pharmaphorum

DECEMBER 4, 2020

The 4 th Antigen Specific Immune Tolerance Digital Summit (ASIT) brings together industry representatives from the fields of autoimmunity, allergy, immuno-oncology and transplantation to tackle the complexities behind autoimmune disorders head on. The post 4th Antigen Specific Immune Tolerance Summit appeared first on.

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Immunity Immunization Medical Schools Drug Development 52

STAT

JANUARY 5, 2023

According to Pitchbook, Fate had 545 employees in 2022, up from 449 recorded in the company’s 2021 annual report. The firm is also dropping one of its experimental drugs, FT596, a cell-based cancer therapy that uses a class of immune cells known as natural killer cells. Continue to STAT+ to read the full story…

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Immunity Immunization 302

pharmaphorum

SEPTEMBER 2, 2021

A US federal judge has approved a bankruptcy settlement for Purdue Pharma that grants the Sackler family that owned the business immunity from any further civil lawsuits accusing them of contributing to opioid epidemic – to the consternation of campaigners. — Washington State Attorney General (@AGOWA) September 1, 2021.

Immunity 101

Immunity Immunization 101

pharmaphorum

FEBRUARY 24, 2021

2021 will be the year when big market access changes – including the far wider use of health economic evaluation – are implemented in Spain. In the latest of a suite of features looking at the biggest markets in Europe, Leela Barham takes stock of what 2021 could bring for market access in Spain. Higher biosimilar savings.

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Biosimilars Immunity Immunization 80

pharmaphorum

DECEMBER 6, 2021

A trial of booster vaccinations to protect against COVID-19 has shown that the jab significantly strengthens the body’s T-cell immunity against the disease. All of these boosted immunity in younger and older people with varying efficacy. The post COVID booster shots increase immunity, trial shows appeared first on.

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Immunity Immunization Vaccines Hospitals 52

pharmaphorum

MARCH 4, 2021

Instead of large phase 3 trials, the MHRA will require studies showing immune responses for tweaked versions of previously approved vaccines, in line with similar guidance issued by the FDA late last month. The post Budget 2021: Sunak focuses on vaccine development to restart economy appeared first on.

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Vaccines Immunity Immunization 105

NY Times

SEPTEMBER 21, 2020

While scientists are rushing to develop an immunization for adults, no one has started the process yet for children.

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Immunity Immunization Vaccines 119

Pharma Marketing Network

DECEMBER 6, 2021

NEW YORK, December 6 th , 2021 (PRNEWSWIRE) – Tap Native, the leading health-focused content discovery platform, today unveiled a list of the top 20 most popular health topics viewed by consumer audiences in 2021. The Top 20 Most Popular Health Topics of 2021 are: 20. Stroke, TIA, blood clot, prevention. Hypertension.

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Diabetes Immunity Immunization Vaccines 52

STAT

APRIL 5, 2024

Sanofi, which is a leading supplier of the vaccine, ceased production of its IPV vaccine in December 2023, triggering concerns among health experts about an imminent supply disruption that may hobble the country’s most ambitious immunization campaign. Sanofi is believed to cater to over 80% of India’s IPV dose requirements.

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Biosimilars Vaccines Immunity Immunization 221

PharmaShots

JUNE 16, 2023

The life science industry saw high deal activity in 2021 staying in the range of an even busier 2020. This article is based on the 2021 biotech and pharma deals data as provided by Chris Dokomajilar of DealForma. 13, 2021 Deal Value: $1.7B 28, 2021 Deal Value: $1.9B

Immunity 40

Immunity Immunization Diabetes 40

pharmaphorum

OCTOBER 12, 2020

SMi Group is delighted to announce the return of the successful 3D Cell Culture Conference for its 5th consecutive year, taking place on 10th and 11th February 2021 as a virtual conference with online access only. Focus Day: 9 February 2021. Conference: 10th – 11th February 2021. Workshop B – 13.30 – 17.30

Immunity 52

Immunity Immunization Drug Development 52

PharmaShots

MARCH 21, 2023

Daratumumab binds to CD38 and inhibits the growth of CD38-expressing tumor cells by inducing apoptosis directly through Fc-mediated cross-linking as well as by immune-mediated tumor cell lysis through complement-dependent cytotoxicity (CDC), antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP).

