STAT

APRIL 23, 2024

… Sanofi will pay more than $100 million to settle about 4,000 lawsuits accusing the drugmaker of failing to warn users that its Zantac heartburn medicine could cause cancer , according to Bloomberg News. But the relatively modest settlement should please Sanofi investors, who worried about the financial fallout of thousands of U.S.

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APRIL 7, 2024

But about half of cancer drugs approved via this route fail to improve patient survival or quality of life in subsequent clinical trials after more than five years of follow-up , according to new findings presented Sunday at the American Association for Cancer Research annual meeting.

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MAY 3, 2024

This is, you may recall, our treasured signal to daydream about weekend plans. And what about you? There is much to do this time of year — the great outdoors are beckoning with mountains to climb, lakes to swim, and beaches to stroll.

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FEBRUARY 5, 2024

The deal, done in part so that Novo can rapidly ramp up its ability to manufacture Wegovy, is a massive statement of optimism about the sales potential of that medication and weight loss drugs like it, known as GLP-1s.

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Vaccines 307

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MARCH 18, 2024

I was wrong about Geron. For years, I’ve believed — and declared publicly — that Geron’s effort to develop a blood cancer drug called imetelstat would end in disappointment. The drug was never getting approved , I said.

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OCTOBER 10, 2023

 To learn more about how the high price of this new wave of weight loss drugs is causing employers to confront their attitudes about obesity, listen to a deeper dive from Tradeoffs, and  subscribe  to never miss an episode. It seems these days like everyone is talking about Ozempic and Wegovy.

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NOVEMBER 28, 2023

I want to empower my patients and their families to make the most appropriate and evidence-based decisions about their care. I am especially worried about drugmakers’ lack of transparency in fully reporting all details of clinical outcomes related to ARIA. Read the rest…

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APRIL 18, 2024

The about-face illustrates the difficulty the biotech industry faces in dealing with an issue that, fueled by national security concerns, is moving fast and forcefully. biotechs from doing business with the Chinese behemoth , STAT says.

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MARCH 29, 2024

This is, you may recall, our treasured signal to daydream about weekend plans. And what about you? Our agenda is still being formulated, but we do hope to promenade with the official mascots, catch up on our reading, and maybe stare at the telly now and then.

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APRIL 19, 2024

This is, you may recall, our treasured signal to daydream about weekend plans. And what about you? And so, another working week will soon draw to a close. Not a moment too soon, yes? Our agenda is still taking shape. However, we do foresee several naps in our future, if only to recover from promenading with the official mascots.

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APRIL 8, 2024

About 230 words into what appeared to be an inspiring email setting out Sanofi’s ambitions — to build “an immunoscience powerhouse, set to accelerate launches and transform the practice of medicine”— Houman Ashrafian, who heads R&D, wrote about “a simplified R&D structure” and layoffs.

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Drug Development 248

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APRIL 12, 2024

This is, you may recall, our treasured signal to daydream about weekend plans. And what about you? As the temperatures warm, this is a fine time to enjoy the great outdoors.

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Drug Development Diabetes Drug Pricing 222

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AUGUST 10, 2023

As demand for Ozempic and Wegovy surges, a little-noticed warning about the medicines was issued recently by regulators.

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FEBRUARY 10, 2024

STAT now publishes selected Letters to the Editor received in response to First Opinion essays to encourage robust, good-faith discussion about difficult issues. Submit a Letter to the Editor  here , or find the submission form at the end of any First Opinion essay.

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MAY 9, 2024

Last month, Sanofi agreed to pay more than $100 million to resolve about 4,000 cases. The agreements cover cases in state courts across the U.S. but do not completely resolve exposure to Zantac claims. Financial details were not available. The settlements come as GSK defends itself in its first U.S.

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APRIL 12, 2024

Want to stay on top of the science and politics driving biotech today?    Sign up  to get our biotech newsletter in your inbox. Hello, everyone. Damian here with what is my final edition of The Readout on my last day at STAT.

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NOVEMBER 20, 2023

Whether you’re a fan of the drug name Zepbound or, like one X user , think it sounds like “an off brand bus line,” you’re likely to have some opinion about the new moniker for Eli Lilly’s blockbuster diabetes drug Mounjaro. The company announced the new name on Nov. Meanwhile, on Nov.

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Diabetes 314

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APRIL 19, 2024

Every so often, the conversations that people in health care have become so pervasive that they dominate the zeitgeist, intersecting with mainstream media and popular culture. Oprah Winfrey’s recent ABC special “Shame, Blame, and the Weight Loss Revolution” is a good example of this.

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OCTOBER 27, 2023

The Food and Drug Administration said on Friday that it has some safety concerns about an experimental CRISPR-based treatment for sickle cell disease, citing the methods used by its makers to evaluate the risk of inadvertently making unwanted changes to patients’ DNA.

