Fri.Mar 15, 2024

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What the brains of song birds can teach us about human stuttering

STAT

A symphony of synapses fires every time a songbird sings. For Erich Jarvis, a neurobiologist at Rockefeller University, the neural pathways he finds particularly interesting inside a birds’ brain are those that enable the bird to make new sounds from listening to their environment. This is an ability known as vocal learning, and is perhaps most notably exhibited when a parrot mimics a person’s speech (or profanity).

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After Amylyx drug failure, what’s next for ALS?

PharmaVoice

The company’s combo treatment Relyvrio was approved in 2022, but after failing a phase 3 trial, may be pulled from the market.

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STAT+: FDA advisers back CAR-T therapies in blood cancer, despite safety concerns

STAT

A panel of expert advisers to the Food and Drug Administration on Friday voted in favor of expanding the use of CAR-T therapy in blood cancer, despite concerns about the powerful treatment’s side effects. The group voted 11-0 that the benefits of Carvykti, a CAR-T medicine from Johnson & Johnson and Legend Biotech, outweighed its risk for patients with multiple myeloma whose disease has persisted despite initial treatment.

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SAEM Clinical Images Series: Workout Gone Wrong

ALiEM - Pharm Pearls

A 28-year-old male presented to the ED for evaluation of an injury to his right eye. While working out with an exercise band, it snapped back, hitting the patient in the right eye. He experienced blurry vision and excess eye tearing immediately after the incident occurred. The patient also developed gross blood over the front of the eye. Physical Exam Vitals : Temp 98°F, HR 73, BP (135/77), RR 16, SpO2 99% HEENT : Gross blood in the anterior portion of the right eye (grade I).

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Opinion: Lessons for scientists from the All of Us Research Program backlash

STAT

Scientists are taught early in our training that criticism is a fundamental part of the job. What we are not usually trained to navigate, however, is public backlash, which is exactly what followed the publication of the comprehensive genomic sequencing results from the All of Us Research Program. The study aims to add the genomic information of 1 million volunteers from normally underrepresented genetic backgrounds to datasets that have been mostly constituted by people of European descent.

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Madrigal, FDA approval in hand, outlines plan to sell MASH drug

BioPharma Dive

The company expects initial uptake of Rezdiffra, which costs $47,400 per year, to be slow as doctors and insurers establish the protocols needed to find patients eligible for treatment.

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Pharmacy First payment submission deadline extended again amid IT issues

The Pharmacist

Pharmacy contractors now have until 11.59pm on Thursday 21st March 2024 to submit their payment claims for Pharmacy First services delivered in February, the NHS Business Services Authority (NHSBSA) has announced. It added that contractors should still receive their Pharmacy First payment on 1 May 2024 if they submit their February claim by the revised […] The post Pharmacy First payment submission deadline extended again amid IT issues appeared first on The Pharmacist.

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STAT+: Up and down the ladder: The latest comings and goings

STAT

Hired someone new and exciting? Promoted a rising star? Finally solved that hard-to-fill spot? Share the news with us, and we’ll share it with others.  That’s right. Send us your changes, and we’ll find a home for them.  Don’t be shy. Everyone wants to know who is coming and going. And here is our regular feature in which we highlight a different person each week.

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Navigating digital transformation in pharma: The rise of mobile messaging

pharmaphorum

Popular mobile messaging apps that offer end-to-end encryption for their users' communications means that the content of messages is only accessible to the sender and the recipient. However, like any software, they still have potential cybersecurity risks and compliance concerns that users should be aware of - especially in pharma.

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What happens when an approved drug doesn’t work?

STAT

Want to stay on top of the science and politics driving biotech today?  Sign up  to get our biotech newsletter in your inbox. Hey there. Today, we see the first approval of a drug to treat MASH, a Gilead medication shows huge promise in Ebola, and more.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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Changing Faces: Digital and supplier hires from February 2024

pharmaphorum

Explore the latest digital and supplier hires in the pharmaceutical industry, including Campbell, EMS Healthcare, PhRMA, and Exscientia in February 2024. Stay updated on the changing faces in industry.

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STAT+: Pharmalittle: We’re reading about a liver-drug approval, pharma’s positive outlook, and more

STAT

And so, another working week will soon come to a close. Not a moment too soon, yes? This is, you may recall, our treasured signal to daydream about weekend plans. Our agenda is vague, at the moment. We hope to hang with our fast-moving short person, albeit briefly, promenade with the official mascots, and hold a listening party, where the rotation will likely include this , this , this , this and this.

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Bayer and Aignostics to collaborate on next generation precision oncology

World Pharma News

Bayer and Aignostics GmbH announced a strategic collaboration on several artificial intelligence (AI)-powered approaches with applications in precision oncology drug research and development. Aignostics is a spin-off from one of the world's leading hospitals, Charité-Universitätsmedizin Berlin, and a global leader in using computational pathology to transform complex biomedical data into biology insights.

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8 Ways to Cope with a Disappointing Residency Match 

Board Vitals - Pharmacist

You’ve worked tirelessly through years of medical school, and the culmination of your efforts has finally arrived: the residency match. While you may be excited to have matched, it can be disappointing to realize you matched into a program lower on your preference list, especially as watch your classmates celebrate their own successes. It’s okay to feel disappointed, and it’s natural to have envisioned a different outcome after investing so much time and effort into your medica

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The Case for Domestic Sourcing to Establish Reliable Pharmaceutical Supply Chains in the United States

Pharmaceutical Commerce

Reliance on foreign imports means that disruptions in the supply chain can profoundly impact the ability of individuals in the United States to get access to the medications they need.

