STAT

JANUARY 30, 2024

A pain relief drug developed by Vertex Pharmaceuticals succeeded in late-stage clinical trials, the company announced Tuesday, bringing the biopharma giant a step closer to launching what observers believe could be a potential blockbuster and upending decades of pharma failure in a complicated field.

Drug Development 331

Drug Development 331

STAT

JANUARY 2, 2024

Here is STAT’s biotech scorecard, our regular ledger of stock-moving biotech events, for the first quarter: In December, Vertex Pharmaceuticals announced results from a mid-stage clinical trial showing its experimental, non-opioid drug reduced pain in people with diabetes who have chronic pain.

Diabetes 276

Diabetes 276

STAT

APRIL 8, 2024

A fully independent clinical trial researchers thought might disprove a cardiac device made by Shockwave Medical, the company that Johnson & Johnson is buying for $13 billion, ended up providing some support for the device’s utility. but was previously rejected by the U.S.

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294

STAT

NOVEMBER 7, 2023

doctors scale back their use of  opioid painkillers , a new option for hard-to-treat pain is taking root: ketamine, the decades-old surgical drug that is now a  trendy psychedelic therapy. WASHINGTON (AP) — As U.S.

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STAT

AUGUST 18, 2023

Over the course of five months, women underwent egg retrievals without any pain medication. Although this procedure is typically done under heavy sedation, a nurse at the clinic had replaced fentanyl with saline. This is not the first time a health care worker has diverted pain medications away from patients.

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STAT

FEBRUARY 15, 2024

Are 11th-hour changes ominous for clinical trials? And what’s next in pain medicine? We also discuss the latest news in the life sciences, including a twist in the future of Alnylam Pharmaceuticals, competition to Vertex Pharmaceuticals’ pain drug, and Gilead Sciences’ latest acquisition.

Drug Pricing 254

Drug Pricing 254

STAT

APRIL 19, 2023

The Food and Drug Administration’s latest plan to study whether opioids are effective as a chronic pain treatment is facing significant resistance from addiction and pain care experts.

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262

ALiEM - Pharm Pearls

MARCH 5, 2024

For over 3500 years, willow bark has been used as a traditional medicine to treat fevers and pain [1]. Willow tree bark extract has been used as an herbal supplement for chronic lower back pain, joint pain, osteoarthritis, sports performance, and weight loss [3]. Tinnitus, nausea, vomiting, and abdominal pain are common.

Clinical Pharmacology 283

Clinical Pharmacology Adverse Reactions Compounding 283

ALiEM - Pharm Pearls

MARCH 18, 2024

She denied pain in the hand and has had no problems moving the finger. Patients usually present with pain, swelling, tingling, numbness, and ecchymosis. Painful Blue Finger-Achenbach’s Syndrome: Two Case Reports. View other cases from this Clinical Image Series on ALiEM. She denied trauma to the hand or finger.

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STAT

AUGUST 2, 2023

Vertex Pharmaceuticals has spent decades trying to develop molecules that reduce pain safely and potently, searching for success in a field its own executives have dubbed a graveyard for drug discovery. The drug, VX-548, blocks signals from pain-sensitive neurons before those electrical messages reach the brain.

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STAT

FEBRUARY 1, 2024

We explain the debate over Vertex Pharmaceuticals’ novel pain drug, whose success in clinical trials comes with a sizable caveat. We cover all that and more this week on “The Readout LOUD,” STAT’s biotech podcast.

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250

ALiEM - Pharm Pearls

OCTOBER 23, 2023

A 32-year-old man with a history of traumatic globe rupture from a stab wound two months ago, status post repair, presented to the emergency department for worsening right eye pain and green malodorous drainage for the past three days. He described the pain as severe, throbbing, constant, and non-radiating. x 10^3 /uL with 80.4%

Medical Schools 275

Medical Schools 275

ALiEM - Pharm Pearls

MARCH 1, 2024

A 24-year-old female with no pertinent PMHx presents to the ED with a chief complaint of eye pain. She reported a 10-day history of worsening right eye pain following being punched in that eye. She had been managing her pain with ice and had not taken any OTC medications. Minimal pain with EOM. No apparent distress.

Hospitals 150

Hospitals 150

pharmaphorum

MARCH 4, 2024

Inhaled cannabinoids have been shown to perform better than placebo in providing pain relief for people suffering from acute migraine in a clinical trial

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145

Outsourcing Pharma

APRIL 18, 2024

as a space where partners can come together to collaborate, innovate, and ideate on solutions to the biggest clinical supply chain pain points. Yesterday, Thermo Fisher Scientific opened its first Innovation Lab in Center Valley, Pennsylvania.,

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STAT

MARCH 17, 2023

The message went out to some patients and to all of the employees of his company’s clinics across nine states — what had, up until moments before, been one of the largest ketamine clinic chains in the country. To patients, the news came as a complete shock. To patients, the news came as a complete shock.

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Pharma Times

NOVEMBER 4, 2022

Funding will be used to broaden partnerships with the NHS and improve patient experience

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111

Outsourcing Pharma

SEPTEMBER 2, 2021

The decentralized trial tech firm will work with Applied VR on five studies testing the viability of virtual-reality therapy in treating pain patients.

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105

STAT

NOVEMBER 11, 2023

But frequently angioplasty is used mainly to relieve chest pain, or angina. In people who have just had a heart attack, this can be lifesaving.

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360

Outsourcing Pharma

MARCH 11, 2024

On March 7, Celadon Pharmaceuticals plc, a leading UK-based pharmaceutical company specializing in cannabis-based medicines, unveiled promising findings from an early economic analysis of its chronic pain clinical trial, dubbed CANPAIN.

