pharmaphorum

SEPTEMBER 30, 2022

Roche’s Genentech unit bought Jecure Therapeutics and its portfolio of NLRP3 drugs in 2018, focusing on peripheral drugs for NASH, liver fibrosis, gout, inflammatory bowel disease, and cardiovascular diseases, and followed that with the takeover of Inflazome with both peripheral and brain-penetrating candidates in 2020.

Drug Development 57

Drug Development 57

PharmaShots

MARCH 24, 2023

PTC Therapeutics’ Upstaza (eladocagene exuparvovec) Receives NICE Recommendation for the Treatment of AADC Deficiency Date: Mar 24, 2023 | Tags: PTC Therapeutics, Upstaza, eladocagene exuparvovec, AADC Deficiency, Regulatory, NICE Onconova Therapeutics Entered into a Research Collaboration with Pangea Biomed to Identify Biomarkers for Cancer (..)

Diabetes 64

Diabetes Immunity Immunization Biosimilars 64

Pharmaceutical Technology

AUGUST 16, 2022

According to the deal, Horizon will provide the funding to develop the therapy until the conclusion of its two Phase II clinical trials. Recently, Q32 concluded a Phase I clinical trial to evaluate the pharmacokinetics, pharmacodynamics and safety of ADX-914, which showed a pharmacological effect on T cells in healthy subjects.

Immunity 52

Immunity Immunization 52

pharmaphorum

SEPTEMBER 22, 2020

The Swiss pharma giant is paying €380 million (around $450 million) upfront for Dublin-based Inflazome, getting rights to a portfolio of oral NLRP3-targeting drugs including two candidates at the clinical testing stage, and has also pledged undisclosed milestone payments.

Immunity 57

Immunity Immunization 57

PharmaShots

MARCH 24, 2023

PTC Therapeutics’ Upstaza (eladocagene exuparvovec) Receives NICE Recommendation for the Treatment of AADC Deficiency Date: Mar 24, 2023 | Tags: PTC Therapeutics, Upstaza, eladocagene exuparvovec, AADC Deficiency, Regulatory, NICE Onconova Therapeutics Entered into a Research Collaboration with Pangea Biomed to Identify Biomarkers for Cancer (..)

Diabetes 40

Diabetes Immunity Immunization Biosimilars 40

pharmaphorum

FEBRUARY 16, 2021

The company hit the headlines last year when one partner – Japan’s Sumitomo Pharma – started clinical trials of a drug candidate for obsessive compulsive disorder, said to be the first medicine developed using AI to enter testing in humans.

Diabetes 117

Diabetes Immunity Immunization 117

Pharmaceutical Technology

FEBRUARY 18, 2023

According to Globaldata, it is involved in 34 clinical trials, of which 20 were completed, 1 is ongoing, and 13 were terminated. The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.

Diabetes 40

Diabetes Generic Medicine Biosimilars Immunity 40

PharmaShots

APRIL 25, 2023

Stock Exchange: NASDAQ Driven by the objective to bring a dynamic portfolio of clinical and pre-clinical assets for the patient’s needs, Arbutus is working steadfastly to mark its dominance in RNAi therapies. R&D Expenditure: $84.4M AB-729 is the lead RNAi asset in the company’s pipeline. R&D Expenditure: $85.1M

HIV Treatment and Prevention Agents 40

HIV Treatment and Prevention Agents Diabetes Packaging Immunity 40

PharmaShots

JANUARY 31, 2023

A series of agreements were made between Nexalin and Wider Come Limited in Sep’18 to form a joint venture entity in Hong Kong to enhance their clinical research and medical device distribution in China, Macau, Hong Kong, and Taiwan. The drug is under development in a pivotal P-II/III clinical trial. Funding Value: $11.4M

Vaccines 40

Vaccines Immunity Immunization Diabetes 40

RX Note

JUNE 3, 2023

A colleague told me that not all pharmacists are professionally trained to perform their clinical service. Should allopurinol be restarted when patient is having gout attack? Is Good Clinical Practice a requirement prior to starts research? Introduction Learning is a never-ending journey. What are examples of COX-2 inhibitors ?