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FDA approves first treatment for liver scarring due to fatty liver disease

Pharmafile

The US Food and Drug Administration (FDA) has announced that it has approved Rezdiffra (resmetirom) for the treatment of adult patients with noncirrhotic non-alcoholic steatohepatitis (NASH) with moderate to advanced liver scarring (fibrosis), for use alongside diet and exercise. This approval follows an analysis of the safety and efficacy of the drug based on a […] The post FDA approves first treatment for liver scarring due to fatty liver disease appeared first on Pharmafile.

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Healthee heads latest crop of digital health financings

pharmaphorum

Our latest round-up of funding rounds in the digital health category features updates from Healthee, Aktiia, Moxe Health, Eleanor Health, Tava Health, BrainCheck, and Redi Health.

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GLP1 agonists set to become the best-selling drugs in 2024: GlobalData

Express Pharma

Shift could reflect a changing demand away from oncology toward addressing metabolic disorders GLP1 agonist drugs transformed the weight loss and diabetes landscape in 2023, propelled by robust clinical trial results and a surge in endorsements from celebrities and influencers. While PD1 antagonist drugs currently reign as the top-selling drug class, this status quo is poised for a shift.

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ALS body takes digital approach to clinical trials access

pharmaphorum

The ALS Association is partnering with myTomorrows to connect patients and physicians with clinical trials using a digital platform.

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Pharma gives UCPMP the thumbs up, health activists cry foul

Express Pharma

Health activists raise doubts on pharma associations self-monitoring the code The notification of the Uniform Code for Pharmaceutical Marketing Practices (UCPMP) 2024 on March 12 has been welcomed by major pharma associations, while health activists allege it is a “whitewash.” The notification directs all associations to constitute an Ethics Committee for Pharmaceutical Marketing Practices (ECPMP), set up a dedicated UCPMP portal on their website, and take further necessary steps tow

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Future medicine makers will get VR training at new UK centre

pharmaphorum

Consortium led by Birmingham University unveils a centre of excellence for medicines manufacturing training using VR, to answer a UK skills shortage.

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With FDA greenlight, BMS Breyanzi brings CAR-T cell therapy to CLL and SLL

Pharmaceutical Technology

Amidst the many BTK inhibitors, Breyanzi will be the first and only CAR-T cell therapy available for the treatment of CLL and SLL.

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NIHR reveals phase 1/2 trial to evaluate an investigational vaccine for mpox in the UK

Pharma Times

More than 3,700 cases of mpox have been identified in the UK since May 2022

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Mycoplasma testing market expected to value nearly $2 million by 2031

European Pharmaceutical Review

According to research published by Coherent Market Insights, the global mycoplasma testing market is anticipated to reach $1,907.6 million by 2031. The market is set to witness a compound annual growth rate (CAGR) of 9.7 percent during the forecast period, the report predicted. What is driving and limiting growth in the market? Specifically, technology innovations such as sequencing technology, supported by “strong government funding for biomedical research” in the US has driven rapid developmen

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Madrigal Pharma is first over the MASH finish line

pharmaphorum

Madrigal Pharma is first pharma company to get FDA approval for a drug to treat metabolic dysfunction-associated steatohepatitis (MASH)

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FDA panel backs broader use of J&J, Bristol Myers cell therapies for myeloma

BioPharma Dive

A majority of experts believed that the factors that may have led to an increased risk of early death in testing of Carvykti and Abecma aren’t as likely to occur outside of a clinical trial.

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Anocca signs licensing deal for EmendoBio’s gene-editing tech

Pharmaceutical Technology

Anocca has entered a licensing agreement with EmendoBio for the use of the latter’s OMNI-A4 nuclease, a gene editing technology.

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The Four Key Factors to Evaluate When Insourcing vs. Outsourcing Patient Support Programs

Drug Channels

Today’s guest post comes from Josh Marsh, Vice President and General Manager of Sonexus™ Access and Patient Support at Cardinal Health. Josh discusses factors that drive manufacturers to insource versus outsource patient support services. He shares data from a Cardinal Health survey of biopharmaceutical companies and offers four factors to consider when evaluating your patient support program.

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Analytical technique may advance medical cannabis quality control

European Pharmaceutical Review

Researchers have proposed an advanced analytical technology that can rapidly classify medical cannabis plants at production sites. Using the analytical technique, the plants can be classified “by chemotype using hyperspectral imaging and machine learning (ML),” Markel San Nicolas, researcher in the UPV/EHU’s IBeA group of the University of the Basque Country, and first author of the corresponding research paper explained.

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FDA approves Madrigal’s Rezdiffra as the first NASH therapy

Pharmaceutical Technology

Madrigal’s Rezdiffra received an accelerated approval as a treatment for noncirrhotic NASH, also known as MASH.

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Getting the Lay of the Land After a Banner Year for Biosimilars

Pharmaceutical Commerce

Biosimilars market experiences massive growth, but regulatory and adoption challenges remain.

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Geron leaps as ODAC backs its MDS drug imetelstat

pharmaphorum

Geron rockets after FDA advisory committee backs imetelstat as a treatment for transfusion-dependent myelodysplastic syndromes

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NHS to roll out AI to improve waiting times and reduce missed appointments

Pharma Times

Every year, missed hospital appointments are estimated to cost the NHS £1.

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Bristol Myers cell therapy wins first-of-its-kind approval

BioPharma Dive

Sold as Breyanzi, the therapy is now cleared for use in certain adults with hard-to-treat forms of relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma.

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New tentative approval for Zydus Pharms drug empagliflozin;linagliptin;metformin hydrochloride

Drug Patent Watch

For more information on how DrugPatentWatch can help with your pharmaceutical business intelligence needs, contact admin@DrugPatentWatch.com or visit www.DrugPatentWatch.

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