Sat.Jan 14, 2023 - Fri.Jan 20, 2023

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HIV vaccine being developed by Johnson & Johnson fails clinical trial

STAT

Yet another experimental HIV vaccine has failed. The National Institute of Allergy and Infectious Diseases reported Wednesday that a Phase 3 clinical trial of a vaccine was stopped because the vaccine was ineffective at preventing HIV infection. The vaccine was being developed by Janssen, the vaccine division of Johnson & Johnson.

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After ‘limping along,’ Novavax sees a path forward

PharmaVoice

With a new CEO and a long-term booster strategy, the company believes there’s plenty of room to grow in the COVID-19 vaccine space.

Vaccines 274
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AI continues to gain momentum in the biopharmaceutical industry in 2023

Pharmaceutical Technology

While the biopharmaceutical industry has been impacted and pressured by various factors such as the Covid-19 pandemic, inflation, the Ukraine-Russia war, ongoing supply chain issues, and a challenging economic environment, collaboration between pharma companies and emerging technologies providers continues to grow, especially in the research and development (R&D) field, offering some resilience in times of geopolitical and economic disruptions.

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Let’s Get Social: The Ascendancy of Social Media to the Top of the Media Mix

PharmExec

Fran Pollaro talks with Amanda Powers-Han, chief marketing officer at Greater Than One, a full-experience marketing agency dedicated to healthcare, about what’s trending in early 2023 for pharma media mixes.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Mix-it-yourself Wegovy? Some are trying risky sources for weight-loss drugs

STAT

With a few clicks, Daniel added the chemical to his online cart and ordered it. In less than a week, a vial containing white powder arrived at his house. He used a syringe to measure out sterile water and eject it into the vial to dissolve the powder. Then, with a different syringe, he drew up about a quarter of a milliliter of the solution and injected it into his lower abdomen.

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FDA’s 2022 drug approvals fall short of recent norms

PharmaVoice

The U.S. agency’s lower number of novel drug approvals followed several controversies surrounding a 2021 Alzheimer’s approval.

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More Trending

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Hospital Universitario and Josep Carreras develop cell therapy for leukaemia

Pharmaceutical Technology

Spain’s Hospital Universitario 12 de Octubre researchers, along with the Josep Carreras Leukaemia Research Institute, have developed a new cell therapy based on STAb cells to treat a type of leukaemia. The Spanish Association Against Cancer (AECC) provided funding for the new STAb therapy development. It could be used for T-Cell Acute Lymphoblastic Leukaemia (T-ALL) treatment in patients for whom bone marrow transplantation and chemotherapy failed to work.

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A new study links social media use to changes in teen brains. Is that a bad thing?

STAT

Today’s teens and tweens have never known a world without social media. There are still a lot of open questions about how sites like TikTok and Instagram may shape their development — and stories focusing on the potential negative impacts of social media tend to dominate the news. But a recent study published in JAMA Pediatrics is the latest in a growing body of research that suggests the relationship that young people have with social media is too complicated to be categorized as

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Pro sports’ COVID protocols led to real-world data impacts for pharma

PharmaVoice

After years of pioneering new methods for using data and technology to improve patient health outcomes, IQVIA’s Christina Mack is on the cusp of a research revolution.

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Amvuttra recommended by NICE for amyloidosis

Pharma Times

Therapy is among the first to receive a positive draft recommendation under streamlined pilot process

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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UK medical cannabis manufacturer granted GMP registration

European Pharmaceutical Review

The first good manufacturing practice (GMP) registration of a UK pharmaceutical facility for high Δ9-tetrahydrocannabinol (THC) cannabis active pharmaceutical ingredient (API) has been granted since the legalisation of medical cannabis in 2018. Celadon Pharmaceuticals’ Midlands site is now registered by the UK Medicines and Healthcare products Regulatory Agency (MHRA) for GMP manufacturing.

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The addiction crisis is causing a spike in endocarditis cases. Hospitals are struggling to respond

STAT

Increased injection drug use has led to a spike in cases of the life-threatening heart condition endocarditis , with cases rapidly accelerating since the onset of Covid-19. The increased case count is one of the lesser-known side effects of the deadly addiction epidemic. But patients with endocarditis, an inflammation of the heart lining caused by infection, require complex, thoughtful care — care that the U.S. health system is ill-equipped to provide.

