ALiEM - Pharm Pearls

OCTOBER 30, 2024

Inpatient wound care teams provided long-term support and a nutrition consult ordered protein, micronutrient, and vitamin supplementation. That discussion can be deferred until the patient is stable, the risk of such an event is mitigated, and other medications can be given for their withdrawal symptoms and pain.

HIV Treatment and Prevention Agents 161

HIV Treatment and Prevention Agents Inpatient Hospitals Diabetes 161

Pharmacy Joe

DECEMBER 29, 2024

With the long duration of therapy needed for CNS infections, adverse events like elevated serum transaminases, neutropenia, and interstitial nephritis can frequently complicate therapy. In addition, nafcillin requires administration every 4 hours which adds to the burden of care.

Hospitals 52

Hospitals Inpatient 52

Pharmacy Joe

DECEMBER 18, 2024

Only 1 of the 5 studies suggested an increase in adverse events with treatment, and this was only nausea and vomiting related events. If you like this post, check outmy book A Pharmacists Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <–

Hospitals 97

Hospitals Inpatient Immunity Immunization 97

Pharmacy Joe

FEBRUARY 9, 2022

In this episode, I’ll discuss an article about serious and general opioid-related adverse drug events. Episode 686: What are the risks for serious and general opioid-related adverse drug events? The authors found that patients at high risk for severe opioid-related adverse events had COPD, neurological failure, or renal disease.

Inpatient 40

Inpatient Hospitals 40

Pharmacy Joe

MARCH 9, 2025

This data was judged to have a low certainty of providing these positive effects, however there is also a low risk of adverse events from melatonin use in ICU patients. In addition, 3 RCTs were pooled together to determine that melatonin improved patients perceptions of sleep quality while in the ICU.

Hospitals 52

Hospitals Inpatient 52

Pharmacy Joe

OCTOBER 11, 2020

In this episode, I’ll discuss how to predict the pharmacotherapy needs of your patient and team during an inpatient medical emergency. If you like this post, check out my book – A Pharmacist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <–

Inpatient 40

Inpatient Hospitals Labelling 40

Pharmacy Joe

MARCH 26, 2023

The authors’ primary endpoint was the rate of adverse events following IVP administration of antibiotics. There were only 10 adverse events observed, half of which were allergic reactions and therefore not related to IVP administration. Results The study evaluated 1000 patients who received IVP antibiotics.

Inpatient 98

Inpatient 98

Pharmacy Joe

MARCH 15, 2023

Secondary outcomes included measures of patient distress, postprocedure length of stay, and adverse events. There was only 1 adverse event in the entire study – a patient who received 4 mcg/kg experienced a decrease in oxygen saturation which resolved after head repositioning.

Hospitals 107

Hospitals Inpatient 107

Express Pharma

MAY 15, 2024

Any grade neurologic events (NEs) occurred in 31 per cent of patients, with Grade > 3 NEs occurring in 10 per cent of patients. Patients in the TRANSCEND FL study were treated in the inpatient and outpatient setting. Treatment process includes leukapheresis, manufacturing, administration, and adverse event monitoring.

Inpatient 110

Inpatient 110

Pharmacy Joe

JULY 1, 2023

Based on this data, in the rare event I am using ketamine for refractory status epilepticus, I use a 2 or 3 mg/kg IV bolus followed by an infusion of at least 1 mg/kg/hr. To access my free download area with 20 different resources to help you in your practice, go to pharmacyjoe.com/free.

Inpatient 105

Inpatient 105

Pharmacy Joe

OCTOBER 6, 2024

In the NEJM study, each of the three medications led to seizure cessation and improved alertness by 60 minutes in approximately half the patients, and the three medications were associated with similar incidences of adverse events.

