Tue.May 07, 2024

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Opinion: Measles is coming back. My sister Marcie isn’t

STAT

At the end of February 1960, my healthy, precocious sister Marcie was halfway through the fourth grade when she contracted measles from a classmate who lived down the street. Their cases were among the nearly 500,000 that year , before the measles vaccination program began in the U.S. in 1963. For every 1,000 people who get measles, one develops measles encephalitis , which can cause permanent brain damage.

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Using a body as ‘a bioreactor’ — a regenerative medicine expert on where the field is headed

PharmaVoice

The director of the University of Pittsburgh’s McGowan Institute for Regenerative Medicine believes the industry is “turning a corner.

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STAT+: Young boy dies in trial for Pfizer Duchenne gene therapy

STAT

A young boy died in a trial for Pfizer’s experimental gene therapy for Duchenne muscular dystrophy, the company told patient advocates Tuesday. The boy was enrolled in Daylight, a trial studying the treatment in boys aged 2 or 3. The boy had received the therapy early last year, Pfizer told the advocates in a note posted online by Parent Project Muscular Dystrophy.

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Patient dies in Pfizer study of Duchenne gene therapy

BioPharma Dive

Pfizer said the patient, a young boy who was treated earlier last year, had died suddenly. The company is working with trial researchers to investigate further.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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WHO’s top scientist learned a hard lesson about H5N1 two decades ago: Stopping it takes more than biology

STAT

Jeremy Farrar, now the World Health Organization’s chief scientist, was working in Vietnam 20 years ago when the H5N1 virus started to spread across Asia — at that point in poultry. He recalls there was a reluctance among farmers to cull their chickens because they weren’t being compensated for them. Movement of infected birds to evade culling only served to disseminate the virus, which in the years since has spread to all continents except Australia.

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Life sciences in Ireland: Nurturing talent, innovating excellence

pharmaphorum

The life sciences sector in Ireland is booming thanks to nurturing talent and fostering innovation. Companies like Eli Lilly and Regeneron have major operations driving excellence.

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More Trending

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Sorcero genAI conjures plain language from scientific papers

pharmaphorum

Understanding complex scientific studies is often a challenge for patients as well as healthcare professionals, but one that may become easier thanks to artificial intelligence.

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STAT+: Assistants, not replacements: How AI can accelerate research and health care

STAT

When patients are dealing with a sexually transmitted infection, they don’t always get advice on whether they should come into the clinic in a timely fashion. So patient interface company Healthvana created a conversational AI chatbot to quickly answer some of their questions. It had two options: standard AI persona or a drag queen. As it turned out, the rainbow-colored drag queen helped engage more patients.

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Some action points for the next PM

Express Pharma

The US has once again pulled up India for ‘inadequate IP enforcement’ India is one of seven countries to remain on the Priority Watch List of the annual “Special 301 Report” recently released by the US Trade Representative (USTR). The other six countries on the Priority Watch List are Argentina, Chile, China, Indonesia, Russia, and Venezuela.

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STAT+: House panel eyes PBM reform to pay for telehealth extensions

STAT

A new bill set to be considered on Wednesday by the House Ways & Means Committee would extend for two years telehealth flexibilities for Medicare enrollees that were adopted during the Covid-19 pandemic, and look to reform drug industry middlemen to pay for it. At the end of the official public health emergency, Congress extended flexibilities that changed where and what kinds of care people could receive over telehealth, but those rules are set to expire at the end of the year.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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AstraZeneca withdraws Covid-19 vaccine worldwide, citing surplus of newer vaccines

The Guardian - Pharmaceutical Industry

Pharmaceutical company says newer shots led to decline in demand for AstraZeneca vaccine, which is no longer being manufactured or supplied AstraZeneca has begun the worldwide withdrawal of its Covid-19 vaccine due to a “surplus of available updated vaccines” that target new variants of the virus. The announcement follows the pharmaceutical company in March voluntarily withdrawing its European Union marketing authorisation , which is the approval to market a medicine in member states.

