April, 2023

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Tired of ‘dead end’ approach, herpes patients mobilize to demand government action

STAT

A medical student spoke emotionally about grappling with a diagnosis his classes told him little about. A young queer man took one test, got a different result on the next, and is now saving up the money needed for the most advanced diagnostics, which insurers rarely cover. A young woman tested positive, got little guidance from her doctor and found information on government sites that she interpreted as pushing abstinence.

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Trick of the Trade: Gel-free ultrasound-guided peripheral IV technique

ALiEM - Pharm Pearls

Ever finally step away from a busy resuscitation and someone stops you for peripheral IV access? You set up everything, have the patient positioned, and then notice there is no sterile ultrasound gel. No gel? No problem. The trick is to eliminate anything of poor acoustic impedance between the ultrasound probe and the patient’s skin. Trick of the Trade 1.

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Roy Vagelos is retiring and leaving a legacy of leadership lessons

PharmaVoice

The longtime pharma leader is stepping down from his role as chair of Regeneron’s board in June after decades in drug development.

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FDA approves new ALS medicine in precedent-setting decision

BioPharma Dive

Biogen’s drug failed the key study meant to show it can slow the nerve-destroying disease, but the drug’s effect on a protein of interest led the FDA to conditionally clear it for market.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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IBCC – ABG, VBG, and pulse oximetry

EMCrit Project

The precise utilization of ABG, VBG, and pulse oximetry remains controversial. Unfortunately, there is little high-level evidence investigating whether these interventions affect patient outcomes (for example, there is precious little evidence to support most of the target values that we're chasing after). This chapter attempts to explore the strengths, weaknesses, and indications for various techniques. […] EMCrit Project by Josh Farkas.

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Advice For New Pharmacists: Lessons Form The Front Lines

ID Stewardship

In this article advice for new pharmacists is provided by a pharmacist with 15 years of experience and answers are sourced from commentary on Twitter as well. Composed By: Timothy P. Gauthier, Pharm.D., BCPS, BCIDP Article Posted 1 May 2023 Recently while attending the American Pharmacist Association’s annual meeting in Phoenix, AZ I walked by a grown man at a breakfast bar wearing a head-to-toe onesie patterned with Dunkin’ Doughnuts (DD) logos.

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‘We are working in an environment that is setting us up to fail’

The Pharmacist

If you go into a community pharmacy, it’s not hard to see the staff being pulled in different directions. Patients are waiting; prescriptions are piling up; delivery drivers need to head out. It’s no easier in other sectors of pharmacy, where most of us are dealing with limited support staff and an increasingly high workload. […] The post ‘We are working in an environment that is setting us up to fail’ appeared first on The Pharmacist.

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A physician’s perspective on health equity, diversity and inclusion

PharmaVoice

Dr. Preeti Parikh sees parallels between promoting health equity and current DE&I challenges in the workplace.

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5 FDA decisions to watch in the second quarter

BioPharma Dive

By the end of June, the agency could clear a gene therapy for Duchenne muscular dystrophy and two vaccines for RSV, as well as issue a precedent-setting decision on a closely watched ALS drug.

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Biocon Academy conducts graduation ceremony for 185 students across four programs

Express Pharma

Biocon Academy, a Centre of Excellence for Advanced Learning in Applied Biosciences and a CSR initiative of Biocon held its seventh Graduation Day at its Bengaluru Campus, with 185 students graduating this year. Eight batches across four programs of Biocon Academy namely Biocon KGI Certificate Program in Biosciences, Biocon JSS AHER Certificate Program in Global Regulatory Affairs, Biocon Ramaiah Certificate Program in Quality Control Analytical, and BITS Biocon Certificate Program in Applied In

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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PulmCrit wee- When guidelines disagree: neuroprognostication post cardiac arrest

EMCrit Project

Recently, two sets of guidelines for neuroprognostication following cardiac arrest were released – almost simultaneously. In a perfect world, two evidence-based guidelines based on the same evidence would be the same. But of course, this isn't actually the case. The guidelines differ significantly. The Neurocritical Care Society guidelines recommended this general approach:(36949360) Meanwhile, the Canadian […] EMCrit Project by Josh Farkas.

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In counties with more Black doctors, Black people live longer, ‘astonishing’ study finds

STAT

Black people in counties with more Black primary care physicians live longer, according to a new national analysis that provides the strongest evidence yet that increasing the diversity of the medical workforce may be key to ending deeply entrenched racial health disparities. The study , published Friday in JAMA Network Open, is the first to link a higher prevalence of Black doctors to longer life expectancy and lower mortality in Black populations.

