STAT

FEBRUARY 21, 2024

Alison Sbrana was in the belly of an opera when her life changed. Down in the pit, surrounded by fellow orchestra members, she’d been straining to play her flute for half the show. As performers overhead enveloped the audience in arias, Sbrana felt like the Hulk was pulling on the tendons in the right side of her neck. “I begged anybody for meds at intermission,” she said.

Immunity 364

Immunity Immunization 364

PharmaVoice

FEBRUARY 21, 2024

The first-of-its-kind TIL therapy for solid tumors developed by Iovance Biotherapeutics won FDA approval last week.

223

223

STAT

FEBRUARY 21, 2024

SAN FRANCISCO — Outside, the August sun wasn’t yet visible through the thick folds of fog blanketing the San Francisco skyline. Its warmth did not reach the operating room tucked into the sprawling Parnassus Heights hospital complex. In there, the light was all cold and blue fluorescence washing over the sea of scrub caps huddled around an anesthetized young woman on a gurney.

Hospitals 363

Hospitals 363

PharmaVoice

FEBRUARY 21, 2024

A splashy IPO, first-in-class treatments and upcoming approval dates are a few reasons we’ve got our eyes on these biotechs this year.

189

189

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

STAT

FEBRUARY 21, 2024

People with autoimmune disorders don’t usually get to talk about a cure. There’s symptom management, hopeful periods of remission often followed by relapses, but rarely a lasting fix for the way their immune system attacks healthy cells. If the immune system is an army, then those with conditions like lupus, multiple sclerosis, or rheumatoid arthritis are often fighting a never-ending war of friendly fire.

Immunity 362

Immunity Immunization 362

BioPharma Dive

FEBRUARY 21, 2024

The full results spotlight cell therapy’s potential to treat lupus and other inflammatory conditions, but also the problems drug developers must solve first.

Drug Development 122

Drug Development 122

pharmaphorum

FEBRUARY 21, 2024

Clinical research involves trial and error as part of the drug development process. Learn more about how to optimise drug trials and the important role of participants in clinical research.

Drug Development 115

Drug Development 115

STAT

FEBRUARY 21, 2024

Antivenom, like Mexican Coke or grandma’s cookies, is still made the old-fashioned way. In antivenom’s case, the recipe is straightforward: Pump a horse full of sub-lethal doses of venom from various local snakes, wait for them to develop an immune response, tap their blood, purify out antibodies, bottle, and freeze. This vampiric, century-old process still reigns because of the unique scientific challenge posed by snake venoms.

Immunity 317

Immunity Immunization 317

Pharmaceutical Commerce

FEBRUARY 21, 2024

Cabenuva (cabotegravir + rilpivirine) showed superior efficacy in maintaining viral load suppression in patients with HIV compared with standard of care daily oral antiretroviral treatment.

111

111

STAT

FEBRUARY 21, 2024

Usually the words generative AI in health are followed by a bold claim. The technology will transform some aspect of care delivery, save gobs of money, or automate administrative tasks crucial to connecting patients with timely services. Rohit Chandra, chief digital officer of the Cleveland Clinic, said generative AI can accomplish all these things.

Hospitals 314

Hospitals 314

Advertisement

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

Pharmacy Management

Board Vitals - Pharmacist

FEBRUARY 21, 2024

Medical residents play an important role in healthcare, from providing patient care to conducting research and collaborating with healthcare teams. To honor residents and their contributions and sacrifices, we celebrate Thank a Resident Day—a day dedicated to expressing gratitude for these remarkable individuals. What is Thank a Resident Day? Medical residency is a demanding journey filled with long hours, challenging cases, and constant learning.

Medical Schools 105

Medical Schools 105

STAT

FEBRUARY 21, 2024

Recently approved gene therapies offer patients one-time, potentially curative treatments for genetic diseases such as sickle cell anemia and beta thalassemia. But “one-time” miracle solutions can often be multi-month affairs, require millions of dollars, and cause painful side effects. What if that doesn’t have to be the case? In utero gene editing , or prenatal somatic cell genome editing, envisions treating a fetus diagnosed with a genetic disease before birth, thereby pr

233

233

BioPharma Dive

FEBRUARY 21, 2024

One expert views Amtagvi’s approval as a catalyst for further investment in TIL therapies, akin to how Kymriah’s 2017 clearance buoyed CAR-T treatment.