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STAT’s Casey Ross and Bob Herman named 2024 Pulitzer Prize finalists

STAT

Dear Readers, We are enormously proud that STAT reporters Casey Ross and Bob Herman have been named finalists for the Pulitzer Prize in the investigative reporting category “for exposing how UnitedHealth Group, the nation’s largest health insurer, used an unregulated algorithm to override clinicians’ judgments and deny care, highlighting the dangers of AI use in medicine.

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NHS to roll out fibre optic laser therapy to prevent seizures in epileptic patients

Pharma Times

The chronic brain disease that causes seizures currently affects around 600,000 people living in the UK

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Vertex starts gene therapy Casgevy in five patients 

STAT

Want to stay on top of the science and politics driving biotech today?  Sign up  to get our biotech newsletter in your inbox. Good morning, incredibly exciting news from the STAT newsroom — two of our reporters, Casey Ross and Bob Herman (or as we call them,  Bob Ross ), were  named Pulitzer finalists  in investigative reporting!

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Pfizer pauses DMD gene therapy trial after boy’s death

pharmaphorum

Pfizer has paused dosing in a study of its Duchenne muscular dystrophy gene therapy after a sudden patient death in another trial

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STAT+: Life science leaders on how to make drug development less expensive, slow, and risky

STAT

Drug development is essentially a long, expensive bet: 90% of drugs fail during clinical trials, goes one of the life science industry’s most oft-quoted statistics. But new ways of identifying and testing therapies, a more precise understanding of disease, and a renewed sense of urgency to address longstanding public health issues could change that dynamic, life science leaders argued this week.

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eyeDNA plans pivotal trial of retinitis pigmentosa therapy

pharmaphorum

Two-year data from a phase 1/2 trial of eyeDNA Therapeutics' gene therapy for retinitis pigmentosa sets up pivotal trials, says the new biotech.

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STAT+: Endo Health ordered to pay more than $1.5 billion in opioid criminal case

STAT

In the second-largest fine ever levied on a pharmaceutical company, Endo Health Solutions was ordered to pay nearly $1.1 billion in criminal penalties and another $450 million in criminal forfeiture for illegally marketing its Opana ER prescription opioid. The company, which last month pleaded guilty to a misdemeanor, admitted that, from April 2012 through May 2013, some of its sales representatives marketed its medicine, also known as oxymorphone, to doctors by touting the drug as abuse deterre

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How to Win Over Your Pharmacy Staff

PioneerRx

It’s one thing to open a pharmacy. Running it is another. But winning your staff over? That’s a whole can of worms. Winning over your pharmacy staff.

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STAT+: Pharmalittle: We’re reading about MDMA for PTSD, a CRISPR treatment for blindness, and more

STAT

Top of the morning to you, and a fine one it is. There is nothing like being greeted with clear blue skies and cool breezes upon waking up today on the Pharmalot campus. Birds are chirping, butterflies are flurrying, and official mascots are barking. And we are similarly engaged in early-in-the-day rituals of our own — firing up the trusty coffee kettle for another cup of stimulation.

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Mapping the Vertical Integration of Insurers, PBMs, Specialty Pharmacies, and Providers: A May 2024 Update

Drug Channels

It's time for Drug Channels ’ annual update of vertical integration among insurers, PBMs, specialty pharmacies, and providers within U.S. drug channels. Below you’ll find our latest illustration of the major vertical business relationships among the largest companies along with some of the notable activity since our previous update. These organizations continue to exert greater control over patient access, sites of care/dispensing, and pricing, although some have started to unwind their vert

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STAT Virtual Event | Navigating a New Era in Alzheimer’s Treatment

STAT

Editor’s note: A livestream of the event will be embedded below at 1 p.m. ET. It took decades for scientists to come up with treatments that could slow the progression of Alzheimer’s disease. Now patients and physicians face a new challenge: actually getting the medicines to people who might benefit from them. Join us for a conversation with a practicing neurologist, neuroscientist and geriatrician about overcoming current hurdles involved in diagnosing, treating, and monitoring pa

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Francis Crick Institute and Broken String Biosciences partner for ALS research

Pharma Times

The rare and fatal progressive neurodegenerative disease is estimated to affect 5,000 people in the UK

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AstraZeneca concludes equity investment in Cellectis

Pharmaceutical Technology

AstraZeneca has concluded an equity investment in clinical-stage biotechnology company Cellectis following a deal signed in November 2023.