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Clinical in pharmacy: In airport pharmacy the day can start early at 4am!

The Pharmacist

Hala Jawad is a community pharmacist based at Boots, London Gatwick Airport. She talks about the opportunities and challenges in helping the patients visiting an airport pharmacy. How long have you been working in community pharmacy? What attracted you to working in community? I have worked in community pharmacy for around nine years, and I […] The post Clinical in pharmacy: In airport pharmacy the day can start early at 4am!

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5 minutes with — DTRA’s Dr. Amir Kalali

PharmaVoice

An industry veteran, innovator and curator, Dr. Amir Kalali’s vision for the future is patient-focused.

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Gene therapy startup Vedere to close two years after launch

BioPharma Dive

The startup, a successor to an eye gene therapy biotech that Novartis bought in 2020, will wind down after preclinical experiments didn’t meet the bar set by its leaders.

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Eli Lilly Invests Heavily in Debut Mounjaro TV Ad Campaign for Diabetes

PharmExec

Eli Lilly debuts its first Mounjaro TV commercial amid high demand for the diabetes injection, which also shows promise in weight loss applications and outperformed rivals Ozempic and Wegovy in clinical trials.

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FDA declines Eli Lilly’s bowel disease drug over manufacturing issues

Pharmafile

Pharma giant Eli Lilly’s Biologic Licence Application (BLA) for its bowel disease drug has been declined by the FDA over concerns about the proposed manufacturing of the drug. However, concerns weren’t expressed over the clinical data package, safety or label for the medicine. Mirikizumab was hoped to become a new drug treatment for ulcerative colitis (UC), a condition where abnormal reactions in the immune system cause inflammation in the inner lining of the colon.

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Demand for home health aides is soaring. So why are they still so undervalued?

STAT

On most days around 2pm, home health aide Duane Crichlow can be found in an apartment in Sunset Park, Brooklyn, playing catch with his client — a man in his 30s with a developmental disability who is quick to give Crichlow hugs and kisses. If it’s nice outside, Crichlow will walk his client, who is nonverbal and in a wheelchair half the time, down three flights of stairs, hauling the wheelchair back and forth separately.

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IOL Chemicals and Pharmaceuticals appoints Vikas Vij as CEO

Express Pharma

IOL Chemicals and Pharmaceuticals has appointed Vikas Vij as the new Chief Executive Officer, with effect from 3rd April 2023. He takes over from Dr Sanjay Chaturvedi. Vij’s role is expected to aid the company to bolster growth across domestic and international markets by leading IOL’s portfolio enhancement and efficiencies. Vij has a techno-commercial background with a nuanced understanding of Active Pharmaceutical Ingredients (API), Finished Dosage Forms (FDF), Custom Pharmaceutical Services (

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The 99 seconds that changed this CEO’s life

PharmaVoice

Peter Kirk’s marathon story of inspiration and perseverance.

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Merck to buy inflammatory disease drugmaker Prometheus for $10.8B

BioPharma Dive

The pharma has struck the sector’s second-largest buyout this year, announcing a deal for the developer of an inflammatory bowel disease treatment that’s shown promise in testing.

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PulmCrit Blogitorial – Why we will never know how to manage stress hyperglycemia

EMCrit Project

(Blogitorials are short, informal blogs that are written in the spirit of a tweetorial). Stress hyperglycemia is an everyday occurence in the ICU, but we hardly know how to treat it. I've been waiting years for this topic to be clarified… but I've realized that such clarity will probably never be reached. Why? The traditional […] EMCrit Project by Josh Farkas.

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Psychedelic medicines: are they gaining traction in Europe?

European Pharmaceutical Review

Psychedelics are a class of psychoactive substances that produce temporary changes in perception, mood and cognitive processes. 1 Some psychedelics are found in nature, including psilocybin, a naturally occurring molecule found in almost 150 species of mushrooms which turns into psilocin once ingested, causing psychedelic effects. Other psychedelics are man-made, such as lysergic diethylamide (LSD), which was first synthesised in 1938 by Albert Hofmann at a laboratory in Switzerland. 2 LSD is wi

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Hospitals pledge to protect patient privacy. Almost all their websites leak visitor data like a sieve

STAT

Every hospital in America promises to protect the privacy of its patients and the details of their medical care. And almost every one of them uses sophisticated data tools to track and share the personal information of visitors as soon as they start clicking on their websites. A new study found that 99% of U.S. hospitals employed online data trackers in 2021 that transmitted visitors’ information to a broad network of outside parties, including major technology companies, data brokers, an

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Breathing easy: How digital inhalers are changing asthma treatment

Pharmaceutical Technology

AstraZeneca , Teva Pharmaceuticals , and Novartis , and other companies, are expanding their reach in the asthma space by capitalizing on digital technologies to enhance the patient experience. But experts say the complete integration of these devices and platforms into the healthcare system remains to be seen. Dr. Amy Chan, senior clinical research fellow at the School of Pharmacy, University of Auckland, says digital inhalers have existed for almost 30 years.