Hospitals 304
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The M&A hunt is on — here are the prime targets

PharmaVoice

Companies with advanced molecular therapies, oncology assets and obesity treatments could be fuel for a dealmaking fire this year.

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US eyes link between Pfizer bivalent COVID jab and stroke

pharmaphorum

Regulatory authorities in the US are investigating a possible link between the new Pfizer/BioNTech bivalent COVID-19 booster vaccine and strokes in people aged 65 or over, but still recommend the shots. Monitoring has pointed to a possible higher risk of ischaemic stroke in the 21-day period post-vaccination in this age group compared to 22 to 44 days post-vaccination, according to an announcement on the Centre for Disease Control and Prevention (CDC) website. “Although the totality of the

Vaccines 107
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Scottish Medicines Consortium recommends Merck’s Tepmetko

Pharma Times

Therapy is the first oral MET inhibitor treatment option for certain advanced NSCLC adult patients

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STAT+: Moderna says RSV vaccine worked, setting stage for competition with GSK and Pfizer

STAT

Moderna’s vaccine against the respiratory syncytial virus, or RSV, reduced the rate of lower respiratory disease in people over 60 in a Phase 3 trial, the company said Tuesday. The result will increase competition in a soon-to-be crowded market. The drug giants Pfizer and GlaxoSmithKline have already presented results for their RSV vaccines in older individuals, and have been preparing for what could be a brisk marketing battle.

Vaccines 271
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UBC crowns Bekki Brown as its new CEO with a clear mandate to grow

PharmaVoice

The first-time CEO is tapping into decades of operational expertise to help bring real-world data into the mainstream.

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UK ATMP clinical trials report 2022 published

European Pharmaceutical Review

The Cell and Gene Therapy (CGT) Catapult has published its ‘ UK Advanced Therapy Medicinal Products (ATMP) Clinical Trials Report 2022 ’. In the data, T cells were revealed as the most commonly investigated cell type continuing to increase. The research observed this cell type took up 58 percent of UK ATMP clinical trials in 2022. . Matthew Durdy, Chief Executive of CGT Catapult commented: “It is encouraging to see continued growth of UK clinical trial activity, demonstrating the UK as a favoura

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Celadon receives good manufacturing practice approval

Pharma Times

MHRA approval relates to the company’s midlands-based drug development facilities

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STAT+: Hip and knee replacements go better when performed by high-volume surgeons, new study finds

STAT

A new study underscores the importance of the adage “practice makes perfect,” especially when it comes to surgery. It’s long been understood that the frequency at which surgeons perform and hospitals host complex procedures has a bearing on how patients fare, but the study from the Clarify Health Institute makes the link even clearer.

Hospitals 269
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Woman of the Week: Genetika+’s Talia Cohen Solal

PharmaVoice

The CEO is aiming to build a “brain-in-a-dish” to treat all patients for better mental health outcomes.

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Vaxxas announces CEPI partnership to advance needle-free mRNA vaccine patches

pharmaphorum

Biotech Vaxxas has announced a partnership agreement with the 2017-established Coalition for Epidemic Preparedness Innovations (CEPI), in order to advance the development of Vaxxas’ needle-free vaccine-patch delivery technology with preclinical testing of an mRNA vaccine patch. CEPI is a partnership between public, private, philanthropic, and civil organisations to develop vaccines against future epidemics and pandemics.

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NHS Confederation very concerned by latest industrial action

Pharma Times

Unrelenting pressure caused by strikes, flu and COVID-19 may be keeping NHS in vicious cycle

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In the search for therapies for solid tumors, companies are turning to a novel target: claudin-6

STAT

On Target is a recurring feature from STAT that dives deep into the most promising drug targets in oncology. This column is adapted from the new STAT Report : Targeting cancer: the new frontier of immunotherapy and precision oncology. Targeted immunotherapies like CAR-T have been remarkably successful in combating blood cancers like chronic lymphocytic leukemia.

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A Moderna tie-up ushers in new era for CytomX

PharmaVoice

The antibody-focused company followed up a tough year with big partnerships to keep the ball rolling.

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Governing Principles for Successful Biotechnology Companies

PharmExec

Pete O'Heeron, founder, chairman, and CEO of FibroBiologics, explains the key principles that biotechnology companies should follow.