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PCI Pharma initiates installation of $100M isolator-based sterile fill-finish site

Outsourcing Pharma

PCI Pharma Services, a global leader in contract development and manufacturing, has embarked on the installation of crucial equipment for its latest sterile fill-finish facility at its Bedford, NH campus in Philadelphia.

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Psilocybin effective in treating depression

Pharmaceutical Technology

A new study has further supported psilocybin's potential to treat depression, which impacts around 300 million people globally.

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Myonex Finalizes Creapharm Deal

Pharmaceutical Commerce

The acquisition, the parties say, will benefit pharma and biotech in the clinical and commercial stages.

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Intravesical drug delivery system exhibits bladder cancer benefit

European Pharmaceutical Review

A novel intravesical targeted drug delivery system for patients with bladder cancer has demonstrated positive data in updated results from a Phase I trial. Johnson & Johnson’s Phase I study is assessing the safety and efficacy of TAR-210 as a delivery method for sustained, local release of erdafitinib into the bladder. The treatment is being evaluated in patients with non–muscle-invasive bladder cancer (NMIBC) with select FGFR alterations.

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Pharmacies could play ‘positive role’ in early cancer diagnosis in deprived areas

The Pharmacist

Patients from the most deprived populations in England are 21% less likely to be referred through the urgent suspected cancer pathway than those from more affluent areas, a recent report has warned. Responding to the findings, the Royal Pharmaceutical Society (RPS) and the chief executive of the Company Chemists’ Association (CCA) highlighted the ‘positive role’ […] The post Pharmacies could play ‘positive role’ in early cancer diagnosis in deprived areas appeared first on The Pharmacist.

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MHRA approves new medicine formulations for HIV prevention

European Pharmaceutical Review

Two new formulations cabotegravir (cabotegravir extended-release injectable suspension and tablets) have been approved by the Medicines and Healthcare products Regulatory Agency ( MHRA ). The treatment consists of Apretude 30mg film-coated tablets and Apretude 600mg prolonged-release suspension for injection. These treatments are indicated for the prevention of sexually transmitted HIV-1 infection — pre-exposure prophylaxis (PrEP) in adults and adolescents weighing at least 35kg with a higher in

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Walgreens to be used as clinical trial sites focusing on obesity and type 2 diabetes

Outsourcing Pharma

Walgreens and Boehringer Ingelheim have joined forces in a move to enhance diversity and accessibility in clinical trials, aiming to make participation more inclusive and equitable.

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Novartis enters agreement to acquire Mariana Oncology, strengthening radioligand therapy pipeline

World Pharma News

Novartis announced that it has entered into an agreement to acquire Mariana Oncology, a preclinical-stage biotechnology company based in Watertown, Massachusetts focused on developing novel radioligand therapies (RLTs) to treat cancers with high unmet patient need. The transaction bolsters the Novartis RLT pipeline and expands the company's research infrastructure and clinical supply capabilities, supporting Novartis strategic priorities in oncology and RLT platform innovation.

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Double ApoE4 gene a 'distinct form' of early Alzheimer’s

pharmaphorum

Having two copies of the ApoE4 gene is not just a risk factor for the development of Alzheimer’s, but is a likely cause of the disease, according to researchers in Spain

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Injectable drug delivery market to value $1139.4b by 2029

European Pharmaceutical Review

A new report by MarketsandMarkets has predicted that the injectable drug delivery market will reach an 8.6 percent compound annual growth rate (CAGR) between 2024 to 2029. The market is anticipated to value $1139.4 billion by 2029. Injectable drugs are adopted widely as treatments for chronic infections such as HIV/AIDS and tuberculosis (TB). Treatment approaches for the latter condition is often a combination of oral antibiotics plus injectable drugs such as rifampin, isoniazid, and streptomyci

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GSK commits to further support of BioVersys’ TB drug

pharmaphorum

GSK commits to further support of BioVersys’ TB drug Phil.

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