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The challenge of handling highly potent API and ADCs in analytical chemistry

European Pharmaceutical Review

These molecules are proven to be effective at much smaller dosage levels than traditional APIs. Some examples of HPAPIs are cytotoxic compounds and hormones such as oestrogen. A new compound of unknown potency and toxicity. All dosage forms may utilise HPAPIs including parenteral and solid dosage forms.

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ACMT Toxicology Visual Pearl: Who Doesn’t Like a Nice Rosé?

ALiEM - Pharm Pearls

 Deferoxamine binds with ferric iron (Fe3+) to form ferrioxamine, a water-soluble compound excreted in the urine. As 1,2] Severe symptoms such as hypovolemia, shock, metabolic acidosis Persistent and severe GI symptoms Lethargy or toxic appearance Serum iron level greater than 500 mcg/dL What is the dosage of deferoxamine for iron toxicity?

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Recommended Medical Reference

RX Note

Adverse Drug Reaction Drug Induced Diseases, 2018 Meyler's Side Effects of Drugs, 2015 Antibiotics The Sanford Guide to Antimicrobial Therapy, 2022 Breastfeeding Briggs' Drugs in Pregnancy and Lactation, 2021 Hale's Medications and Mothers' Milk, 2021 Clinical Practice Applied Therapeutics, 2018 Conn’s Current Therapy, 2022 Current Medical Diagnosis (..)