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Study finds air pollution lowers Covid vaccine response

Express Pharma

People exposed to higher levels of air pollution before the pandemic had lower antibody responses to COVID-19 vaccines, according to a study. In particular, exposure to fine particulate matter (PM2.5), nitrogen dioxide (NO2) and black carbon was associated with about a 10 per cent decrease in IgM and IgG antibody responses in people without prior infection, the researchers said.

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Novo boosts sales outlook on strong demand for obesity drug

BioPharma Dive

The Danish drugmaker nearly doubled the 2023 forecasts for Wegovy and Ozempic in the latest indicator of the sales potential of an emerging and competitive class of weight loss drugs.

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Letter 4: The Heart of a Manager

The Honest Apothecary

My Dear Nephew Simon, So great to hear from you again. I’m glad that you found some of the practical advice in the last letter to be helpful. Don’t be too discouraged by the negative cultures being created by other managers in different departments. Focus on your team for now. In time we will talk about how you expand your influence with other stakeholders around the organization.

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A review of MALDI-TOF for microbiological identification

European Pharmaceutical Review

The high reliability of matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry (MS) systems for microbiological identification offer an alternative to serological-based methods, according to a review by researchers. “New technologies for the accurate and rapid identification of bacteria are essential in various fields of applied microbiology.

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Opinion: Why involuntary treatment for addiction is a dangerous idea

STAT

As the overdose crisis rages on and the pandemic-fatigued public runs low on empathy, there have been increasing calls for expanded involuntary commitment for people with substance use disorder. Some of the advocacy for more coercive treatment seems rooted in a disdain for people who use drugs, most especially when their drug use occurs visibly and in close geographic proximity to affluence, for example in San Francisco or in the Massachusetts Avenue and Melnea Cass area of Boston which borders

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Ghana becomes first country to approve Oxford’s malaria vaccine

Pharmaceutical Technology

Ghana’s Food and Drug Authority (FDA) has approved R21/Matrix-M malaria vaccine in children aged 5 to 36 months, marking the first regulatory clearance for the University of Oxford-developed vaccine in any country in the world. Serum Institute of India (SIIPL), manufacturer and licence holder of the vaccine, has been notified of the registration by Ghana’s FDA.

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Episode 813: Can you give lactated ringer’s solution to a patient with elevated lactate?

Pharmacy Joe

In this episode, I’ll discuss giving lactated ringer’s solution to a patient with elevated lactate. Episode 813: Can you give lactated ringer’s solution to a patient with elevated lactate? Subscribe on iTunes , Android , or Stitcher Lactated ringers is considered a suitable fluid for resuscitation in sepsis. In fact, it is becoming more common to use it as a resuscitation fluid as it contains a more physiologic level of chloride than normal saline and is not expected to cause hyperchlorem

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Seagen, Astellas win expanded FDA approval for bladder cancer drug

BioPharma Dive

The first-line approval of Padcev together with Keytruda is viewed as important to expanding the drug’s market, and comes weeks after Pfizer agreed to buy Seagen for $43 billion.

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Discussing Sterile Aseptic Connectors with Todd Andrews (INTERPHEX 2023)

PharmaTech

Todd Andrews, global director of Applications and Business Development at CPC, discusses sterile aseptic connectors, flexibility in manufacturing, and more in an interview held at INTERPHEX 2023.

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FDA approves allogeneic stem cell transplant therapy

European Pharmaceutical Review

“The approval of Omisirge is a significant development in hematopoietic stem cell transplantation” Omisirge ® (omidubicel-onlv), now US Food and Drug Administration (FDA) approved , is the first allogeneic stem cell transplant therapy to be given marketing authorisation based on results from a global, randomised Phase III clinical study. The treatment is indicated for patients 12 years and older with hematologic malignancies planned for umbilical cord blood transplantation, following myeloablati

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