Wed.Jan 10, 2024

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Nearly 1 in 10 teens globally have used ‘budget Ozempic’ laxatives and other risky weight loss products, per study

STAT

New weight loss medications like Ozempic and Wegovy have garnered a lot of attention in the past year, but they aren’t always easy to get, especially for young people. Instead, teens surfing TikTok often see other options that don’t even require a doctor’s note. Berberine, for example, is a supplement that has been referred to online as “nature’s Ozempic.

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One biotech’s 3 gene therapy hurdles: delivery, delivery and delivery

PharmaVoice

4DMT’s David Kirn is looking to the future of gene therapy with delivery methods that change the paradigm.

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STAT+: Contributors to psychiatry’s bible, the DSM-5, got $14 million from industry

STAT

Amid ongoing concerns over conflicts of interest, a new study found that 60% of the physicians who served as panel and task force members for the American Psychiatric Association’s official manual of psychiatric disorders received payments from industry totaling more than $14 million. And the authors argue the findings raise questions about the editorial independence of the reference book.

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Believe the hype? Mixed signals from AI’s impact on drug development

PharmaVoice

Although AI’s failure rates in drug development still leave room for improvement, today’s missteps feed tomorrow’s successes.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Opinion: Preventing health care violence in the ER requires moving from safety to security

STAT

A slight man falls off his barstool. Now he’s an ER patient, slurring insults and flailing at staff trying to examine him for injuries. When a nurse begs him not to because we don’t know yet whether he has a neck injury, this respectable-looking man in a collared shirt tries to punch her. What’s responsible for such behavior? Too much alcohol?

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Novavax: Creating tomorrow’s vaccines today

pharmaphorum

Novavax is a leading pharmaceutical company dedicated to creating protein-based vaccines for diseases like COVID-19 and malaria. Learn more about their innovative vaccine development process and their commitment to creating a healthier future.

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JP Morgan Week 2024 - Day 2

pharmaphorum

On Day 2 of the JP Morgan 2024 conference, there are exciting presentations from companies such as Daiichi-Sankyo, Recode Therapeutics, and Vir Biotech. The focus was on innovative advancements in healthcare and the contributions of women in the industry. Learn more about the highlights of this day.

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Advocates expect Supreme Court Idaho abortion decision to fuel efforts to further restrict access

STAT

The U.S. Supreme Court’s decision to consider the legality of Idaho’s abortion law — and to reinstate its highly restrictive ban in the meantime — is expected to galvanize a push for similar measures in other states, even before the court issues a ruling later this year. As state legislatures across the country begin their 2024 sessions, advocates on both sides of the abortion debate said they anticipate ongoing efforts to narrow when emergency abortions can be perfor

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Life sciences real estate trends for 2024 and beyond

pharmaphorum

Explore the latest trends and projections in life sciences real estate, including the impact of digital health, the evolving needs of laboratory facilities, and the future of real estate in this sector. Stay ahead of the curve with insights into the industry's future.

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STAT+: At JPM, Verve details plot to take genome editing mainstream

STAT

SAN FRANCISCO — The promise of genome editing has given rise to potentially curative medicines for rare, life-threatening diseases that generally affect small numbers of patients. But since Verve Therapeutics was founded in 2018, it’s had a wider aperture: using the molecular tools of genome editing to go after the most common cause of death in the world.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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5 questions facing pharma in 2024

BioPharma Dive

Many drugmakers hope to compete in obesity, while others seek to win oncology’s next era. In the background, a contentious drug pricing law looms.

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STAT+: U.K. sequencing study surfaces new findings about tumor DNA

STAT

LONDON — A decade ago, the U.K. launched its 100,000 Genomes Project, a major research endeavor that involved sequencing the DNA of that many people to discover how our genes shape our health. But the initiative wasn’t just focused on sequencing our regular DNA. One arm of the project also entailed decoding the genomes of some participants’ tumors.

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Quinolones and Tendon Rupture – Who’s At Risk?

