Research in space yields clues about boosting bone health on Earth
PharmaVoice
OCTOBER 10, 2023
A study aimed at helping astronauts decrease bone loss could open the door to novel osteoporosis meds.
Sat.Oct 07, 2023 - Fri.Oct 13, 2023
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Opinion: Yes, everyone should get an updated Covid-19 vaccine
STAT
OCTOBER 13, 2023
Last month, the Centers for Disease Control and Prevention recommended that everyone in the U.S. 6 months and older receive an updated Covid vaccine targeting the XBB.1.5 variant. Since then, some notable voices, including Paul Offit , have publicly questioned whether the updated vaccine is needed for those who are not in a high-risk group. He recently wrote, “At this point in the pandemic, it is hard to make a case for vaccinating everyone.
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ACMT Toxicology Visual Pearls: A Meal Worth Dying For
ALiEM - Pharm Pearls
OCTOBER 11, 2023
What is the most common primary cause of death from ingesting the pictured marine animal? Acute liver failure Acute renal failure Coagulopathy and DIC Respiratory failure Status epilepticus [Image from Canstockphoto] Reveal the Answer 4. Respiratory Failure The pufferfish, considered a delicacy in multiple countries, contains tetrodotoxin which causes sodium channel blockade and can lead to muscle paralysis, respiratory failure, and death.
A decade later, biotech’s CRISPR revolution is still going strong
BioPharma Dive
OCTOBER 11, 2023
Once the specialty of a few select drugmakers, CRISPR gene editing is now an essential technology for a growing group of biotechs, many led by former students of the field's pioneering scientists.
Position Your Pharmacy for Expansion
Speaker: Chris Antypas and Josh Halladay
Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.
To close the pediatric innovation gap, this biotech has to think differently
PharmaVoice
OCTOBER 11, 2023
Day One Biopharmaceuticals is bucking the cancer drug development trend by working with children and adults simultaneously.
The ‘abortion queen’ wants patients to have ‘skin in the game.’ Is that restricting access?
STAT
OCTOBER 11, 2023
BRISTOL, Va. — Stephanie Rosenwinge was excited to work for the queen of abortion. She’d grown up in rural Virginia with an abusive, alcoholic father. Her mother had had an abortion in 1973, and it may have saved her life: As Rosenwinge put it, “My dad was determined to beat the baby out of her.” Rosenwinge herself had been sexually assaulted while serving in the Gulf War, and she was glad she would’ve had a constitutional right to terminate had the attack resu
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More Trending
Pfizer to cut costs, lay off staff on waning demand for COVID products
BioPharma Dive
OCTOBER 13, 2023
Sales of Pfizer's antiviral Paxlovid and shot Comirnaty have been slower than it anticipated, while a shift to the commercial market for the antiviral has been delayed.
A biotech ‘tuning’ the genome for a potentially safer gene therapy
PharmaVoice
OCTOBER 9, 2023
Tune Therapeutics is hoping to overcome the pitfalls of CRISPR-style treatments with epigenetic editing.
STAT+: In major test for eGenesis, gene-edited pig kidneys kept monkeys alive for more than two years
STAT
OCTOBER 11, 2023
Scientists at a Massachusetts-based biotechnology company and their academic research partners reported Wednesday that an engineered breed of miniature pig containing up to 69 genetic changes produced kidneys that functioned well in monkeys for an average of 176 days and in one animal for more than two years. The results, published in Nature , are an encouraging sign that the long-struggling science of xenotransplantation might one day become a medical reality.
An Evolving ‘Opinion’ Landscape: New Paths—and Synergies—for Pharma KOLs & DOLs
PharmExec
OCTOBER 13, 2023
Industry experts discuss the relationship between digital and traditional (key) opinion leaders and how companies are adjusting their strategies to harness the unique brand engagement benefits each role can provide in driving better patient outcomes.
5 Reasons to Upgrade Your Pharmacy Management Software
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Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.
After summer slump, biotech M&A has a good week
BioPharma Dive
OCTOBER 10, 2023
There have been few bigger-ticket acquisitions recently. But a string of deals announced in early October may affirm the forecasts of analysts who expect M&A to tick up in the coming months.
MHRA issues guidance on valproate full pack dispensing
The Pharmacist
OCTOBER 11, 2023
The Medicines and Healthcare products Regulatory Agency (MHRA) has issued new guidance on full pack dispensing for medicines containing valproate, with regulation changes now in effect. The legislation was amended after a government consultation determined that patients should always receive safety warnings – including a patient card and patient information leaflet contained in full packs […] The post MHRA issues guidance on valproate full pack dispensing appeared first on The Pharmacist.
