STAT

APRIL 8, 2024

For the vast majority of pancreatic cancer cases, the tumor grows undetected until it has already spread locally or to distant parts of the body. That’s why we have such a high degree of mortality,” said Ajay Goel, a cancer researcher at the Beckman Research Institute of City of Hope.

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APRIL 28, 2024

Physicians involved with MorphoSys’ completed Phase 3 study have reported multiple cases of palebresib-treated patients who rapidly progressed from myelofibrosis, a cancer affecting the bone marrow, to acute myeloid leukemia, a more aggressive and deadlier type of blood cancer, according to two people with knowledge of the cases.

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APRIL 7, 2024

SAN DIEGO — Cancer cases among younger people have been rising for years, a trend researchers have struggled to explain. Sharing results on Sunday here at the American Association for Cancer Research annual meeting, they found that people born after 1965 were more likely to have a biological age that outpaced their chronological age.

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APRIL 29, 2024

Ono Pharmaceutical of Japan said Monday it will acquire Deciphera Pharmaceuticals, a Boston-based maker of cancer drugs, for $2.4 Deciphera markets a drug called Qinlock for patients with advanced gastrointestinal stromal tumors, or GIST, a type of cancer that begins in the digestive system. Sales last year were $160 million.

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APRIL 30, 2024

A national advisory panel significantly lowered the age recommendations for screening mammography on Tuesday, saying that all women should start breast cancer screening at age 40, rather than 50, and continue every other year until age 74.

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APRIL 7, 2024

But about half of cancer drugs approved via this route fail to improve patient survival or quality of life in subsequent clinical trials after more than five years of follow-up , according to new findings presented Sunday at the American Association for Cancer Research annual meeting. In 2013, it took an average of 9.9

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MAY 9, 2024

Exact Sciences reported first-quarter revenues this week that beat market expectations, and the cancer detection company’s executives still believe they’re on track to meet expected 2024 revenue. That’s usually good news. Yet Exact shares are down nearly 11% on Thursday, dipping to $53.12

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APRIL 10, 2024

SAN DIEGO — Kimryn Rathmell, director of the National Cancer Institute, gestured toward the screen and asked an audience of clinicians, researchers, and patient advocates what they thought they were looking at. Projected behind her was a patchwork of purple, red, pink, and blue squares. ” Read the rest…

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APRIL 11, 2024

Diagnosed at age 3 with acute myeloid leukemia, an aggressive blood cancer, Logan happened to have a targetable mutation that occurs in a small minority of childhood AML cases, making it possible for him to receive a precision therapy drug that — with chemotherapy — got him to a point where he could receive a bone marrow transplant.

Chemotherapy 362

Chemotherapy Hospitals 362

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JANUARY 25, 2024

A historic new study out of Scotland shows the real-world impact of vaccines against the human papillomavirus: The country has detected no cases of cervical cancer in women born between 1988-1996 who were fully vaccinated against HPV between the ages of 12 and 13. Read the rest…

Vaccines 364

Vaccines 364

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MARCH 13, 2024

Doctors have been eagerly waiting for data on Guardant Health’s new blood-based colorectal cancer screening test, the Shield test. The hope has been that Guardant would be able to achieve an elusive goal in colorectal cancer screening: catch incipient or early colorectal cancer using nothing more than two vials of blood.

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DECEMBER 26, 2023

billion for RayzeBio, the companies said Tuesday, buying into the fast-growing field of using targeted doses of radiation to treat cancer. The company is currently running a pivotal trial of its most advanced drug, RYZ101, in neuroendocrine cancer and has a pipeline of treatments for kidney, liver, and other cancers.

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FEBRUARY 8, 2024

But first, a preview of the expected readout from Gritstone Bio’s neoantigen cancer vaccine study. The Gritstone vaccine is designed to train a patient’s own T cells to recognize and kill cancer cells by targeting mutated cancer proteins, called neoantigens, that are unique to a patient’s own tumor.

Vaccines 320

Vaccines 320

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JANUARY 17, 2024

The Food and Drug Administration cleared an AI-powered device for detecting skin cancer on Wednesday, giving primary care physicians a new way to evaluate troubling skin spots. Around 5 million skin cancers are diagnosed each year in the United States. Skin cancer is common, but most types are not that deadly when caught early.

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DECEMBER 27, 2023

Reducing or eliminating alcohol consumption reduces the risk of developing oral cavity and esophagus cancers, according to a special report from the International Agency for Research on Cancer. But more data are needed to conclude whether the same is true for several other cancer types, including colorectal, breast, and liver cancer.

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NOVEMBER 17, 2023

WASHINGTON — President Biden on Friday said he plans to appoint cancer researcher and doctor Kimryn Rathmell to lead the National Cancer Institute. billion agency amid the administration’s efforts to relaunch Biden’s Cancer Moonshot initiative with an emphasis on screening, prevention, and better treatment.

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APRIL 18, 2024

A new startup focused on creating vaccines for cancers, influenza, and potentially even HIV launched Thursday with $54 million in funding. Corner Therapeutics’ Series A round was led by Ziff Capital Partners, a little-known family office started by billionaire Dirk Ziff.

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Vaccines Hospitals 341

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OCTOBER 29, 2023

My husband’s cancer came back this summer after not being evident for almost two years. With advances in cancer surveillance, we now speak of cancer survivors being cancer-free far less frequently.