82

82

STAT

FEBRUARY 21, 2024

DarioHealth, which makes apps for managing chronic diseases, today announced it will acquire digital mental health company Twill for $10 million in cash plus stock valued at over $20 million at the end of Tuesday trading. The move is a bet that a consolidated offering can attract a critical mass of large customers in a market where profits have been elusive.

Diabetes 226

Diabetes 226

pharmaphorum

FEBRUARY 21, 2024

Explore the evolution of clinical research in the UK, including the role of NIHR and Direct Delivery Teams in embracing new delivery models. Join our informative webinar to learn more.

101

101

STAT

FEBRUARY 21, 2024

MONTGOMERY, Ala.  — A large Alabama hospital paused in vitro fertilization treatments Wednesday as health care providers weigh the impact of a state court ruling that frozen embryos are the legal equivalent of children. The University of Alabama at Birmingham health system said in a statement that it must evaluate whether its patients or doctors could face criminal charges or punitive damages for undergoing IVF treatments.

Hospitals 204

Hospitals 204

pharmaphorum

FEBRUARY 21, 2024

Attention-deficit hyperactivity disorder (ADHD) in adults is not well understood and highly underdiagnosed, but the developers of a mobile game designed to raise awareness hope to shine a light on the struggles of people struggling with the condition.

100

100

STAT

FEBRUARY 21, 2024

Want to stay on top of the science and politics driving biotech today?  Sign up  to get our biotech newsletter in your inbox. Good morning, everyone. Damian here with a look at the legacy of a pharma CEO, yet more biotech layoffs, and a reprieve from the GLP-1 panic.

Drug Pricing 201

Drug Pricing Drug Development Hospitals 201

Pharmacy Joe

FEBRUARY 21, 2024

In this episode, I’ll discuss the impact of giving epinephrine before defibrillation to in-hospital cardiac arrest (IHCA) patients with shockable rhythms. episode898 Subscribe on iTunes , Android , or Stitcher Knowing when a medication is the first-line treatment for a condition should be easy for pharmacists, as this is exactly what we spend our time on during training and professional development.

Hospitals 98

Hospitals Inpatient 98

Drug Channels

FEBRUARY 21, 2024

Like many of you, I have believed that the Inflation Reduction Act of 2022 (IRA) will encourage Medicare Part D plans to adopt low-list-price products over their high-list/high-rebate counterparts, thereby popping the gross-to-net bubble. Actually, maybe not. Below, I explain why the IRA will encourage Part D plans to prefer high-list, high-rebate specialty drugs , even as the government and manufacturers will prefer a low-list-price version.

Biosimilars 98

Biosimilars 98

Express Pharma

FEBRUARY 21, 2024

Recent regulatory changes have underlined the fissure between the large and mid-MSME segments of the pharma sector. The most recent evidence of this fissure is the representations of the pharma MSME sector to the Prime Minister’s Office (PMO) and to state governments to defer the implementation of the Revised Schedule M of the Drugs Act 1940 that was amended by the Ministry of Health & Family Welfare vide Notification GSR 922 (E) dated December 28 last year.

