Thu.May 23, 2024

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New data show the HPV vaccine prevents cancer in men, too. Why don’t more people get it?

STAT

You’d think if there were a vaccine that would prevent tens of thousands of cases of cancer a year, people would want it for themselves and for their kids. But new data being released Thursday ahead of the annual meeting of the American Society of Clinical Oncology show that just isn’t the case.

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AstraZeneca’s $80B sales goal by 2030 reflects industry’s penchant for long-term bets

PharmaVoice

Promises made by pharma and biotech companies show confidence in the future of their business and dedication to financial success, R&D and environmental protection.

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Reversing progress, stroke rates are rising, especially in working-age adults

STAT

Stroke prevalence has been climbing over the past decade, reversing a steady decline among all Americans while rising the most among adults under 65, a new CDC analysis reports. Strokes still strike more adults older than 65, but the increase at younger ages mirrors another recent turnaround: rates of heart failure deaths, which had been dipping, are rising the most in adults under 45.

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Researchers combine herpes virus with cancer vaccine to treat brain cancer in children

Pharma Times

High-grade gliomas are rare, malignant tumours which account for up to 12% of all childhood brain tumours

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Opinion: Addressing health care workers’ trauma can help fight burnout

STAT

Burnout is a growing crisis in health care: More than 50% of health care professionals report symptoms of it. Addressing the trauma they face at work can help. Halting burnout straddles the tension between addressing the individual factors versus the organizational factors behind it. It was once believed that burnout was related to health workers’ inability to cope with the natural stresses of their job.

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Orna, a circular RNA specialist, acquires a buzzy startup

BioPharma Dive

After laying off staff late last year, Orna is expanding through the purchase of ReNAgade Therapeutics, which was built around technology designed to more effectively deliver RNA-based medicines.

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ASCO24: An early look at cancer drug study results

BioPharma Dive

Clinical trial abstracts posted by ASCO Thursday give a peek at anticipated datasets from Immunocore, Merck & Co., J&J and Arcus Biosciences.

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Opinion: Making the case for fair compensation in clinical trials

STAT

I’ve been on three sides of the health care equation: I’ve beaten stage 4 colorectal cancer, I’m the mother of a son with an ultra-rare genetic abnormality, and I now work as the chief patient officer for Parexel, one of the world’s largest clinical research organizations. Having seen what people go through as they navigate the health care system and try to participate in clinical trials, I know that the road to participation must be smoother and easier — and n

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Cytokinetics eyes go-it-alone strategy for aficamten

pharmaphorum

Cytokinetics has been a top biotech takeover candidate for some time, thanks to blockbuster speculation about its lead drug aficamten, but a $1 billion-plus set of financing deals shows it is prepared to go to market on its own.

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In light of H5N1 outbreak, U.S. in talks with mRNA vaccine makers on bird flu

STAT

Want to stay on top of the science and politics driving biotech today?  Sign up  to get our biotech newsletter in your inbox. Good morning. Wall Street had a big reaction to H5N1 bird flu news yesterday. Was it warranted? We’ll discuss that today.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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Certain menopausal hormone therapy could raise ovarian cancer risk, study finds

BioPharma Dive

The findings, from two trials involving tens of thousands of women, could influence guidelines around the use of hormonal treatment for menopausal symptoms.

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STAT+: Cytokinetics CEO Robert Blum is on my Worst CEO shortlist again, and other thoughts

STAT

Thoughts about Cytokinetics after Wednesday night’s financing announcement : 1. Management is raising $500 million at $51 per share, when the stock was at $45 per share before the aficamtem study readout in December. That’s shocking. Somehow, management has not only removed all the M&A premium from the stock, but much or most of aficamtem’s value, too. 2.

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Collaboration is key to tackling geographical boundaries in CGT development

pharmaphorum

Collaboration is the key to unlocking the potential of cell and gene therapies (CGTs) across geographical boundaries. Explore how autologous treatments are shaping the future of this cutting-edge medical field.

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STAT+: Ahead of ASCO, J&J reports mixed data on next-generation radiopharmaceutical

STAT

An early-stage clinical trial of a radiopharmaceutical drug developed by Johnson & Johnson showed some signs of efficacy in prostate cancer patients, newly released data show, but four participants in the trial died. The drug, JNJ-6420, is designed to treat metastatic castration-resistant prostate cancer by delivering radioactive isotopes directly to cancer cells.

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Second fire at Novo Nordisk in a week now under control

pharmaphorum

Novo Nordisk’s second facility fire in a week is under control, although the office in Bagsvaerd affected by the latest blaze isn’t expected to be salvageable.

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STAT+: Biotechs turn to gene silencing for obesity drugs that can last longer than Wegovy

STAT

Enticed by the immense market opened by GLP-1 weight loss drugs Wegovy and Zepbound, a handful of biotech companies are trying to develop next-generation, longer-lasting therapies based on a very different approach: RNA interference. This Nobel Prize-winning science works by degrading the biological blueprints that RNA use to make proteins — without the genetic instructions, the troublesome proteins are never made and the gene is essentially muted.

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Merck builds in cell, gene therapies with Mirus Bio deal

pharmaphorum

Merck KGaA has agreed to a $600m deal to buy Mirus Bio, a specialist in transfection reagents used in the production of cell and gene therapies.

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STAT+: Pharmalittle: We’re watching a Cytokinetics deal with Royalty Pharma, Cue Health shutting down, and more

STAT

Top of the morning to you. I’m filling in for Ed Silverman this morning, which means you’re getting Brooklyn instead of the Pharmalot compound, Barry’s tea instead of flavored coffee, and most shockingly, adorable cats. I know. But I can still line up some listening material for the morning news. I know, we are all eagerly awaiting the return of our beloved Pharmalot, but let’s get to it.