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Dosage Immunity Immunization 40

FDA Law Blog: Biosimilars

APRIL 30, 2023

Senate Committee on Health, Education, Labor and Pensions (“Senate HELP”) is scheduled to take up legislation that could significantly limit access to the courts and immunize critical FDA decisions from timely judicial review. And in December 2021, we saw FDA apply those factors in responding to a citizen petition (Docket No.

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Immunity Immunization Biosimilars Labelling 59

Pharmacy Times

JANUARY 5, 2024

Adalimumab-aqvh (Yusimry; Coherus Biosciences) entered the market in July 2023, following approval by the FDA in December 2021.

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Immunity Immunization Biosimilars 26

Pharma Mirror

OCTOBER 16, 2023

The first mRNA drug (BNT162b2 vaccine) was granted emergency use authorization by the FDA in December 2020 and approved for marketing in August 2021.

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Immunity Immunization Vaccines 52

Express Pharma

AUGUST 23, 2023

The study was performed to understand whether the immunity gained after vaccination or a prior infection was less effective or “leaky” in situations where people are exposed to high levels of the virus.

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Vaccines Documentation Immunity Immunization 94

European Pharmaceutical Review

NOVEMBER 1, 2023

In its decision to recommend the authorisation, the EMA’s human medicines committee (CHMP) assessed laboratory data showing that the adapted vaccine is able to trigger an adequate immune response against XBB.1.5. 5, it was able to trigger a strong immune response against this strain. The most common side effects with Nuvaxovid XBB.1.5

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Vaccines Immunity Immunization 99

European Pharmaceutical Review

AUGUST 2, 2023

This is an additional ingredient designed to trigger a stronger immune response. The vaccine demonstrated a strong immune response in the trial. In a clinical trial, this vaccine was shown to faciliate a strong immune response against the Omicron BA.1 1 variant, in addition to the original 2020 strain.

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Vaccines Immunity Immunization 97

Express Pharma

APRIL 7, 2023

The findings, published in the journal Environmental Health Perspectives , provide further evidence on the adverse effects of air pollution on the immune system. The team analysed data from 927 participants aged 40 to 65 years, who answered questionnaires and gave blood samples in the summer of 2020 and in the spring of 2021.

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Vaccines Immunity Immunization Diabetes 105

European Pharmaceutical Review

JULY 13, 2023

The field of immunotherapy is constantly evolving with the ultimate goal to develop new treatments that help the body’s immune system fight cancer. Immune cells, such as T cells and natural killer (NK) cells, have the inherent ability to combat diseases, including cancer, but are often inhibited by the body’s own suppressive mechanisms.

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Immunity Immunization Hospitals 88

pharmaphorum

OCTOBER 17, 2022

When James P Allison and Tasuku Honjo were awarded the Nobel Prize for Medicine in 2018 for their discovery of cancer therapy through inhibition of negative immune regulation, it shone a light on decades of research into recruiting the immune system to fight cancer. That’s what makes them such a tricky detective mystery!

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Immunity Immunization Drug Development 108

European Pharmaceutical Review

JANUARY 30, 2024

Pembrolizumab targets a “checkpoint” pathway that is key in enabling cancer cells to avoid being destroyed by the immune system. As a result, the immunotherapy drug supports the immune system’s T cells fight tumours, the researchers highlighted. Based on data from the third interim analysis, completed after a median of 57.2

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Immunity Immunization 90

pharmaphorum

FEBRUARY 25, 2021

A nasal delivery method will also produce an immune response at the point where the virus enters the body. Altimmune’s AdCOVID is an adenovirus-vector vaccine designed to stimulate a broad immune response including both antibody and T-cell responses in the nasal cavity and respiratory tract, the point of entry for the virus.

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Vaccines Immunity Immunization 110

European Pharmaceutical Review

NOVEMBER 25, 2022

Certain RNA methyltransferases regulate RNA sensing and innate immune activation and represent novel immune-regulatory targets. In addition, STC-15 has shown efficacy in leukaemia models via mechanisms including inhibition of leukaemia stem cell function. .”

