Wed.Aug 09, 2023

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Study mapping how SARS-CoV-2 disrupts mitochondria suggests a cause for long Covid

STAT

In yet another example of Covid’s seemingly limitless reach into our bodies, new research maps out how the SARS-CoV-2 virus disrupts mitochondria, the power plants in all our cells. The extent of the damage, spanning the lungs, heart, liver, kidneys, and brain, could potentially be one explanation for the lengthy list of persistent symptoms of long Covid , from fatigue to brain fog.

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PEM POCUS Series: Pediatric Lung Ultrasound

ALiEM - Pharm Pearls

Read this tutorial on the use of point of care ultrasonography (POCUS) for pediatric lung ultrasound. Then test your skills on the ALiEMU course page to receive your PEM POCUS badge worth 2 hours of ALiEMU course credit. Take the ALiEMU PEM POCUS: Pediatric Lung Ultrasound Quiz Module Goals List indications for performing a pediatric lung point-of-care ultrasound (POCUS).

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‘Underwhelming’: NIH trials fail to test meaningful long Covid treatments — after 2.5 years and $1 billion

STAT

More than 2.5 years after the National Institutes of Health received a $1 billion mandate from Congress to study and treat long Covid , the agency has finally launched clinical trials for the often-debilitating condition. But both scientists who study long Covid and patients who have struggled with it say the trials are unlikely to deliver meaningful treatments, suggesting the federal government’s landmark Covid research effort may have been wasted.

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What pharma companies are getting wrong about drug repositioning

PharmaVoice

Children’s Tumor Foundation president Annette Bakker is working to teach the industry the crucial difference between drug repurposing and drug repositioning.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Study shows autistic people are more likely to engage in self-harm — but not because of autism

STAT

Autistic people are at a much higher risk of self-harm leading to emergency care or suicide, according to a recent study published in JAMA Network Open. In particular, the study found, autistic females had an 83% increased risk of self-harm compared to non-autistic females, while for males, the increased risk compared to non-autistic individuals was 47%.

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Woman of the Week: AmyriaAD’s Sharon Rogers

PharmaVoice

The CEO of the Alzheimer’s-focused biotech discusses its phase 3-ready candidate and what it could contribute to the bustling field.

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More Trending

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GLP-1 Agonists and Gastroparesis

Med Ed 101

There’s always this voice in the back of my head that always cautions me that all that glitters is not gold. After being heralded as the next savior in weight loss by the media, the GLP-1 Agonists/GIP agonists have come under more scrutiny lately in the news. A recent article on CNN details patients who […] The post GLP-1 Agonists and Gastroparesis appeared first on Med Ed 101.

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Nonprofit naloxone maker celebrates FDA approval by donating 200,000 doses

STAT

A nonprofit naloxone manufacturer is celebrating its recent market approval by giving away 200,000 doses of its over-the-counter nasal spray. Harm Reduction Therapeutics said in a statement that it will donate nearly a quarter-million doses of its new product to the Remedy Alliance, an organization devoted to affordable naloxone access. The announcement comes on the heels of the Food and Drug Administration’s approval of Harm Reduction Therapeutics’ product RiVive , a new nasal nal

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Semaglutide cuts risk of cardiovascular events by 20%, claims manufacturer

The Pharmacist

Diabetes drug semaglutide, marketed as Wegovy, could also reduce risk of cardiovascular events by 20%, its manufacturer has claimed. Novo Nordisk has announced headline findings from its SELECT trial, although they have not yet been published in a peer-reviewed journal. The manufacturer said the trial achieved its primary objective of demonstrating a statistically significant reduction of major […] The post Semaglutide cuts risk of cardiovascular events by 20%, claims manufacturer appeared

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STAT+: Wegovy’s successful heart trial raises a vital question about weight loss

STAT

A landmark study that found the blockbuster obesity drug Wegovy reduces the chance of heart problems adds urgency to a basic question in medicine: what exactly is the relationship between weight and health? On its face, the result that Wegovy cut the risk of major cardiovascular complications by 20% lends credence to arguments by drugmakers, including Wegovy manufacturer Novo Nordisk, that obesity is a disease and weight loss makes people healthier.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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Split-sector roles most common across vaccination clinics, practices and PCNs

The Pharmacist

Community pharmacies are most likely to fund split-sector roles in Covid vaccination clinics, general practice and primary care networks (PCNs), a recently published workforce survey has suggested. For the first time, the NHS England (NHSE) Community Pharmacy Workforce Survey 2022 asked pharmacy owners whether they had any staff who were employed by the pharmacy but […] The post Split-sector roles most common across vaccination clinics, practices and PCNs appeared first on The Pharmacist.