Med Ed 101

To be 100% transparent, I have never personally seen a case of tendon rupture that was likely due to quinolones. I have heard of one from another colleague. It is a very rare adverse effect that has been reported in numerous case studies. What I want you to be aware of in relation to quinolones […] The post Quinolones and Tendon Rupture – Who’s At Risk?

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STAT+: Heated lawsuit between AdventHealth, MultiPlan attracts hospital lobbyists

STAT

A lawsuit between a large hospital system and a dominant vendor that works for health insurance companies is getting a lot more heated — with one party calling the other an “economic parasite.” The suit, between nonprofit hospital giant AdventHealth and MultiPlan, is now even attracting rare interest from the nation’s biggest hospital lobbyists.

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Top 5 pharma marketing trends in 2024

pharmaphorum

Discover the top 5 pharma marketing trends to watch out for in 2024. From personalised marketing strategies to the power of video and omnichannel communication, explore how patient-centric approaches and generative AI are shaping the future of pharmaceutical marketing.

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STAT+: Pharmalittle: We’re reading about Sanofi’s Olympics bet, Singulair problems, and more

STAT

Good morning, everyone, and how are you today? We are doing just fine, thank you. Given that this is already the middle of the week and we have survived this far, no reason not to continue, yes? Just consider the alternatives. In fact, this modest accomplishment calls for celebration. So please join us in quaffing a ritual cup of needed stimulation.

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AbbVie launches pump-based Parkinson’s drug in EU

pharmaphorum

AbbVie has launched its Produodopa therapy for Parkinson’s disease onto the market in the EU, becoming the first and only 24-hour subcutaneous infusion therapy for the neurodegenerative disorder.

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JPM Day 3 had a cautiously optimistic outlook

STAT

In honor of JPM Week, you’re reading a special edition of our biotech newsletter, The Readout. To stay on top of the latest scoops and live reporting from the San Francisco conference,  join our newsletter list. We’ve reached the Wednesday of JPM Week, when gaits get sluggish, voices go hoarse, and early-morning meetings run an increasing risk of cancelation.

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JPM: Precision Bio continues offload of CAR-T rights

pharmaphorum

Precision BioSciences licenses non-cancer uses of its allogeneic CAR-T therapy azer-cel to TG Therapeutics as it pivots to in vivo applications of its gene-editing technology

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Fermion receives IND approval in China for pain relief drug FZ008-145

Pharmaceutical Business Review

A selective second-generation Nav1.8 inhibitor, FZ008-145 is designed to provide non-addictive pain relief. This Nav1.8 target has been clinically validated in five acute pain and one chronic pain proof-of-concept studies. Fermion founder and CEO Dr. Deco Deng said: “In comparison to other therapeutic areas, the central nervous system (CNS) domain presents limited therapeutic options.

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More Gen AI, Direct to Patient Models & Digital Health Top What’s On the Horizon in 2024: Q&A With Scott Snyder, Chief Digital Officer at EVERSANA

PharmExec

Snyder discusses potential trends for various technologies, including AI, digital therapeutics, and virtual reality.

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GPhC acknowledges pressures ‘across all of Great Britain’

The Pharmacist

The General Pharmaceutical Council (GPhC) has acknowledged the high demands faced by pharmacists working ‘across all of Great Britain’, following a challenge from the Pharmacists’ Defence Association (PDA). Last week the PDA questioned how the regulator will treat issues arising from workplace pressures in Scotland and Wales, after the GPhC issued a statement reassuring registrants […] The post GPhC acknowledges pressures ‘across all of Great Britain’ appeared first on The Pharmacist.

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Lupin launches Varenicline Tablets in the US

Express Pharma

Lupin announced the launch of Varenicline Tablets, 0.5 mg and 1 mg, after having received an approval from the United States Food and Drug Administration (US FDA). Varenicline Tablets, 0.5 mg and 1 mg is the generic equivalent of Chantix Tablets, 0.5 mg and 1 mg, of PF Prism C.V. It is indicated for use as an aid to smoking cessation treatment. Varenicline Tablets (RLD Chantix) had estimated annual sales of $412 million in the US.