STAT+: Like a vampire, some cancer cells can suck the energy source from immune cells
STAT
OCTOBER 13, 2023
As elite hunters of the immune system, T cells are constantly prowling our bodies for diseased cells to attack. But when they encounter a tumor, something unexpected can happen. New research shows that some cancer cells can fire a long nanotube projection into the T cell that, like a vampire’s fang, sucks energy-creating mitochondria from the immune cell, turning the predator into prey.
Reviving an R&D Pipeline
Drug Patent Watch
OCTOBER 9, 2023
The article titled “Reviving an R&D Pipeline: A Step Change in the Phase II Success Rate” discusses Pfizer’s efforts to improve its research and development (R&D) productivity. The pharmaceutical industry… The post Reviving an R&D Pipeline appeared first on DrugPatentWatch - Make Better Decisions.
UKRI awards £41m to enhance UK research and innovation
Pharma Times
OCTOBER 10, 2023
The scheme will help ten projects establish research and innovation clusters - News - PharmaTimes
Bayer opens California plant to make cell therapies
BioPharma Dive
OCTOBER 10, 2023
The pharma plans for the new Berkeley facility to produce clinical, and potentially commercial, supplies of a Parkinson’s disease cell therapy being tested by its subsidiary BlueRock.
Treating Rural America: The new country doctors
STAT
OCTOBER 12, 2023
Family medicine physician Olusunmisola Oyesiku always thought she would practice in a big city, but after going through her family residency program at the University of Alabama in Selma, she ended up falling in love with rural medicine. The Selma program is one of a small, but growing, number of residencies in the country that places residents entirely in rural medical settings.
Roche multiple sclerosis subcutaneous injection: late-breaking data
European Pharmaceutical Review
OCTOBER 11, 2023
Late-breaking data from Roche’s Phase III OCARINA II study have revealed that OCREVUS® (ocrelizumab) subcutaneous injection was comparable to IV infusion in providing near-complete suppression of MRI brain lesion activity over 24 weeks, for relapsing or primary progressive multiple sclerosis (RMS or PPMS) patients. OCREVUS is a humanised monoclonal antibody designed to target CD20-positive B cells, which are thought to be a key contributor to myelin and axonal (nerve cell) damage, noted Roche.
Kyowa Kirin to acquire Orchard Therapeutics in deal worth $477m
Pharma Times
OCTOBER 11, 2023
The deal gives Kyowa access to a therapy for early-onset metachromatic leukodystrophy - News - PharmaTimes
Novo Nordisk’s Ozempic shows kidney benefit in large study
BioPharma Dive
OCTOBER 11, 2023
The finding from the study of its diabetes drug, which Novo didn’t detail, could help the company in its competition with rival drugmaker Eli Lilly.
The ‘model-eat-model world’ of clinical AI: How predictive power becomes a pitfall
STAT
OCTOBER 10, 2023
A growing number of AI tools are being used to predict everything from sepsis to strokes, with the hope of accelerating the delivery of life-saving care. But over time, new research suggests, these predictive models can become a victim of their own success — sending their performance into a nosedive and generating inaccurate, potentially harmful results.
Working group to address differential attainment gap for Black trainees
The Pharmacist
OCTOBER 9, 2023
A new working group has been set up to address disparities in attainment and awarding of degrees between Black trainee pharmacists and their White counterparts. The group, led by the Royal Pharmaceutical Society (RPS), also involves the British Pharmaceutical Students' Association (BPSA), the General Pharmaceutical Council (GPhC), NHS England (NHSE), Pharmacy Schools’ Council and representatives […] The post Working group to address differential attainment gap for Black trainees appeared f
UCL researchers recommend AI language models for schizophrenia diagnosis
Pharma Times
OCTOBER 13, 2023
Automated analysis of language could help diagnose and assess psychiatric conditions - News - PharmaTimes
PulmCrit Blogitorial – Why the new brain death guidelines are unacceptable
EMCrit Project
OCTOBER 13, 2023
Hello fellow nerds, let's take a look at the new American Association of Neurology (AAN) brain death guidelines. Instead of a tweetorial, I'll jot my thoughts here, so they're accessible to everyone. Disclaimer: the following discussion applies only to adult medicine. Most of these guidelines are consistent with the 2020 World Brain Death Project, so […] EMCrit Project by Josh Farkas.