Inpatient 97

Inpatient 97

Pharmacy Joe

MAY 10, 2023

No patients had hemodynamic instability and there was no difference in adverse events between groups. If you like this post, check out my book – A Pharma cist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <–

Inpatient 105

Inpatient 105

Pharmacy Joe

FEBRUARY 12, 2023

Methylprednisolone 40 mg IV once 4 hours prior to extubation The authors of a recent meta-analysis concluded: Administration of prophylactic corticosteroids before elective extubation was associated with significant reductions in the incidence of post-extubation airway events and reintubation, with few adverse events.

Inpatient 52

Inpatient 52

Pharmacy Joe

AUGUST 10, 2022

The incidence of adverse events and serious adverse events were comparable between the two groups. If you like this post, check out my book – A Pharmacist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <– aeruginosa vs placebo group at day 29.

Inpatient 52

Inpatient 52

Pharmacy Joe

JULY 16, 2024

Adverse events did not differ between tranexamic and placebo groups, including cerebral ischemia and deep venous thrombosis events. absolute reduction in rebleeding events. There was also no effect of treatment on poor functional outcome. The only difference that was in favor of the tranexamic acid group was an 8.7%

Inpatient 52

Inpatient Hospitals 52

Pharmacy Joe

NOVEMBER 6, 2024

The authors sought to compare the efficacy and adverse event profile of 1,000 mg of intravenous acetaminophen to that of 0.5 The secondary outcomes included the need for additional analgesic medication and any adverse events that could be related to the study medication. or more on the 0 to 10 pain scale.

Inpatient 52

Inpatient 52

Pharmacy Joe

JUNE 26, 2024

No lower extremity DVTs or suspected VTE events occurred. Two patients (6%) had significant bleeding events. If you like this post, check out my book – A Pharmacist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <–

Inpatient 52

Inpatient Hospitals 52

Pharmacy Joe

MARCH 26, 2023

The authors’ primary endpoint was the rate of adverse events following IVP administration of antibiotics. There were only 10 adverse events observed, half of which were allergic reactions and therefore not related to IVP administration. Results The study evaluated 1000 patients who received IVP antibiotics.

Inpatient 52

Inpatient 52

Pharmacy Joe

JUNE 21, 2023

The authors note this data is not generalizable to children or patients at higher risk of adverse events. If you like this post, check out my book – A Pharma cist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <–

Inpatient 59

Inpatient 59

Pharmacy Joe

AUGUST 17, 2022

The authors sought to compare the efficacy and adverse event profile of 1,000 mg of intravenous acetaminophen to that of 0.5 The secondary outcomes included the need for additional analgesic medication and any adverse events that could be related to the study medication. or more on the 0 to 10 pain scale.

Inpatient 52

Inpatient 52

Pharmacy Joe

FEBRUARY 12, 2023

Methylprednisolone 40 mg IV once 4 hours prior to extubation The authors of a recent meta-analysis concluded: Administration of prophylactic corticosteroids before elective extubation was associated with significant reductions in the incidence of post-extubation airway events and reintubation, with few adverse events.

Inpatient 40

Inpatient 40

Pharmacy Joe

MAY 29, 2024

The authors evaluated the groups for differences in pain scores at 30 minutes post administration, the need for rescue analgesia, adverse event rates, and the difference in pain scores at 15, 30, 60, 90, and 120 minutes. 75 patients were given a single dose of 0.3 mg/kg of intravenous ketamine and 75 were given 0.75 out of 10 for both groups.

Inpatient 52

Inpatient 52

Pharmacy Joe

NOVEMBER 20, 2022

Only 1 of the 5 studies suggested an increase in adverse events with treatment, and this was only nausea and vomiting related events. If you like this post, check out my book – A Pharmacist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <–

Hospitals 52

Hospitals Inpatient Immunity Immunization 52

Pharmacy Joe

AUGUST 11, 2024

While management of anaphylaxis from sugammadex is no different than from other antigens, clinicians using sugammadex should be especially alert to the possibility of a serious reaction occurring within the first few minutes after administration so that in the rare event anaphylaxis occurs, recognition and treatment is not delayed.

