopy is unnecessary

STAT

Since colorectal cancer is on the rise in people younger than age 50, national guidelines have recently pushed the starting age for colorectal cancer screening down to 45. We need to spread the word. Yet we specialists continue to provide outdated and disproven recommendations on colonoscopy bowel preparation that make the process more difficult for the millions of patients who undergo colonoscopy every year: We tell them to adopt a clear liquid diet the day before their procedure.

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The 3 biggest mistakes we keep making in clinical operations

pharmaphorum

Explore the three major mistakes commonly made in clinical operations that impact patient care, clinical research, and data integrity. Learn how to avoid these pitfalls for successful clinical operations.

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Vaccines in late-stage development hold promise in tackling disease burden: GlobalData

Express Pharma

World Tuberculosis (TB) Day is marked annually on March 24, the anniversary of the discovery of the causative mycobacterium by Dr Robert Koch. The day aims to raise awareness about the devastating health, social, and economic consequences of the disease. It is one of the leading causes of death from an infectious agent, and therefore, efforts are very much needed to eradicate the infection.

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Researchers suggest treatments for rare diseases could reduce burden of kidney disease

Pharma Times

Rare kidney diseases are a group of conditions which account for over 5% of people living with chronic kidney disease

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STAT+: Digital tools for diabetes management did not deliver benefits that justify cost, new report finds

STAT

The last decade has seen billions of dollars flow into digital health companies that promise to improve outcomes for the 38 million Americans living with type 2 diabetes. Their products aren’t cheap, but in the long term, they pitch to health plans and employers that these digital tools will help cut health care costs by preventing serious complications like amputation and kidney failure.

Diabetes 356
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Improving patient engagement and drug development through AI and enhanced medical affairs roles

pharmaphorum

Learn how AI and enhanced medical affairs roles are transforming the landscape of drug development and patient engagement in the health industry. Explore the benefits and advancements in this exciting field.

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NextCure to lay off 37% of staff, dial back research plans

BioPharma Dive

The job cuts at the cancer drug developer will primarily impact manufacturing roles, but will touch on several other parts of the organization, the company said.

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Number of practice pharmacists up 25% in a year

The Pharmacist

The number of pharmacists working in general practices and primary care networks in England increased by 24.5% between December 2022 and December 2023, quarterly statistics from NHS Digital have revealed. And the number of pharmacy technicians working in general practice and PCNs in England has risen by over 40% since December 2022, the statistics reported […] The post Number of practice pharmacists up 25% in a year appeared first on The Pharmacist.

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STAT+: As Humira biosimilars take over the market, CVS has created a new ploy: the drug ‘rebate credit’

STAT

The biggest enticement that large pharmacy benefit managers offer to the employers that hire them is drug rebates — a steady stream of money sent back to their clients, a tangible symbol of the discounts that PBMs are able to wrangle out of pharmaceutical companies. PBMs, the middlemen of drug pricing negotiations, also claim portions of those lucrative rebates for themselves.

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Patient-centricity and HCP engagement: 7 Challenges in pharma and life sciences outreach

pharmaphorum

Discover the top 7 challenges faced by pharmaceutical and life sciences companies in achieving patient-centricity and engaging healthcare professionals (HCPs). Explore strategies to overcome these obstacles for successful outreach efforts.

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FDA approves Idorsia’s Tryvio for treatment of high blood pressure

Pharmafile

Idorsia has announced that the US Food and Drug Administration (FDA) has approved Tryvio (aprocitentan) for the treatment of hypertension in combination with other antihypertensive drugs, to lower blood pressure in adult patients who are not adequately controlled on prior treatments. The drug is an ‘endothelin receptor antagonist that inhibits the binding of endothelin (ET)-1 […] The post FDA approves Idorsia’s Tryvio for treatment of high blood pressure appeared first on Pharmafile.

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Parkinson’s UK grants funding of up to nearly £450,000 to four new research projects

Pharma Times

The globally fast-growing progressive neurological condition affects around 153,000 people in the UK

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Overdose deaths hit another record but show signs of leveling off

STAT

The U.S. recorded 107,941 drug overdose deaths in 2022, according to a new federal report — a total that marks an all-time record but also shows signs that the country’s overdose rate may finally be leveling off after years of steady increase. The 2022 total marks only a slight increase from the drug death toll of 106,699 the year before, according to the Centers for Disease Control and Prevention.

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How will rising demand for mono-material packaging affect pharma?

pharmaphorum

The rising demand for mono-material packaging in the pharmaceutical industry due to its sustainability benefits will have a significant impact. Learn more about how this trend is shaping the future of pharmaceutical packaging.

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Revolutionising outcomes: Agile CROs lead the way

Express Pharma

Clinical trials attest to the safety and efficacy of pharmaceuticals. But, they’re not cheap to conduct. By 2020, out of the mammoth $200 billion pumped into pharma research, a whopping $48.4 billion went into clinical trials. Given the current trajectory, the figures could balloon to $68.9 billion by 2025 and approach $84.44 billion by 2030. CROs: The torchbearers To strike a balance between quality and cost, global pharmaceutical giants have, since 2005, leaned towards Indian clinical re

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Akums introduces Hydroxyurea oral suspension for sickle cell disease

Pharmaceutical Technology

Akums Drugs and Pharmaceuticals has introduced Hydroxyurea oral suspension, a room temperature-stable drug for treating sickle cell disease.

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