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Cambridge Cognition buys vocal biomarker firm Winterlight

pharmaphorum

UK digital brain health company Cambridge Cognition has bolstered its speech analysis capabilities with the acquisition of Winterlight Labs of Toronto, Canada, in a cash and stock deal worth £7 million ($8.6 million). The deal extends Cambridge Cognition’s technology in the area of the use of voice-based assessments that can be used to detect and monitor health conditions, and according to the company gives it a platform “that can deliver most of the voice tasks used today by psychol

Immunity 100
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Telehealth patients are scrambling for in-person care amid crackdown on online controlled substances

STAT

Catherine was getting nervous about her ADHD prescription. In 2022, the 29-year-old New Yorker had started using Done, a direct-to-consumer telehealth company that treats attention deficit hyperactivity disorder. The medication her provider had prescribed, a stimulant called Vyvanse, was helping her manage distraction so severe that she frequently had car accidents.

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Lloyds Pharmacy to close all 237 Sainsbury’s outlets

The Guardian - Pharmaceutical Industry

Group says move due to ‘changing market conditions’ as industry warns of insufficient government funding Lloyds Pharmacy is closing all 237 of its outlets in Sainsbury’s supermarkets amid fears of insufficient government funding for the industry. The group said it was making the closures – which are thought to affect about 2,000 jobs – “in response to changing market conditions”, adding it was “currently exploring options for each individual branch”.

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Moderna takes aim at global expansion plans with manufacturing ramp-up

Pharmaceutical Technology

This week, at the World Economic Forum Annual Meeting, Moderna CEO Stéphane Bancel, said the company plans to build on its exponential growth through the pandemic by expanding its operations globally over the next few years. In 2020, Moderna made a net loss of $747 million while its investigational mRNA vaccines were under development. However, during the Covid-19 pandemic, the US-based biotech rose to prominence as it was one of the first companies to develop Covid-19 vaccines with its mRNA tec

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Tips for Managing Drug Shortages at Your Pharmacy

Digital Pharmacist

Drug shortages come in all shapes and sizes. They can be caused by numerous factors and disrupt the quality of care our patients are used to. Within this blog, we will look deeper into the causes of drug shortages and what your pharmacy can do to manage them. What is a Drug Shortage? Let’s start off with what a drug shortage is. A drug shortage is a supply issue that affects how the pharmacy prepares or dispenses a drug product.

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In a post-Dobbs world, pathologists who study pregnancy loss walk a thin line between medicine and the law

STAT

When Mana Parast examines a placenta, she knows she may never find the answers she seeks. She’s hunting for clues — strips of dead tissue that signal autoimmune disease, white blood cells in the lining of the umbilical cord that point to an infection, thickening that could suggest blood wasn’t flowing freely to the fetus. She wants to be able to tell a parent what she thinks went wrong.

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Alabama town learns farmer secretly paid people’s pharmacy bills

The Guardian - Pharmaceutical Industry

Hody Childress donated $100 a month for neighbors who couldn’t pay their prescriptions until his recent death A small town in Alabama is honoring a man who paid off his neighbors’ pharmacy bills for years and kept his generosity a secret until shortly before his recent death by picking up exactly where he left off. Hody Childress, a farmer and US air force veteran, began his anonymous charitable campaign when he walked into a drug store in his home town of Geraldine in 2012 and learned from the

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US FDA grants Fast Track status for Avidity’s AOC 1020 to treat FSHD

Pharmaceutical Technology

The US Food and Drug Administration (FDA) has granted Fast Track designation for Avidity Biosciences’ AOC 1020 to treat facioscapulohumeral muscular dystrophy (FSHD). AOC 1020 has been designed for the treatment of the underlying cause of FSHD, which is caused by the abnormal expression of a gene known as double homeobox 4 or DUX4. This DUX4 protein abnormal expression leads to modifications in gene expression in muscle cells which are associated with progressive muscle function loss in FSHD pat

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Driving clinical trial innovation forward with precision medicine

pharmaphorum

Late last year, pharmaphorum spoke with AstraZeneca’s Ben Challis, VP and head of translational science and experimental medicine, cardiovascular, renal, and metabolism (CVRM), together with Magnus Jörnten-Karlsson, executive director of Unify. Unify, launched in December 2020, is AstraZeneca’s patient app and clinical trial support tool. Already, it is operating at scale across the company, used in more than 28 countries and available in 62 languages.