Tue.Oct 10, 2023

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The ‘model-eat-model world’ of clinical AI: How predictive power becomes a pitfall

STAT

A growing number of AI tools are being used to predict everything from sepsis to strokes, with the hope of accelerating the delivery of life-saving care. But over time, new research suggests, these predictive models can become a victim of their own success — sending their performance into a nosedive and generating inaccurate, potentially harmful results.

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Research in space yields clues about boosting bone health on Earth

PharmaVoice

A study aimed at helping astronauts decrease bone loss could open the door to novel osteoporosis meds.

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To protect chickens from bird flu, researchers try to CRISPR in immunity

STAT

LONDON — In this case, it was neither the chicken nor the egg that came first. Rather, it started with some specially engineered cells in a lab. The chicken cells had had their genomes edited, not to correct a faulty mutation, but in an effort to blunt the bird flu virus. The chickens that were bred from those cells were designed to be resistant to the infection.

Immunity 323
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Google bets on AI in the life sciences despite nagging concerns

PharmaVoice

A life sciences exec at Google Cloud talks about the future and fears for using AI in pharma.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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STAT+: ‘Like playing the lottery’: A mixed picture for laid-off life sciences workers in Massachusetts

STAT

Gina Calvanese got laid off from Jounce Therapeutics, a struggling Cambridge biotech, in April but landed a higher-paying, six-figure administrative job at a Boston drugmaker within days. Dwight Morrow   was let go by Rubius Therapeutics   five months before it shut down in February. But the veteran scientist quickly moved to a small startup and then got a high-ranking job at Moderna, one of the state’s biggest biotechs, all without leaving Cambridge.

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After summer slump, biotech M&A has a good week

BioPharma Dive

There have been few bigger-ticket acquisitions recently. But a string of deals announced in early October may affirm the forecasts of analysts who expect M&A to tick up in the coming months.

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More Trending

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UKRI awards £41m to enhance UK research and innovation

Pharma Times

The scheme will help ten projects establish research and innovation clusters - News - PharmaTimes

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STAT+: Dana-Farber CEO on Mass General split: Boston needed a dedicated cancer hospital

STAT

One of the first items on Laurie Glimcher’s agenda after becoming CEO of the renowned Dana-Farber Cancer Institute was to build a freestanding cancer hospital in Boston. The most obvious partner would be Mass General Brigham, the large, not-for-profit system that operates the Boston hospital where Dana-Farber’s doctors currently treat cancer patients.

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Bayer opens California plant to make cell therapies

BioPharma Dive

The pharma plans for the new Berkeley facility to produce clinical, and potentially commercial, supplies of a Parkinson’s disease cell therapy being tested by its subsidiary BlueRock.

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With a rare immunodeficiency disease, a performer and patient advocate learned lessons the hard way

STAT

When asked where he’s from, Casey Warford often waffles. He was born in San Antonio, but raised in Georgia, and then moved back to Texas for college. It’s a little complicated because all that time Warford was dealing with a complex medical condition.  The oldest of three children and a couple of close cousins, Warford was a quiet, sleepy baby.

Immunity 296
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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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Life Sciences Innovation Day – Accelerating Digital Transformation Ambition

European Pharmaceutical Review

Schneider Electric, a leader in digital transformation, energy management and automation, has announced the speaker lineup for its exclusive event, Life Sciences Innovation Day – Accelerating Digital Transformation Ambition. Set at the world-renowned Silverstone F1 Racetrack on 18 October 2023, it promises to be a day of immersive insights and top rate networking.

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STAT+: Akero’s treatment for NASH falls short in cirrhosis study

STAT

Akero Therapeutics said Tuesday that an experimental medicine failed to show a significant benefit for patients with cirrhosis caused by NASH, the most advanced and life-threatening stage of the fatty liver disease. While the study’s primary goal of improving liver fibrosis, or scarring, was not achieved, the Akero drug, called efruxifermin, outperformed placebo by 10 percentage points.

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CRF study smashes diversity targets in trials with three times national average

Outsourcing Pharma

Complete clinical trials solution company, Hawthorne Effect, announced today (October 10) announced it had successfully recruited more than 1,000 patients in 48 states plus Hawaii for a study to qualify the prevalence of valvular heart disease (VHD).

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STAT+: Sana to lay off nearly a third of staff, de-prioritize a key program

STAT

Sana Biotechnology, a startup that just a couple of years ago raised over $1 billion off a grand plan to create a portfolio of powerful medicines, said Tuesday it would lay off nearly a third of its employees and de-prioritize one of its most ambitious programs as it looks to save money. The layoffs are Sana’s second round of cuts in less than a year.

Immunity 279
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Study reveals diagnosis and treatment inequalities in NHS heart care

Pharma Times

Researchers focused on four of the most common heart conditions in the UK - News - PharmaTimes

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Opinion: Connecticut’s comptroller explains his thinking about GLP-1s for state employees

STAT

This article is part of a partnership between First Opinion and Tradeoffs, a podcast exploring our confusing, costly, and often counterintuitive health care system. To learn more about how the high price of this new wave of weight loss drugs is causing employers to confront their attitudes about obesity, listen to a deeper dive from Tradeoffs, and  subscribe  to never miss an episode.

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Pharmacy Technology: What You Need to Know

PioneerRx

The healthcare industry is always evolving. New medications and solutions are constantly being developed to optimize your patient’s health in new and innovative.

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STAT+: A fraught question for the children of Alzheimer’s: Is it coming for us?

STAT

My sister has a fantasy about our old age: She imagines that the seven siblings in our family will be living together again, in a house somewhere. Five will be wandering around in bathrobes, lost to dementia. The other two, their minds intact, will look after the lost ones. In this whimsical scenario, for some reason I am one of the two who stay lucid and do the caretaking.

