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Roche nabs breakthrough tag for TIGIT cancer immunotherapy

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Meanwhile, drugs targeting TIM-3, LAG3, VISTA and STING also coming through development. The post Roche nabs breakthrough tag for TIGIT cancer immunotherapy appeared first on.

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After a slow start for expensive CAR-T therapies, drug developers revisit oral therapies for blood cancer

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There’s been huge progress in treatments for blood cancer in recent years – but drawbacks of expensive CAR-T cell and injected antibody therapies have led drug developers to look at novel oral therapies as patient-friendly alternatives.

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Cannabinoids receptors: popular preclinical target but banned in 137 countries

Pharmaceutical Technology

Collectively, cannabinoid receptors (CB1 and CB2) are currently the most popular targets in preclinical stage of development, with 391 drugs tagged in total. The most popular indication for cannabinoid receptor drugs is neuropathic and general pain, which accounts for approximately 27% of the drug pipeline.

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Almirall and IRB Barcelona team up to tackle skin disease

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The hope is that they will harness and re-programme natural cellular mechanisms to selectively remove the disease driving proteins from human tissues, working by boosting interactions – gluing – between therapeutically relevant proteins and the machinery used by cells to naturally tag and destroy proteins.

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Rare Disease Spotlight – tracing the rise of orphan drug designations over almost 40 years

Pharmaceutical Technology

Almost 40 years since it was instituted, some have described the FDA’s orphan drug program, which is meant to foster innovation, as “ one of the most successful US legislative actions in recent history ”. Others judge its success based on the fact that 95% of rare diseases still have no available therapies and patient needs remain unmet.

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Advanced therapies and the high-profile pricing dilemma

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The advancements made in drug development over the last decade have seen the arrival of a number of treatments that offer one-time cures and more effective therapies for conditions in smaller patient populations. However, with a price tag of €1.58 How to navigate the new climate. At more than $2.1

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Orphan drugs’ financial success raises questions

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And of course, in many cases, these drugs have higher than average price tags compared to the wider market which is due to the limited – or in most cases – non-existent competition within a treatment area.”. Raising questions.