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Biogen Agrees to Acquire HI-BIO for $1.15 Billion

Pharmaceutical Commerce

The deal features felzartamab, an investigational anti-CD38 monoclonal antibody, whose clinical outcomes have shown potential to tackle various immune-mediated diseases.

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STAT+: Setting the table: What to expect at this year’s ASCO meeting

STAT

This is the online edition of Adam’s Biotech Scorecard, a subscriber-only newsletter. STAT+ subscribers can sign up here  to get it delivered every Thursday to their inbox. I have one more, admittedly braggy thing to say about last week’s STAT Breakthrough Summit West in San Francisco. Of course we curated an incredible roster of influential industry leaders to speak on stage.

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Biogen bets $1.15bn on immunology drug developer HI-Bio

pharmaphorum

Biogen has expanded its specialty immunology pipeline with an agreement to buy Human Immunology Biosciences (HI-Bio) and its lead drug felzartamab, in trials for a range of diseases including IgA nephropathy (IgAN).

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Listen: More tumult at BIO & coercive care for sickle cell patients

STAT

How does a drug industry lobbying group move forward after years of upheaval, including having four CEOs in four years? This week on “The Readout LOUD,” STAT’s Chief Washington Correspondent Rachel Cohrs Zhang joins us to discuss the layoffs at trade group BIO and how things may be changing at the trade group. We also invite STAT reporter Eric Boodman on to talk about his new investigative series of stories exploring how Black women with sickle cell disease were coerced into

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Which companies will last? Success begins with the basics

pharmaphorum

In the post-COVID world, which start-ups will thrive and which will fizzle? Discover the fundamental strategies that separate the winners from the losers.

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Louisiana legislature approves bill classifying abortion pills as controlled dangerous substances

STAT

BATON ROUGE — Two abortion-inducing drugs could soon be reclassified as controlled and dangerous substances in Louisiana under a first-of-its-kind bill that received final legislative passage Thursday and is expected to be signed into law by the governor. Supporters of the reclassification of mifepristone and misoprostol, commonly known as “abortion pills,” say it would protect expectant mothers from coerced abortions.

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NHSE urged to provide full list of available DPPs

The Pharmacist

NHS England must provide a full list of organisations with available designated prescribing practitioners (DPPs) before placement information is released to students, the Company Chemists’ Association (CCA) has urged. The association warned that without such a list outlining where to source DPPs, community pharmacy businesses could be ‘forced to offer fewer foundation placements than they […] The post NHSE urged to provide full list of available DPPs appeared first on The Pharmacist.

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Small Changes, Big Results: Incorporating Retrieval for Retention into Your Teaching

Pulses

By: Morgan Crawford, PharmD/MS Candidate 2024 and David E. Matthews, PharmD, BCACP On New Year’s Eve, did you make a “New Year’s resolution?” If so, have you managed to keep it? While most resolutions fail , successful ones often involve small, sustainable improvements. Consider this common resolution: to exercise regularly and build strength. A successful individual would not visit the gym for 8 hours daily for the first week of January and then claim to have accomplished their resolution for

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Chinese firm throws lifeline to Pfizer UK plant workers

pharmaphorum

China’s Asymchem Laboratories has agreed to take over the operation of a Pfizer manufacturing facility in Sandwich, UK, saving dozens of jobs.

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Progressing catheter insertion: A breakthrough in ultrasound guidance technology

Outsourcing Pharma

Continuing the Montreal startup ideas presented to OSP and others during a recent trip, this was another idea to come from Centech, the non-profit organization helping people develop their ideas in a bid to making them a reality.

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AstraZeneca and Nona Biosciences sign agreement for monoclonal antibody

Pharmaceutical Technology

AstraZeneca has entered into a worldwide licence and option agreement with Nona Biosciences for a preclinical monoclonal antibody.

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What can pharma companies do to get promising antimicrobials to the frontlines of drug resistance?

Outsourcing Pharma

A new report from Access to Medicine Foundation gives the advice to ensure the few promising antimicrobials in development reach patients on the frontlines of drug resistance.

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UK MRC and AstraZeneca partner for translational clinical research

Pharma Times

The partnership will provide six MRC clinical fellows with industry placement opportunities

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Pharma companies urged to act on antimicrobials to combat drug resistance

Express Pharma

A new report from the Access to Medicine Foundation calls for urgent changes in research and development (R&D) to ensure new antibiotics and antifungals reach patients facing drug-resistant infections. The report examines five late-stage antimicrobial projects targeting severe drug-resistant pathogens, revealing that structured advance planning for access and stewardship is not yet standard among companies.

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Merck’s MilliporeSigma agrees to acquire Mirus Bio for $600m

Pharmaceutical Technology

Merck KGaA’s MilliporeSigma has entered a definitive agreement for the acquisition of Mirus Bio in a deal totaling $600m (€500m).

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Asymchem Takes Ownership of Former Pfizer Manufacturing Facilities

Pharmaceutical Commerce

The CDMO will run the active pharmaceutical ingredient pilot plant in Sandwich, UK, along with development laboratories.

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Development of novel water-soluble inks for 3D-printed polypills

European Pharmaceutical Review

A paper has reported a multi-material ink-jet 3D printing (MM-IJ3DP)-based method that could enable tailored drug release profiles of personalised pharmaceutical tablets during manufacturing. While biocompatible water-soluble polymers as excipients, have “been recently explored to produce gels [they have not been investigated] as a water-soluble excipient”, according to the paper.

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