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Immunity Immunization 85

European Pharmaceutical Review

NOVEMBER 24, 2022

In March 2021, the trial was halted early due to highly significant overall survival (OS) rates in squamous cell carcinoma (SCC) patients. Immune-mediated adverse reactions (ARs) occurred in 21 percent of patients treated with Libtayo ® and led to permanent discontinuation in 4.6 percent), immune-mediated hepatitis (2.4

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Chemotherapy Immunity Immunization Adverse Reactions 88

pharmaphorum

JULY 27, 2022

The vaccine, codenamed BNT162b5, codes for “enhanced” prefusion spike proteins from the original wild-type strain of the virus and the Omicron variant that are designed to increase “the magnitude and breadth of the immune response.” 1 subvariant of Omicron.

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Vaccines Immunity Immunization 122

STAT

MARCH 6, 2023

“I’m slowly running out of options,” said Young, 62, who in November began   receiving   a five-month series of shots at a clinic near her San Francisco home; the vaccine is designed to teach her immune cells to recognize and combat tumors.

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Pharmacy Times

OCTOBER 21, 2022

Researchers suggest that winter 2020 to 2021 public health interventions lowered natural immunity in children and put them at greater risk of respiratory infection after restrictions were lifted.

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Immunity Immunization 40

Pharmaceutical Technology

APRIL 11, 2023

In August 2021, Zydus secured emergency use authorisation (EUA) from the Drugs Controller General of India for its Covid-19 deoxyribonucleic acid (DNA) plasmid vaccine, ZyCoV-D. The vaccine, which generates the SARS-CoV-2 viral spike protein on administration, induces the immune system’s cellular and humoral arm-mediated immune response.

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Immunity Immunization Vaccines 52

Express Pharma

JULY 19, 2023

million children missed out on one or more vaccines delivered through routine immunization services, compared to 24.4 million children in 2021. The vaccine against diphtheria, tetanus, and pertussis (DTP) is used as the global marker for immunization coverage. million zero-dose children in 2021 but remains higher than the 12.9

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Vaccines Immunity Immunization Communication 93

Pharmaceutical Technology

NOVEMBER 14, 2022

Such developments, including a 2021 approval of AstraZeneca’s Saphnelo (anifrolumab) , prompted The Lancet Rheumatology to posit that 2022 could be a “banner year” for the condition. In lupus, the body’s immune system starts to attack its own cells. MSCs and CAR-Ts for lupus.

Immunity 144

Immunity Immunization 144

European Pharmaceutical Review

APRIL 25, 2023

R21/Matrix-M contains Novavax’s saponin-based adjuvant Matrix-M, which enhances immune response, making it more potent and more durable. Its manufacturer highlighted potential manufacturing capacities of over 200 million doses annually. How does the R21/Matrix-M vaccine work?

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Vaccines Immunity Immunization 108

Pharmaceutical Technology

MAY 25, 2023

The results from a trial, published in The New England Journal of Medicine , found the vaccine was associated with a strong immune response and good safety profile. The response was more powerful than that generated by MenACWY-D – a licensed quadrivalent meningococcal vaccine marketed by GSK.

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Vaccines Immunity Immunization 78

pharmaphorum

SEPTEMBER 27, 2022

The principal is much the same as in checkpoint inhibitor treatment: preventing the cancer cells from evading detection by the body’s immune system and highlighting them for destruction by T cells. The ability for cancer cells to create this suppressive tumour microenvironment (TME) allows them to avoid detection by the immune system.

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Vaccines Immunity Immunization 88

Express Pharma

MARCH 20, 2023

India is preparing to include human papillomavirus (HPV) vaccines as part of the government-driven public immunization program popularly known as the Universal Immunization Program (UIP). million in 2021 to 0.54 The Indian government will float a global tender in April 2023 to procure HPV vaccines. per cent from 0.43

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Vaccines Immunity Immunization 52

Pharmaceutical Technology

APRIL 14, 2023

This will suppress the effector characteristics in multiple immune cell subsets. In 2021, Tiziana Life Sciences and FHI Clinical signed an agreement to conduct a Phase II proof-of-concept clinical trial of intranasal foralumab in severe Covid-19 patients hospitalised with pulmonary inflammation in Brazil.

Immunity 98

Immunity Immunization 98

pharmaphorum

JANUARY 10, 2023

Other IgG proteases are being developed to tackle the issue of pre-existing immunity against AAV, but according to Selecta chief executive Carsten Brun these tend to be derived from common human pathogens – which means they themselves can be the target of existing antibodies.

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Immunity Immunization Drug Development 118