Pharmaceutical Manufacturing 92

Pharmaceutical Manufacturing 92

pharmaphorum

FEBRUARY 21, 2024

United sues FDA for allowing a marketing application for a competitor to its top-seller Tyvaso, filed by Liquidia, that sidesteps established procedures

100

100

European Pharmaceutical Review

FEBRUARY 21, 2024

Small molecule treatment TAGRISSO ® (osimertinib) demonstrated a “statistically significant and highly clinically meaningful improvement” in progression-free survival (PFS) for Stage III lung cancer patients, AstraZeneca has confirmed. This was established from positive high-level results seen in the LAURA Phase III trial. The data was based on observations from patients with unresectable, Stage III epidermal growth factor receptor-mutated (EGFRm) non-small cell lung cancer (NSCLC) after chemor

Chemotherapy 88

Chemotherapy 88

Express Pharma

FEBRUARY 21, 2024

The pharma landscape has undergone a significant shift towards collaboration and partnership between global big pharma and Indian pharma firms in recent years to drive innovation and expand market reach. This strategic alliance brings together the strengths and resources of both parties to accelerate commercialisation. The focus is on introducing new molecular entities (NMEs) into India, with both parties contributing to accelerate commercialisation and address evolving healthcare needs, finds G

86

86

pharmaphorum

FEBRUARY 21, 2024

FDA and EMA start speedy reviews of Servier’s vorasidenib for IDH-mutated low-grade glioma, hoping to end decades of stagnation in therapies for the brain cancer.

92

92

Express Pharma

FEBRUARY 21, 2024

The top 20 global biopharmaceutical companies experienced varied year-on-year (YoY) market capitalisation shifts in 2023 amid the macroeconomic headwinds, steep patent cliffs and the commencement of US drug price negotiations under the Inflation Reduction Act (IRA). Nonetheless, there was a resilient upturn of 1.6 per cent in aggregate market capitalisation from $3.61 trillion on 31 December 2022 to $3.67 trillion on 31 December 2023, reveals GlobalData.

Drug Pricing 80

Drug Pricing Diabetes Biosimilars 80

pharmaphorum

FEBRUARY 21, 2024

RAPT Therapeutics shares fell sharply after the FDA placed a clinical hold on oral CCR4 antagonist zelnecirnon in atopic dermatitis and asthma.

95

95

Pharma Times

FEBRUARY 21, 2024

Results showed robust responses in patients with pancreatic and colorectal cancer

Vaccines 111

Vaccines 111

Outsourcing Pharma

FEBRUARY 21, 2024

Creating artificial intelligence to understand medical conditions, and not just the English language, sounds far-fetched, but this is what one CEO is achieving with an impressive foundational innovation.

Medical Records 105

Medical Records 105

Pharma Times

FEBRUARY 21, 2024

A streptococcal bacterial infections are estimated to affect around 50 million people worldwide

Immunity 98

Immunity Immunization 98

pharmaphorum

FEBRUARY 21, 2024

DarioHealth has bought fellow digital health company Twill in a move that combines their chronic disease and mental health platforms.

88

88

The Pharmacist

FEBRUARY 21, 2024

Establishment payments for community pharmacy premises and running costs should be considered, Community Pharmacy England (CPE) has told a parliamentary inquiry into pharmacy. In the short term, the negotiator would also like to see increased funding to ‘close the gap’ caused by inflationary costs, as well as the write-off of accrued retained margin, it said. […] The post CPE: Return of establishment payments ‘should be considered’ appeared first on The Pharmacist.

Community Pharmacies 77

Community Pharmacies 77

Pharmaceutical Technology

FEBRUARY 21, 2024

Biora’s new smart pill represents a new treatment modality that may increase the efficacy of therapeutics for ulcerative colitis

84

84

European Pharmaceutical Review

FEBRUARY 21, 2024

Based on data from the Confederation of British Industry (CBI)’s latest monthly Industrial Trends Survey on UK manufacturing, expectations for future selling price inflation rose in February, to their strongest since July 2023. Despite this, the survey noted that selling price expectations remained well below the multi-decade high observed in 2022 (+80 percent in March 2022).

70

70

The Pharmacist

FEBRUARY 21, 2024

The functionality that will allow community pharmacies to update GP patient records with Pharmacy First consultations is in the ‘process of getting ready to go live’, NHS England (NHSE) has said. Since the service launched on 31 January, community pharmacies have been able to send details of patient consultations to GPs via existing processes previously […] The post Pharmacy First GP systems ‘getting ready to go live’ appeared first on The Pharmacist.

Community Pharmacies 75

Community Pharmacies 75