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DECEMBER 13, 2023

When it comes to cancer, assumptions made by their doctors can undermine their care even before it starts. Clinicians might assume a woman who uses a wheelchair isn’t sexually active so doesn’t need to be tested for HPV, the virus that causes cervical cancer. The potential for pitfalls is vast. Read the rest…

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MARCH 13, 2024

A series of new studies are raising hopes that CAR-T , a process in which treatments are made by genetically editing a patient’s own white blood cells, can eventually be used to treat an incurable and deadly type of brain cancer, called glioblastoma multiforme, or GBM.

Hospitals 360

Hospitals 360

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NOVEMBER 16, 2023

More than a tenth of fecal immunochemical tests, used for routine colorectal cancer screening, contained samples that could not be processed by labs, according to a study published this week in Cancer Epidemiology, Biomarkers and Prevention, a journal of the American Association for Cancer Research.

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APRIL 8, 2024

We have news for you from the annual meeting of the American Association for Cancer Research, and also from the annual meeting of the American College of Cardiology.   Sign up  to get our biotech newsletter in your inbox. Hi, it’s Meghana. Lots happened this past weekend! Interesting stuff. Read the rest…

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SEPTEMBER 26, 2023

Patriarchy isn’t a word that Ophira Ginsburg expected to be at the center of her work as a cancer researcher but, like an infection, it was invading her everyday work as a medical oncologist. Ginsburg and colleagues worldwide joined together to form a Lancet commission  on women and cancer to study this nexus a few years ago.

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NOVEMBER 30, 2023

AbbVie will pay $10 billion for the biotech firm Immunogen, the company said Thursday, acquiring an approved treatment for ovarian cancer and buying into a burgeoning area of oncology. Under the agreement, AbbVie will pay $31.26 per share in cash for Immunogen, a nearly 100% premium to the company’s recent trading price.

Chemotherapy 357

Chemotherapy 357

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MARCH 1, 2024

I recently started a patient with metastatic triple-positive breast cancer patient on a targeted therapy regimen consisting of capecitabine and neratinib, both oral chemotherapy pills that are dosed on a 21-day cycle.

Specialty Pharmacies 316

Specialty Pharmacies Chemotherapy 316

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FEBRUARY 5, 2024

The prediction is dire: Cancer cases around the world are expected to surge 77% by 2050, a new report from the World Health Organization estimates. Women living in low-income countries are less likely to develop breast cancer (1 in 27) than if they lived in a wealthier country (1 in 12).

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AUGUST 4, 2023

Early-stage cancer diagnoses decreased by nearly 20% in the first year of the Covid-19 pandemic. A new study published in Lancet Oncology emphasizes how, because of disruptions in care, patients were more likely to get diagnosed with deadly metastatic disease — across nearly all cancer types. Read the rest…

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JANUARY 22, 2024

Gilead Sciences said Monday that Trodelvy, its “smart-bomb” medicine that combines an antibody with chemotherapy, did not significantly extend the lives of patients with metastatic non-small cell lung cancer when given after a first treatment failed. Continue to STAT+ to read the full story…

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Chemotherapy 348

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OCTOBER 25, 2023

The study , published in JAMA Network Open on Wednesday, found that even among clinical trial participants, disparities still emerged for some groups of breast cancer patients, including young Black and Hispanic patients and Hispanic patients with certain breast cancer subtypes. Read the rest…

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SEPTEMBER 7, 2023

A recent study prompted CNN to report, “Most cancer screenings don’t ultimately give someone extra time beyond their regular lifespan.” ” Does that mean it’s time to dismantle the cancer screening infrastructure in the United States? Probably not. Read the rest…

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OCTOBER 13, 2023

New research shows that some cancer cells can fire a long nanotube projection into the T cell that, like a vampire’s fang, sucks energy-creating mitochondria from the immune cell, turning the predator into prey. It’s just like the cancer cell is too smart.” “This is a new mechanism of immune evasion.

Immunity 363

Immunity Immunization 363

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MAY 23, 2023

In 2023, just under 2 million Americans will be diagnosed with cancer. Fortunately, advances in treatment and novel therapies have steadily improved survival following a cancer diagnosis. Cancer death rates have declined by 27% over the past 20 years. Cancer death rates have declined by 27% over the past 20 years.

Chemotherapy 354

Chemotherapy 354

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OCTOBER 13, 2023

It’s been a busy week for a cancer drug target called PRMT5 that may play a role in treating a variety of solid tumors. Amgen on Friday presented preliminary results from its first study of an experimental pill that selectively blocks the enzyme in cancer cells, showing five partial responses from 31 evaluable patients.

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NOVEMBER 22, 2023

Her husband, Jesse Summers, was diagnosed with metastatic colon cancer in 2021. It went into remission — but earlier this year, a test searching for disease recurrence came back weakly positive, suggesting that the cancer might be back but might not be.

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JANUARY 24, 2024

A year after an investigation revealed widespread use of a substandard cancer drug, the World Health Organization and national drug regulators around the world have come under fire for failing to protect children from the dangerous chemotherapy. But the WHO has issued no alert about the problematic cancer drug. Read the rest…

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Chemotherapy 351

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NOVEMBER 28, 2023

The Food and Drug Administration said Tuesday that it is investigating whether CAR-T therapy, which uses genetically modified white blood cells to attack tumors, can in rare cases cause lymphoma, a blood cancer.

Hospitals 363

Hospitals 363

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FEBRUARY 29, 2024

Pfizer’s current best-seller in oncology, Ibrance for breast cancer, is a small molecule pill.) It said the mix of small molecule drugs in its cancer portfolio will drop from 94% last year to 35% in 2030.

Drug Development 363

Drug Development 363