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Ensuring R&D investments deliver maximum potential: Notable ways to enhance clinical development strategy and design

pharmaphorum

Ensuring R&D investments deliver maximum potential: Notable ways to enhance clinical development strategy and design Mike.

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Akumentis Healthcare launches Clasepi, synthetic CBD for epilepsy

Express Pharma

Akumentis Healthcare has launched Clasepi, a DCGI-approved prescription cannabidiol (CBD] to address seizures linked with Lennox-Gastaut Syndrome (LGS), Dravet Syndrome, or Tuberous Sclerosis Complex (TSC) in patients aged 1 year and older. Clasepi is reportedly the first synthetic CBD product of its kind to be made available in India. A statement from the company states, “The product with THC content below 0.1 per cent, stands out for its non-psychotropic nature.

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Alphabet spinout SandboxAQ buys Good Chemistry

pharmaphorum

Quantum computing and artificial intelligence specialist SandboxAQ has bought Good Chemistry in a deal focused on drug discovery and material science

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Vaccine demonstrates benefit in delaying cancer relapse

European Pharmaceutical Review

A lymph node-targeted cancer vaccine has shown potential to prevent relapse of KRAS-mutated pancreatic and colorectal cancers in patients who have had surgery, according to a Phase I trial led by US researchers. The results were published in Nature Medicine. Results from the cancer vaccine clinical trial In the trial, T cell responses were seen in 84 percent of all patients and in 100 percent of those in the two highest dose cohorts, including those who received the recommended Phase II dose o

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Vertex’s CASGEVY therapy gains approval in Saudi Arabia

Pharmaceutical Technology

Vertex Pharmaceuticals has announced the approval of CASGEVY (exagamglogene autotemcel [exa-cel]), the first CRISPR/Cas9 gene-edited therapy.

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Evotec to advance drug discovery in collaboration with the Crohn’s & Colitis Foundation

Outsourcing Pharma

Evotecâs end-to-end integrated research and development platform will be able to advance drug discovery for two drug targets which is why it has joined forces with the Crohnâs & Colitis Foundation.

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Barinthus Bio announces $47m project to advance MERS coronavirus vaccine

Pharma Times

The partnership will advance VTP-500 from early development to phase 2 clinical trials

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UK study backs whole-genome screening for cancer care

pharmaphorum

UK study led by Genomics England drawing on 100,000 Genomes Project and real-world clinical data backs use of whole-genome sequencing in cancer care

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TIVDAK® supplemental Biologics License Application accepted for Priority Review by FDA for patients with recurrent or metastatic cervical cancer

World Pharma News

Pfizer Inc. (NYSE: PFE) and Genmab A/S (Nasdaq: GMAB) announced that the U.S. Food and Drug Administration (FDA) has accepted the supplemental Biologics License Application (sBLA) seeking to convert the accelerated approval of TIVDAK® (tisotumab vedotin-tftv) to full approval, for the treatment of patients with recurrent or metastatic cervical cancer with disease progression on or after first-line therapy.

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Interview: Grapevine's CEO on piecing together the puzzle for standardized data

Outsourcing Pharma

Clinical data management is a vital phase in clinical research, that should lead to the generation of high-quality, reliable, and statistically sound data from clinical trials.

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Grifols rocked by fraud allegation from short seller

pharmaphorum

Spanish pharma Grifols has refuted claims by hedge fund Gotham City that it has manipulated its financial reporting by hiding exposure to debt.

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Fortrea, Advarra and Veeva form partnership to 'dramatically simplify' clinical trial process

Outsourcing Pharma

Global contract research organization (CRO), Fortrea today announced an industry partnership with founding members cloud solutions company Veeva Systems Inc., and provider of clinical research technology, Advarra.

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