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Meet the scientists trying to stop the next global pandemic from starting in Africa

STAT

Even experienced doctors could be fooled by this disease. A deadly hemorrhagic illness, it often looks like yellow fever, malaria, or typhoid. At first, an infected individual might feel weak, uneasy, and feverish; after a few days, headaches, sore throats, and nausea could begin. But in about 20% of infected individuals , patients start to feel like they’re suffocating as fluid leaks into their lungs; as the infection advances, they start bleeding out of their gums, eyes, and nose.

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Artificial Intelligence related patent filings increased in the pharmaceutical industry in Q2 2023

Pharmaceutical Technology

The global pharmaceutical industry experienced a 52% decline in the number of artificial intelligence related patent applications in Q2 2023 compared with the previous quarter, according to GlobalData's Patent Analytics.

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STAT+: ‘No data more personal’: Patients, digital health players weigh in on the FTC’s data privacy plan

STAT

This year has seen the Federal Trade Commission crack down on digital health companies’ irresponsible data use. Since February, it has charged four companies with improperly handling sensitive health information — starting with the first-ever enforcement of its long-stagnant Health Breach Notification Rule, against GoodRx. Now, the FTC is arming itself for even more aggressive enforcement.

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Artificial Intelligence related patent filings increased in the pharmaceutical industry in Q2 2023

Pharmaceutical Technology

The global pharmaceutical industry experienced a 52% decline in the number of artificial intelligence related patent applications in Q2 2023 compared with the previous quarter, according to GlobalData's Patent Analytics.

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CDC director overhauls leadership of center that oversaw response to Covid-19

STAT

The new director of the Centers for Disease Control and Prevention, Mandy Cohen , is overhauling the leadership of the CDC center that led the agency’s Covid-19 response. In an announcement to staff issued Tuesday, Cohen said José Romero, who headed the National Center for Immunization and Respiratory Diseases for the past 14 months, would be leaving the CDC at the end of August.

Immunity 210
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Biocon Foundation, Shakti Sustainable Energy Foundation organise Cities and Climate Action Workshop

Express Pharma

Biocon Foundation, the CSR arm of Biocon Group recently organised a workshop on Cities and Climate Action in association with Shakti Sustainable Energy Foundation (Shakti) at Biocon Campus in Bengaluru. The workshop aimed to foster discussions on strategies and techniques to establish collaboration among NGOs, corporates, and philanthropies. The goal is to collectively address the challenges posed by climate change to the urban centres which are pivotal to the nation’s economic growth.

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Opinion: STAT+: One way to create resilient drug supply chains: incentivize predictive models

STAT

My first exposure to pharmaceutical shortages happened in 2017 as a new-to-practice nurse working on an inpatient oncology unit. A hurricane in Puerto Rico had left the U.S. short of sodium chloride minibags. Health care providers nationwide were tasked to modify standard medication preparation and administration practices, such as changing medications from IV to oral delivery, avoiding prepping IV lines with saline, or providing IV drugs by push rather than infusion.

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ADC oncology therapy market to value over $36b by 2029

European Pharmaceutical Review

According to research from GlobalData, the pharmaceutical industry is shifting towards development of antibody-drug conjugates (ADC) as oncology treatments. The data showed that Daiichi Sankyo , Seagen and Roche are currently three of the most important companies in the ADC market. Daiichi Sankyo was predicted to remain the dominant player in this market.

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Failed clinical trials don’t always spell doom for a new drug. Here’s why

STAT

This article was adapted from STAT’s latest report , “Failed trial, successful drug: how a negative readout can still lead to FDA approval.” W hen a clinical trial readout for what seemed a promising drug comes back negative, investors often contemplate jumping ship and companies wonder if continuing to pursue regulators’ approval is worth the trouble.