Inpatient 52

Inpatient 52

Pharmacy Joe

AUGUST 10, 2022

The incidence of adverse events and serious adverse events were comparable between the two groups. If you like this post, check out my book – A Pharmacist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <– aeruginosa vs placebo group at day 29.

Inpatient 40

Inpatient 40

Pharmacy Joe

SEPTEMBER 25, 2022

While aspiration was not previously addressed head-on in CAP guidelines, new data prompted the 2019 IDSA CAP guideline authors to include the following question: Question 10: In the Inpatient Setting, Should Patients with Suspected Aspiration Pneumonia Receive Additional Anaerobic Coverage beyond Standard Empiric Treatment for CAP?

Nursing Homes 52

Nursing Homes Inpatient Hospitals 52

Pharmacy Joe

APRIL 16, 2023

Treatment with insulin continued for 72 hours, and the patient achieved a full neurologic recovery other than amnesia of the event. If you like this post, check out my book – A Pharma cist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <–

Inpatient 52

Inpatient Hospitals 52

Pharmacy Joe

JUNE 21, 2023

The authors note this data is not generalizable to children or patients at higher risk of adverse events. If you like this post, check out my book – A Pharma cist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <–

Inpatient 52

Inpatient 52

Pharmacy Joe

SEPTEMBER 10, 2023

mL racemic epinephrine in the event a patient develops post-extubation stridor. If you like this post, check out my book – A Pharmacist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <– To get immediate access, go to pharmacyjoe.com/academy.

Inpatient 52

Inpatient Hospitals 52

Pharmacy Joe

JANUARY 31, 2024

The only difference between infiltration and extravasation is that the former is done with therapeutic intent (such as lidocaine for local anesthesia) and the latter is an unintended event with a harmful medication. Nonpharmacologic treatment of extravasation involves the application of cold or warm compresses to the affected area.

Hospitals 52

Hospitals Inpatient 52

Pharmacy Joe

JANUARY 31, 2024

The only difference between infiltration and extravasation is that the former is done with therapeutic intent (such as lidocaine for local anesthesia) and the latter is an unintended event with a harmful medication. Nonpharmacologic treatment of extravasation involves the application of cold or warm compresses to the affected area.

Hospitals 52

Hospitals Inpatient 52

Pharmacy Joe

SEPTEMBER 10, 2023

mL racemic epinephrine in the event a patient develops post-extubation stridor. If you like this post, check out my book – A Pharmacist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <– To get immediate access, go to pharmacyjoe.com/academy.

Inpatient 52

Inpatient Hospitals 52

Pharmacy Joe

APRIL 16, 2023

Treatment with insulin continued for 72 hours, and the patient achieved a full neurologic recovery other than amnesia of the event. If you like this post, check out my book – A Pharma cist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <–

Inpatient 52

Inpatient Hospitals 52

Pharmacy Joe

DECEMBER 4, 2024

Secondary outcomes were the rate of clinical recovery, the incidence of drug-related adverse events, ICU and hospital mortality. If you like this post, check out my book – A Pharmacist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <–

Hospitals 52

Hospitals Inpatient 52

Pharmacy Joe

SEPTEMBER 25, 2024

in the study however none of the adverse events were rated as severe. If you like this post, check out my book – A Pharmacist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <– Respiratory depression did occur at a rate of 7.7%

Inpatient 52

Inpatient 52

Pharmacy Joe

SEPTEMBER 1, 2024

Despite this, the authors argue that the difference favoring neostigmine is not clinically significant, because the number needed to treat with neostigmine to avoid 1 event is 250. Neostigmine was superior to sugammadex with an estimated odds ratio of 0.83.

Inpatient 52

Inpatient Hospitals 52

Pharmacy Joe

OCTOBER 23, 2022

The clinically relevant outcomes analyzed were ICU admissions, hospital admissions, ED re-admissions, and adverse events in the ED. If you like this post, check out my book – A Pharmacist’s Guide to Inpatient Medical Emergencies: How to respond to code blue, rapid response calls, and other medical emergencies. <–

Hospitals 52

Hospitals Inpatient 52