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Documentation 349

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FEBRUARY 14, 2024

Meanwhile, you might want to mark your calendar for an upcoming chat about biosimilars. Food and Drug Administration fully approved a Biogen treatment for Alzheimer’s disease, only about 2,000 patients are taking the medicine nationwide , The Boston Globe tell us. We hope you have a lovely day, and do keep in touch.

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Biosimilars 254

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MARCH 22, 2024

This is, you may recall, our treasured signal to daydream about weekend plans. And what about you? Our agenda so far appears quite modest. We plan to catch up on our reading, take a few needed naps and promenade with the official mascots, weather permitting.

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JULY 19, 2023

As the demand for GLP-1 based drugs grows, content about the new class of weight loss drugs on TikTok has fueled the flames of its popularity. Now, the social media platform has taken action against many of the users who post frequently about the medications.

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JANUARY 26, 2024

This is, you may recall, our treasured signal to daydream about weekend plans. And what about you? This is a fine time to curl up with a good book or gaze at one of those moving picture shows everyone is talking about. Our agenda is still shaping up. For now, the rotation will likely include this , this , this and this.

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Drug Pricing 258

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JANUARY 8, 2024

Under the revised guidelines, pharmaceutical companies will have to notify authorities about recalls and also report product defects, deterioration, or faulty production. Previously, there was no requirement to inform authorities about a recall. Small manufacturers, however, have asked for a delay, citing their debt load.

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FEBRUARY 12, 2024

Novo Holdings, the controlling shareholder of Novo Nordisk, plans to invest about $35 billion by 2030 , Reuters writes. Novo Holdings would invest about $5 billion a year in the next five years, and that could go up to $7 billion a year by 2030.

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APRIL 15, 2024

We hope the weekend respite was invigorating and refreshing, because that oh-so familiar routine of phone calls, online meetings, and rushing about has predictably returned. The firm held a nearly 25% stake in Seagen and reaped about $10 billion in proceeds when the acquisition closed in December. But what can you do?

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MARCH 21, 2024

For instance, we are scheduled to have a lively discussion about weight-loss drugs. The price of a four-week supply of Wegovy and Zepbound ranges from about $1,100 to $1,300. Although quite chilly so far, the clear, blue skies and warm sunshine are a heartening elixir for a busy day ahead. Our choice today is orange creme.

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Diabetes 233

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JANUARY 10, 2024

Food and Drug Administration responded to decades of escalating concerns about Singulair, a widely prescribed drug for asthma and allergies, by adding a stark warning on the labeling that it could cause aggression, agitation and even suicidal thought. Once again, we hope you have a successful day and, of course, keep in touch. in December.

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Labelling 259

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JANUARY 16, 2024

In a recent national survey published by the UCSF team in Health Affairs, Ji learned that it’s not just her classmates who may have misconceptions about the FDA — only 17% of physicians surveyed felt they understood the FDA’s device approval process. Around 41% felt they understood the drug side.

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Medical Schools 347

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FEBRUARY 16, 2024

This is, you may recall, our treasured signal to daydream about weekend plans. And what about you? Just a week after dropping the development of a treatment for blood cancers, Gilead Sciences has paused enrollment in clinical trials of the same drug in solid tumors, adding to concerns about its side effects , Pharmaphorum explains. The

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OCTOBER 30, 2023

The one-time treatment was given accelerated approval — a provisional authorization, pending confirmatory data — in June for 4- and 5-year-olds, despite concerns from reviewers about its actual benefit.

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APRIL 30, 2024

The H5N1 bird flu virus has been around for decades, and the damage it wreaks on chickens and other poultry is well documented. But the recent discovery that the virus has jumped into dairy cattle — whose udders seem to be where the virus either infects or migrates to — has dumbfounded scientists and agricultural authorities.

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Documentation 364

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DECEMBER 16, 2023

STAT now publishes selected Letters to the Editor received in response to First Opinion essays to encourage robust, good-faith discussion about difficult issues. medical schools aren’t teaching future doctors about 7.4 Submit a Letter to the Editor here , or find the submission form at the end of any First Opinion essay.

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Medical Schools 247

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JANUARY 23, 2024

About half of them turn out to have dense breast tissue — which makes screening significantly more complicated. Millions of American women over age 40 receive regular mammograms to screen for breast cancer.

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FEBRUARY 9, 2024

This is, you may recall, our treasured signal to daydream about weekend plans. And what about you? But the production was thin on new ideas about how to help patients pay less for medicines, and Sanders’ efforts to goad the executives into lowering prices or freezing their salaries did not work.

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MARCH 25, 2024

WASHINGTON — The Supreme Court on Tuesday will hear opening arguments in an abortion medication case that pharmaceutical companies warn could upend the industry and paralyze new drug development.

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MARCH 19, 2024

Already, the official mascots are racing about the Pharmalot campus in search of breakfast and a steady stream of traffic can be heard nearby. Rise and shine, everyone, another busy day is on the way. As for us, we are engaged in the usual rituals, starting with brewing cups of stimulation.

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