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Amarin’s Vazkepa gets green light from SMC

Pharma Times

Treatment will help reduce the risk of heart attacks and strokes for patients across Scotland - News - PharmaTimes

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STAT+: DNA-sequencing giant Illumina slashes 2023 revenue projections

STAT

SAN DIEGO — After starting off the year with lower revenue projections than market analysts had hoped for, San Diego-based genomics giant Illumina lowered expectations again on Wednesday, forecasting annual growth of 1% compared to the previous year. The market’s response was swift. Minutes after the company issued its press release, shares in Illumina dipped from $184.49 to below $172 during after-hours trading.

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Crisis Communication Plans in Pharma

PharmExec

The pharmaceutical industry must have crisis communications prepared now to anticipate unforeseen events—especially those that impact public trust.

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STAT+: Pharmalittle: Wegovy heart study has docs seeing new possibilities; drugmakers file more ‘continuation’ patents that sideline generic rivals

STAT

Good morning, everyone, and how are you today? We are doing just fine, thank you. Given that this is already the middle of the week and we have survived this far, no reason not to continue, yes? Just consider the alternatives. In fact, this modest accomplishment calls for celebration. So please join us in quaffing a ritual cup of needed stimulation — our choice today is the aromatic blueberry cobbler.

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Five Strategies for Dealing with Difficult Pharmacy Patients

The Script

There will most likely come a time when you must deal with a difficult patient. Rx relief weighs in with five strategies you can implement.

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Express Scripts Names New Head of Independent Pharmacy Affairs

Pharmaceutical Commerce

Stephanie Smith Cooney joins PBM business to further develop partnerships, especially with independent pharmacists in local communities.

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Lilly’s reported net income surges 85% in Q2 2023

Pharmaceutical Technology

Eli Lilly and Company has posted reported net income of $1.76bn in the second quarter (Q2) of 2023 as against $952.5m in Q2 2022.

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NASH market holds enormous untapped potential: GlobalData

Express Pharma

The prevalence of nonalcoholic steatohepatitis (NASH), a more advanced stage of nonalcoholic fatty liver disease (NAFLD), continues to increase. Following the receipt of a complete response letter (CRL) from the FDA for its farnesoid X receptor (FXR) agonist, obeticholic acid (OCA), in NASH, Intercept Pharmaceuticals has joined the list of companies who have failed to be the first to enter the NASH market.

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Regeneron ups genetic medicine investment with Decibel buyout

BioPharma Dive

Third Rock-founded Decibel, which has shed much of its value since a 2021 IPO, expected to run out of money within a year.

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Women in Science: KBI Biopharma’s Sigma Mostafa – ‘grit and self-confidence are crucial for success’

Outsourcing Pharma

Sigma Mostafa is the chief scientific officer of KBI Biopharma, a development and contract manufacturing organization serving the biopharmaceutical industry.

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Can a WHO pandemic treaty help poorer nations in future outbreaks?

The Guardian - Pharmaceutical Industry

Global accord aims to avoid the damage caused during Covid-19 and ensure vaccines and medical equipment are distributed equally to all Covid-19 caught the world unprepared; the scramble it prompted for treatments, tests, protective equipment and vaccines favoured the world’s richest nations. To avoid the same thing happening in future pandemics, a group of world leaders has proposed a pandemic treaty, which is being negotiated in a series of international meetings hosted by the World Health Orga

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Sorrento plans stock sale to raise $105m to recover from bankruptcy

Pharmaceutical Technology

The agreement for selling Scilex Holding Company stocks would raise funds to pay off Sorrento’s outstanding debts.

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Interview: eClinical's Nathan Johnson on digital transformation and why he loves his current role

Outsourcing Pharma

Nathan Johnson has 20 yearsâ experience in clinical research as an innovator and programmer with expertise in statistical analysis and reporting, SAS programming, standards development, and data management.

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AGC Biologics expands viral vector manufacturing capabilities in Milan

Pharmaceutical Technology

AGC has extended its Milan manufacturing facility to address the growing clinical trial and commercial demands.

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Will Novartis provide new oral option for chronic hives?

European Pharmaceutical Review

Positive top-line results from Novartis’ Phase III REMIX-1 and REMIX-2 studies showed that remibrutinib 25mg b.i.d. facilitated rapid symptom control for chronic spontaneous urticaria (CSU), also known as chronic hives, within two weeks of treatment. The Bruton’s tyrosine kinase (BTK) inhibitor was evaluated in patients with symptoms inadequately controlled by H1-antihistamines.