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STAT+: New CAR-T company, Brainchild Bio, will focus first on brain tumors in children

STAT

About a decade ago, Mike Jensen, a pediatric oncologist at Seattle Children’s hospital, licensed to a startup his designs for a powerful new type of therapy, called CAR-T, that would re-engineer a child’s own immune cells to target cancer. The deal proved be a mixed blessing. But it was never approved for childhood cancer. 

Immunity 295
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Sanofi adds BTK inhibitors to pipeline with $3.68bn Principia Biopharma acquisition

pharmaphorum

Sanofi’s acquisition builds on a partnership to develop central nervous system drugs that began in late 2017. In a statement Sanofi said that the acquisition will give it full control of the brain-penetrant BTK inhibitor, SAR442168, making marketing more efficient and eliminating any royalty payments due under the 2017 agreement.

Immunity 124
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NK cell immunotherapy: what’s next in clinical development?

European Pharmaceutical Review

He discusses why NK cell therapy’s ability to generate ‘synthetic immunity’ in the body means this modality holds potential as an anti-cancer treatment. We specialise in the development of new cutting-edge immunotherapies , based on the use of therapeutic antibodies capable of activating the immune system to fight cancer.

Immunity 106
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Key vaccine adjuvant biosynthesised

European Pharmaceutical Review

highlighted in the paper a key milestone achieved by the vaccine industry in 2017: “the first saponin adjuvant AS01 was approved for use in a human vaccine, the highly effective shingles vaccine Shingrix (produced by GSK).” “Our Martin et al. Our study opens unprecedented opportunities for bioengineering vaccine adjuvants.

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SAEM Clinical Images Series: Rapidly Spreading Rash

ALiEM - Pharm Pearls

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): An Interplay among Drugs, Viruses, and Immune System. 2017 Jun 9;18(6):1243. Corticosteroids are the mainstay of treatment with gradual tapering over multiple months. References Cho YT, Yang CW, Chu CY. Int J Mol Sci. doi: 10.3390/ijms18061243.

Immunity 177
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SII likely front-runner to win supply of HPV vaccines for Universal Immunisation Program: GlobalData

Express Pharma

India is preparing to include human papillomavirus (HPV) vaccines as part of the government-driven public immunization program popularly known as the Universal Immunization Program (UIP). The Indian government will float a global tender in April 2023 to procure HPV vaccines.

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GSK partners LifeMine on fungi-derived medicines

pharmaphorum

There’s a rich history of finding useful medicines from fungi, from the antibiotic penicillin to immune suppressant cyclosporine and cholesterol drug lovastatin. The examples remain few and far between, however, as in recent decades the pharma industry has turned its attention to synthetic molecules and biologics like antibodies.