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How commercial employer plans and coverage matter for orphan drugs

Pharmaceutical Technology

In a two-part column, F. Randy Vogenberg delves into why it is important to address emerging challenges in the employer-based US commercial insurance landscape.

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Robert F. Kennedy is pitching centrism on health care, even on abortion

STAT

You’re reading the web edition of D.C. Diagnosis.  Sign up here  to receive this newsletter in your inbox on Tuesdays and Thursdays. What RFK’s new lane means Robert F. Kennedy is officially running for president as an independent. In a Monday afternoon Philadelphia rally, the Kennedy family scion harkened back to the Declaration of Independence and “the one other president who did not have a political party” (George Washington), promising to take on D.C. in

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Economist Impact’s Future of Health Europe summit: Building a sustainable, inclusive, and digital health system

pharmaphorum

Economist Impact’s Future of Health Europe summit: Building a sustainable, inclusive, and digital health system Mike.

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What’s next in the Kaiser Permanente strike

STAT

You’re reading the web edition of Health Care Inc., STAT’s weekly newsletter following the flow of money through the health care system.  Sign up here  to get it in your inbox. The latest with the Kaiser Permanente strike Kaiser Permanente health care workers who went on strike last week notified Kaiser yesterday of future strike plans, my colleague Brittany Trang reports.

Hospitals 210
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ECNP 2023: new esketamine NS safety data for depression

European Pharmaceutical Review

The Janssen Pharmaceutical Companies of Johnson & Johnson has revealed that according to new safety data, SPRAVATO ® (esketamine nasal spray [NS]) has demonstrated superior efficacy compared to quetiapine extended-release (Quetiapine XR) for treatment-resistant depression (TRD). This treatment is an antagonist of the N-methyl-D-aspartate (NMDA) glutamate receptor.

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STAT+: Pharmalittle: Weight-loss drugs fuel boom for firms that fill syringes; employers that cover obesity drug may double in 2024

STAT

Hello, everyone, and nice to see you again. We have returned from an extended weekend respite, which came about thanks to a holiday on this side of the pond. Now, of course, we have returned to the usual routine of digging for interesting items, online calls, and deadlines. This requires a cup or three of stimulation. Our choice today is pistachio creme.

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Importance of Comprehensive Medication Review (CMR) for Your MTM Program

cureatr

The Centers for Medicare & Medicaid Services (CMS) is expected to propose rule changes for Medicare Part D sponsors that will likely require health plans to review and revise their strategies for their medication therapy management ( MTM) programs and delivery of MTM services. Plan sponsors should be particularly attuned to potential changes to requirements governing comprehensive medication review (CMR), especially when such changes coincide with a rapidly growing population of eligible mem

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STAT+: How doctors and nurses shape Google’s AI, DEA extends telehealth flexibilities

STAT

You’re reading the web edition of STAT’s Health Tech newsletter, our guide to how tech is transforming the life sciences.  Sign up to get it  delivered in your inbox every Tuesday and Thursday.  How doctors and nurses shape Google’s AI   At the HLTH conference, I sat down with a suite of Google’s top health execs including chief clinical officer Michael Howell , who leads a team of doctors and nurses who co-develop health products across the c

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Gates Foundation announces $40m for mRNA vaccine platform

Pharmaceutical Technology

The Gates Foundation is providing $40m in funding to advance the accessibility of Quantoom Biosciences' affordable mRNA vaccine platform.

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Want a biotech buyout? Target cancer

STAT

Want to stay on top of the science and politics driving biotech today?  Sign up  to get our biotech newsletter in your inbox. Hope you had a reflective Indigenous Peoples Day. Today, we talk about the implications of Bristol Myers Squibb acquiring Mirati Therapeutics, see a new lung cancer test from liquid biopsy player Delfi Diagnostics, and more.

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AstraZeneca’s Tagrisso to lead lung cancer small molecule market with over $7 bn sales by 2029: GlobalData

Express Pharma

In the ever-evolving landscape of oncology, small-molecule drugs are carving a significant niche in lung cancer treatment. In 2015, AstraZeneca’s Tagrisso achieved landmark approval from the FDA following the results of the Phase III AURA trial. This approval marked a significant advancement in the treatment of metastatic EGFR T790M mutation-positive non-small cell lung cancer (NSCLC).

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Embracing the challenges and opportunities of digital health

pharmaphorum

Embracing the challenges and opportunities of digital health Mike.

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Can immunity from routine vaccines be used to fight cancer?

World Pharma News

A University of Massachusetts Amherst team has demonstrated in theory that a protein antigen from a childhood vaccine can be delivered into the cells of a malignant tumor to refocus the body’s immune system against the cancer, effectively halting it and preventing its recurrence. The bacteria-based intracellular delivering (ID) system uses a non-toxic form of Salmonella that releases a drug, in this case a vaccine antigen, after it's inside a solid-tumor cancer cell.

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LogiPharma USA 2023: Sea vs Air – Identifying Ways to Make International Cold Shipping Efficient and Sustainable

Pharmaceutical Commerce

Session offers insight on how to successfully implement cold chain transport.

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The digital skills you need for customer centric sales

pharmaphorum

The digital skills you need for customer centric sales Mike.

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New patent for NOVO drug WEGOVY

Drug Patent Watch

Annual Drug Patent Expirations for WEGOVY Wegovy is a drug marketed by Novo and is included in one NDA. It is available from two suppliers. There are five patents protecting… The post New patent for NOVO drug WEGOVY appeared first on DrugPatentWatch - Make Better Decisions.

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South Korea: Emerging global leader in life sciences

pharmaphorum

South Korea: Emerging global leader in life sciences Mike.

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