Pharmaceutical Companies 124

Pharmaceutical Companies Pharmaceutical Companies 124

STAT

MARCH 7, 2023

But when a pain crisis struck — an agonizing emergency of sickle cell disease in which Gray’s misshapen red blood cells caught in her blood vessels — the visit became a days-long hospital stay. LONDON — Victoria Gray had come to Nashville, Tenn., She went home, thought and prayed on it.

Hospitals 246

Hospitals 246

STAT

NOVEMBER 16, 2023

Clinical trials have shown the one-time treatment enabled many sickle-cell patients to live free of debilitating pain crises and freed thalassemia patients from needing regular blood transfusions.   The authorization of the therapy, from Vertex Pharmaceuticals and CRISPR Therapeutics, is itself not a surprise.

Drug Development 364

Drug Development 364

ALiEM - Pharm Pearls

NOVEMBER 27, 2023

A 24-year-old G1P0010 female with a PMHx of ovarian cyst (unknown laterality) and emergency contraceptive use 3 months prior presented with sudden onset abdominal pain (upper > lower) that awoke her from sleep four hours prior to presentation with associated nausea and mild lower back pain. Appearing to be in acute pain.

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STAT

NOVEMBER 18, 2022

Biosplice’s bid to transform the treatment of everything from arthritis to cancer ran into a snag this week, with the San Diego biotech announcing that its experimental osteoarthritis drug failed to benefit patients in a pair of Phase 3 clinical trials.

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STAT

AUGUST 3, 2023

Launching your first clinical trial is the type of announcement most biotech executives eagerly anticipate, hoping to celebrate with employees. But for Celsius Therapeutics CEO Tariq Kassum, it’s proving to be more difficult than he anticipated. That’s because in recent days, Celsius, based in Cambridge, Mass.,

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226

Pharmaceutical Business Review

JANUARY 10, 2024

inhibitor, FZ008-145 is designed to provide non-addictive pain relief. target has been clinically validated in five acute pain and one chronic pain proof-of-concept studies. Existing medications demand improvements in efficacy and safety, addressing substantial unmet clinical needs.

Drug Development 95

Drug Development 95

STAT

SEPTEMBER 26, 2023

Ionis Pharmaceuticals, a California biotech that has spearheaded the development of RNA-targeting medicines, announced on Tuesday that its drug against familial chylomicronemia syndrome, a rare and serious disease that prevents the body from breaking down fats, succeeded in a late-stage clinical trial.

Drug Development 298

Drug Development 298

ALiEM - Pharm Pearls

MARCH 6, 2023

A 48-year-old female with a past medical history of opioid use disorder on suboxone presents with abdominal pain for one day. The patient developed sharp diffuse upper abdominal pain the evening prior to arrival that resolved. The pain recurred again today and was associated with bilious emesis.

Hospitals 189

Hospitals 189

STAT

JANUARY 24, 2023

Amid ongoing controversy over clinical trial transparency, a new analysis found that results of 43 studies involving thousands of children were never reported to a U.S. One study explored the use of a particular painkiller for reducing the amount of opioids needed to treat pain following heart surgery.

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STAT

OCTOBER 14, 2022

This time around, we note that Cognition Therapeutics hired Paul Tiseo as vice president of clinical development. Previously, he worked at Centrexion Therapeutics, where he was executive director of clinical development, and before, that he was clinical lead for pain therapeutics at Regeneron Pharmaceuticals.

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STAT

MARCH 18, 2023

In an intermediate-stage clinical study of 259 people with moderate-to-severe plaque psoriasis, the highest dose of the daily pill completely cleared itchy and painful patches of skin in one-third of the patients after 12 weeks.

Immunity 275

Immunity Immunization 275

STAT

APRIL 19, 2024

But many influencers and friends on social media play up all the pounds a person lost while playing down side effects that can be nasty, such as painful headaches and bouts of vomiting. Biocon is developing its own version of Novo Nordisk’s Wegovy and is prepared to conduct a clinical trial next year if needed , Reuters reports.

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ALiEM - Pharm Pearls

SEPTEMBER 11, 2023

A 29-year-old female with a past medical history of migraine headaches presented to the emergency department (ED) for several hours of bilateral eye pain, redness, and decreased visual acuity. She woke up the following day at 6:00 with severe, bilateral eye pain, blurry vision, and difficulty opening her eyes due to pain.

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150

European Pharmaceutical Review

SEPTEMBER 15, 2023

Dercum’s disease is characterised by painful lipomas developing primarily on the trunk in the body. As a primary endpoint, painful lipomas dimension in the high-dose group was reduced by 51.3 As a primary endpoint, painful lipomas dimension in the high-dose group was reduced by 51.3 percent and 54.7 percent and 54.7

Compounding 118

Compounding 118

European Pharmaceutical Review

JANUARY 11, 2024

chronic neuropathic pain is at present, mainly managed with antidepressants… antiepileptic drugs… as well as opioids” Neuropathic pain affects over 400 million people worldwide, according to Hoba Therapeutics. What are the key current challenges in the development of pain medicines?

Drug Development 81

Drug Development Medical Schools 81

ALiEM - Pharm Pearls

NOVEMBER 13, 2023

A 57-year-old female college counselor living in the northeastern United States with no PMH presented for evaluation of rash, joint pain, and dyspnea for the past three weeks. The patient has pain in her hands and when moving her fingers. The patient has pain in her hands and when moving her fingers.

Inpatient 197

Inpatient 197

ALiEM - Pharm Pearls

DECEMBER 8, 2023

A 45-year-old male status-post right nephrectomy secondary to a renal mass presented to the emergency department with right-sided flank pain. He endorsed low-grade intermittent right-sided flank pain since the nephrectomy one year prior, associated with an increasingly enlarging mass extending laterally from his right abdomen.

Diabetes 150

Diabetes 150