He was named a MacArthur ‘genius’ fellow for research on gene regulation, but still has imposter syndrome
STAT
OCTOBER 13, 2023
The youngest of this year’s class of MacArthur “genius grant” fellows, 35-year-old Jason Buenrostro was just a graduate student when he pioneered a technique that’s become a mainstay for studying how cells regulate gene expression. While doing his doctoral work at Stanford University, with geneticists William Greenleaf and Howard Chang, he developed the assay for transposase-accessible chromatin, or ATAC-seq, a highly sensitive and accurate method for identifying regi
Limiting Covid boosters to the over-80s would be more cost-effective
The Pharmacist
OCTOBER 11, 2023
Limiting autumn Covid boosters to the over-80s, and high-risk over-45s, would have been the most cost-effective option, according to a Government impact assessment. But the Joint Committee on Vaccination and Immunisation (JCVI) decided to take a ‘precautionary’ approach in selecting who should be eligible for a booster jab because of uncertainties in the modelling, including […] The post Limiting Covid boosters to the over-80s would be more cost-effective appeared first on The Pharmacist.
UKRI awards three projects £25m for vaccine development
Pharma Times
OCTOBER 13, 2023
The projects will support the development of new and longer-lasting vaccines - News - PharmaTimes
FDA Creates Advisory Committee on Digital Health Technologies
PharmaTech
OCTOBER 11, 2023
The new Digital Health Advisory Committee will advise the agency on issues related to technologies such as AI, virtual reality, and machine learning.
‘What I’m most proud of’: Nick Jonas talks about managing diabetes, his career, and building community
STAT
OCTOBER 11, 2023
LAS VEGAS – Nick Jonas is a global superstar behind electrifying earworms like “Jealous,” “Chains,” and “Sucker,” one-third of the illustrious band The Jonas Brothers — and also a person who lives with type 1 diabetes. He took time out of his world tour to sit down with STAT’s Nicholas St.
How to Use BoardVitals to Prepare for the Longitudinal Knowledge Assessment
Board Vitals - Pharmacist
OCTOBER 9, 2023
Several certifying boards, including the ABIM, have rolled out a new way for practitioners to maintain their certification. In addition to the traditional 10-year maintenance of certification (MOC) exam, the 5-year Longitudinal Knowledge Assessment (LKA) is available for many specialties. Despite its open-book format, the LKA should not be taken lightly.
U.S. FDA approves Pfizer's BRAFTOVI® + MEKTOVI® for BRAF V600E-mutant metastatic non-small cell lung cancer
World Pharma News
OCTOBER 12, 2023
Pfizer Inc. (NYSE: PFE) announced today that the U.S. Food and Drug Administration (FDA) has approved BRAFTOVI® (encorafenib) + MEKTOVI® (binimetinib) for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) with a BRAF V600E mutation, as detected by an FDA-approved test.
Biopharma Stock Check: Market Review and Outlook
PharmExec
OCTOBER 13, 2023
Exploring the pharma and biotech financing, M&A, and stock market pictures through the first half of 2023—and implications for the future, as market challenges continue to weigh heavily in senior management decision-making.
STAT+: Scientists have mapped the human brain in unprecedented detail. They’re just getting started
STAT
OCTOBER 12, 2023
The brain remains both the body’s most important organ and its least understood. But a draft atlas of the human brain published on Thursday gives scientists important insights into how it works and may pave the way for big advances in disease treatment and diagnosis. This brain map, pieced together by hundreds of researchers from San Diego to Seattle to Stockholm, is essentially a cellular “parts list” of the human brain and a guide to how those pieces are arranged and work
SMC recommends Bayer’s cancer treatments for NHS Scotland use
Pharma Times
OCTOBER 11, 2023
Eligible patients in Scotland will now have access to Nubeqa and Stivarga - News - PharmaTimes
EPT and Sexually Transmitted Disease Management
Med Ed 101
OCTOBER 8, 2023
I received a question the other day about EPT (expedited partner therapy) and STD management. State laws vary so be sure to check with your board of pharmacy. In this blog post, we will describe EPT and share what we have learned when looking at the rules from two different states. EPT. What is it? Chances […] The post EPT and Sexually Transmitted Disease Management appeared first on Med Ed 101.
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