Health and Personal Care Stores 40

Health and Personal Care Stores Chemotherapy Compounding Dosage 40

Med Ed 101

OCTOBER 12, 2022

Is as needed (PRN) allopurinol appropriate? I have seen as-needed (PRN) orders for allopurinol in practice. It has been rare, but it has happened. Did I like it? Allopurinol helps to lower uric acid levels. Allopurinol inhibits xanthine oxidase which is an enzyme that is necessary for the production of uric acid. While the […].

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Med Ed 101

AUGUST 13, 2023

If you work with patients at all, you’ll see some of the most common antihypertensive agents used on a daily basis. The reason they are used so frequently is because they do not tend to have many significant drug interactions.

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pharmaphorum

NOVEMBER 17, 2021

With drug pricing controls back on the legislative table in the US, the influential Institute for Clinical and Economic Review (ICER) has published its third report on “unsupported” price increases – with AbbVie’s Humira top of the list.

Drug Pricing 98

Drug Pricing Biosimilars 98

RX Note

JULY 29, 2023

Nonetheless, there are also circumstances where we have to read up the clinical practice guidelines or clinical journals to justify the dosing of a particular drug, especially those off-label indications. Hence, you may want to look up physical product, MIMS Malaysia or NPRA Quest 3+ Product Search.

Chemotherapy 40

Chemotherapy Labelling 40

RX Note

JUNE 30, 2023

Similarly, in community pharmacy, you may come across patients seeking acute gout treatment. While it is common to prescribe both colchicine and NSAIDs for acute gout attacks, this combination can be unsafe for renal impaired patients. A patient being prescribed atorvastatin and simvastatin from two different clinics.

Dosage 40

Dosage Community Pharmacies Inpatient Diabetes 40

PharmaShots

APRIL 3, 2023

Meanwhile, Selecta and Sobi reported P-III trial (DISSOLVE I & II) results of SEL-212 for chronic refractory gout Starting with the latest acquisitions, Pfizer acquired Seagen for ~$43B. Shots: The first quarter of 2023 highlights major acquisitions in the pharma and biotech industry along with multiple approvals.

Biosimilars 40

Biosimilars Diabetes Compounding Hospitals 40

The Thyroid Pharmacist

JUNE 14, 2023

7] Muscle and Joint Pain : Hypothyroidism can lead to numerous symptoms such as joint pain , weakness, aches, stiffness, muscle cramps, and carpal tunnel, as well as a higher incidence of gout, likely caused by reduced kidney function. Cleveland Clinic. Fear and the Defense Cascade: Clinical Implications and Management.

Health and Personal Care Stores 104

Health and Personal Care Stores Immunity Immunization Documentation 104

pharmaphorum

NOVEMBER 27, 2020

Colchicine, a cheap and readily available anti-inflammatory drug used to treat diseases such as gout, is to be investigated as a potential therapy for COVID-19 in the UK’s ground-breaking RECOVERY trial. ” The post Cheap gout drug colchicine added to UK’s RECOVERY COVID-19 trial appeared first on.

Hospitals 104

Hospitals Dosage 104

The Thyroid Pharmacist

NOVEMBER 17, 2022

However, I’ve also seen similar clinical benefits with Wobenzym PS.). Here’s the summary of the study: Forty people with Hashimoto’s who were taking levothyroxine, were given systemic enzymes for three to six months. Thyroid antibodies. Inflammation. Alzheimers. Atherosclerosis. Food sensitivities. Behçet’s disease. Diabetic nephropathy.

Health and Personal Care Stores 98

Health and Personal Care Stores Immunity Immunization Compounding 98

RX Note

FEBRUARY 23, 2023

The information provided is meant to act as a guide and should not substitute professional clinical judgement. Ichthyosis Vulgaris - Fish scale disease Pain Pain - Optimizing pain management Migraine - Recurrent primary headache Gout - Big toe joint is most commonly affected. insulins, inhalers, GTN, transdermal patches, etc.)

HIV Treatment and Prevention Agents 75

HIV Treatment and Prevention Agents Community Pharmacies Labelling Chemotherapy 75

RX Note

FEBRUARY 9, 2024

Differential diagnosis 鉴别诊断 - The determination of which of two or more diseases with similar symptoms is the one from which the patient is suffering, by a systematic comparison and contrasting of the clinical findings. Gout 通风 - A type of arthritis that occurs when extra uric acid in the body forms crystals in the joints.

Immunity 40

Immunity Immunization Diabetes Communication 40